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protein-coupled receptors (GPCRs) may be a good option to try to prolong our life while maintaining good health since

Moreover, since pharmacological tools to study PKC isozymes generally lack specificity and/or potency

Sponsors This event would not be possible without the generous support of our sponsors: NIS Proteos Since

Since studies have indicated that flavonoids can target brain GPCRs and provide neuroprotection via inhibition

However, controversy remains regarding its role in breast cancer since both pro- and anti-metastatic

interactions between the negative sulfate groups in the N-terminus and the positively charged chemokines (Ludeman removal are ruled out it is possible that indirect effects may also contribute to the observed phenotype since

This interest has been driving efforts to understand their pharmacology since the 1980s.

drugs, however they often have serious side effects and too low or temporary therapeutic effects.[3,4] Since Since BBVs lack downstream signaling, doing a quantitative lice-cell assay using the same ligand would G.; Puri, V.; Singh, R. D.; Hanada, K.; Pagano, R. E.; Miller, L. J.

Reference Roy, S., Sinha, S., Silas, A. J., Ghassemian, M., Kufareva, I., & Ghosh, P. (2024).

As part of these updates, a pricing adjustment is planned for 2026 — the first since Premium launched

Most of them are small molecules capable of going through the BBB , and since their targets are on the

One wrong assumption about how your molecule behaves in a living system can sink months of work and millions

Since you are reading this newsletter, you only have to click on the event page to join us.

Since MOR receptor regulates pain perception and reward, the dysfunction in the MOR-SNARE complex interaction

GPCR dimers are very attractive molecular entities since they have been found to drive biased signalling

Signaling bias can be seen as complex as advantageous since selectively inhibiting certain signaling

However, opioids that prevent recruiting β-arrestin 2 do not address the problem since ligands that only

In research, including the GPCR world collaboration isn’t a luxury. It’s survival.

The Quick Glance: pA₂ as Shortcut Sometimes, discovery projects don’t have the luxury of full curve analyses

This wasn’t luck. It was designed. “There was a bit of luck,” she admits. But luck alone doesn’t sustain an ecosystem. What mattered was how leadership leveraged luck into durable structure  — through funding strategies, It’s a competitive advantage. 🎧 Listen to the full episode:   Leadership, Luck, and GPCR Signaling 🔓

Leadership, Luck, and the Lab The episode isn’t just about technology — it’s also about how careers are

Luck, Leadership & GPCR Signaling Michelle is clear: luck played a role. But so did choice. It’s easy to call it luck. But luck only works if you say yes when the door opens.

Pipeline efficiency isn’t luck—it’s literacy.

It wasn’t luck. It was persistence.

challenges Decades of insight distilled  into frameworks you can apply immediately Pipeline efficiency isn’t luck—it

Luc Van Hijfte and Dr. Wendy Young.

This is Lucía from the Celtarys Research chemistry team. 

a structural perspective, the -4 position of αH5 was key for the selectivity of G-protein coupling, since

“The first time I wore my lucky cactus shirt to a major meeting... and it led to a game-changing collaboration

The Tools to Detect Them Using the multiplexed GPCR library and Luminex assay , researchers can now: