Search Results

I Date & Time Thursday, November 2nd / 1:45 PM - 2:45 PM Title: Virion Display to Discover a Novel Ligand My project is investigating a new protein ligand for a GPCR and its potential role in obesity. GPCR Title: Characterization of Novel Opioid-Neurotensin Bifunctional Ligands Designed to Target Pain his graduate studies, Emile is interested in characterizing novel G protein-coupled receptors (GPCRs) ligands

The result: a framework for designing ligands with altered receptor preferences. ♦️ Defines “public” viral chemokine engineering demo This is a must-read for GPCR modelers, immunopharmacologists, and ligand

Lefkowitz, where his research focused on biased agonism, with the development of approaches to quantify ligand bias and the identification of ACKR3 as an endogenously beta-arrestin-biased receptor. His group and others have shown that many of these ligands act as biased agonists for the same receptor

He is one of the coordinators of recommendations to describe ligand bias towards signaling probes and His group recently developed an online resource of biased ligands and pathway effects to advance the

Michelle Halls unpacks how GPCR signaling isn’t just about ligand–receptor interaction. Michelle Halls unpacks how GPCR signaling isn’t just about ligand–receptor interaction.

His team develops fluorescence-based and chemically engineered tools to study gpcr internalization and ligand engagement in intact islets and neuronal circuits — insights that inform next-generation functional assay development and translational therapeutic design. in metabolic tissues What collaborative chemistry enabled in designing receptor-targeted fluorescent ligands His group develops imaging and chemical biology tools to reveal how GLP-1 and GIP receptors operate within

For decades, molecular modeling focused on explaining — rationalizing why a ligand binds, why a mutation A good model doesn’t just match published structures; it forecasts new biology, new ligands, and new

Different ligands stabilize distinct receptor states, leading to diverse signaling outcomes. Kinetics to Candidate Design Lecture 4: Unconventional GPCR Ligands as Drugs Lecture 5: Unique Exploitable GPCR-Ligand Behaviors for Therapeutic Benefit Terry Kenakin 🔒 Premium Content Watch recording Principles Aside from his vast experience in drug development, not to mention his extensive publication record, Summit A global gathering of researchers and professionals showcasing the latest developments in GPCR

Their lab doesn’t just simulate receptor-ligand interactions after the fact; they aim to forecast receptor By integrating molecular docking, molecular dynamics, and machine learning, they design ligands with affinity experiments are interpreted—and how those interpretations quietly shape SAR, lead selection, and development Experiments: How to Avoid the Most Common Data Pitfalls Binding affinity appears straightforward: add ligand

Mihaylov Intricacies Of Complex Assembly And Ligand Interaction In The Adhesion GPCR Latrophilin/Cirl Sampedro-Castaneda, Marisol1, Claxton, Suzanne1, Skehel, Mark2, Ultanir, Sila K.1 1Kinases and Brain Development Mihaylov " I am a postdoctoral researcher in the kinases and brain development laboratory led by Dr Sila moved to King's College London, where my interest and passion for kinases in brain health and disease developed I have recently also developed a strong interest in adhesion GPCRs and in particular, Bai1. " Simeon

exploring the effect of subcellular location on the signaling profile of CXCR3’s three endogenous biased ligands receptor phosphorylation in the differential signaling outputs of biased agonists, and demonstrating the ligand

Why This Matters Computational models are moving beyond interpretation into real-world prediction of ligand-receptor should predict , not just explain How his team uses structure-based modeling to identify novel GPCR ligands His team focuses on understanding how ligands modulate receptor function and how those insights can drive Outside academia, he advises companies through a consulting arm focused on ligand design strategy.

When the pharmacological properties of these new ligands are deemed exceptional, a lead optimization is realized and its therapeutic development initiates through a dedicated start-up."

Brigitte Kieffer , where she studied ligand-directed signaling at the delta-opioid receptor. Amynah studied how arrestins regulate ligand-directed signaling at delta-opioid receptors, and it is

These ligands stimulate receptor β-arrestin recruitment without activating canonical G protein signaling Critically, these ligands reduce addiction-associated behaviors in animal models without the side effects understand how the principles of receptor allosterism and functional selectivity can be leveraged in the development

completed his postdoctoral training at MIT and Harvard Med School in the lab of Hidde Ploegh , where he developed University of Wisconsin-Madison in the lab of Sam Gellman on the study of analogs of the GPCR peptide ligand Work in his independent laboratory is focused on developing new pharmacological tools via chemistry and

Angiotensin and Urotensin receptors through various biochemical approaches centered in the elucidation of ligand After a relocation to Stanford University where he pioneered work on ligand discovery for then orphan events in biasing latrophilins’ regulation of cyclic AMP pathways and for determining the magnitude of ligand

held a postdoctoral position at Forschungszentrum Jülich (Germany), where he worked on calculating ligand This was followed by a postdoctoral role at the Polytechnic University of Turin (Italy), where he developed Now in a tenure-track position, his research spans the development of computational methods such as structure-based

High throughput GPCR screening technologies enable deciphering host-microbiome communication and the development 12:20:00 GMT+0000 (Coordinated Universal Time) Details Exploration of GPCR signaling using nanobody-ligand CXCR3 Chloe Hicks Wed Oct 12 2022 17:20:00 GMT+0000 (Coordinated Universal Time) Details Isolating ligand Serrano-Marín Wed Oct 12 2022 18:50:00 GMT+0000 (Coordinated Universal Time) Details Oxytocin-Vasopressin Ligand-Receptor Duchamp Thu Oct 13 2022 17:00:00 GMT+0000 (Coordinated Universal Time) Details New GPCRdb structure and ligand

That’s why Celtarys designs custom fluorescent probes for every target, built for real pharmacology, That’s why Celtarys designs custom fluorescent probes for every target, built for real pharmacology, affinity experiments are interpreted—and how those interpretations quietly shape SAR, lead selection, and development Experiments: How to Avoid the Most Common Data Pitfalls Binding affinity appears straightforward: add ligand

screening, and identification of small molecule regulators of these proteins, and progressing such ligands in drug development programs. non-alcoholic steatohepatitis (NASH) and inflammatory diseases and Keltic Pharma Therapeutics (2020) which is developing

He is Chief Scientific Officer and co-founder of InterAx Biotech, where he specializes in the development Gebhard Schertler, he developed methods for kinetic mathematical analysis of GPCR signaling. Before focusing on the development of innovative mathematical modeling and simulation methods for drug the evolution of the company, which started with the development of technologies combining mathematical of interdisciplinary teamwork in drug and technology development, noting the challenges of communication

Her research centers on developing nanobody-ligand conjugates to target GPCRs, with a focus on receptors

. - Arthur will work on designing ligands for specific receptors, aiming to create biased agonists for The conversation ended with Arthur's ongoing research and his development of a new operational model. Allosteric Modulation and Hybrid Molecules Arthur and Yamina discussed the development of an operational also discussed the potential of certain drugs, like flumazenil, as 'nails' or compounds that could be developed and Reproducibility Yamina and Arthur discussed the concept of a target product profile (TPP) in drug development

Podcast , leaders from academia and biotech unpack what effective collaboration really looks like when developing The episode explores gpcr internalization , fluorescence-based probe design, and how functional assay development Listen This episode is for scientists and leaders who are: Navigating the transition from academic tool development co-founding the company in 2021, she has led all scientific activities, from proprietary technology development His research focuses on bottom-up chemical tool development for imaging and interrogating GPCRs and other

Unlike reversible ligands, their impact can persist long after the compound is gone — creating durable affinity experiments are interpreted—and how those interpretations quietly shape SAR, lead selection, and development Experiments: How to Avoid the Most Common Data Pitfalls Binding affinity appears straightforward: add ligand

➡️ https://www.ecosystem.drgpcr.com/receptor-activation-and-signaling/high-affinity-elr%2B-chemokine-ligands-show-g-protein-bias-over

In 2005 he started working on the development of conformational thermostabilization of GPCRs, which resulted determination of the β1-adrenoceptor and adenosine A2A receptor in multiple different conformations bound to ligands In 2016 mini-G proteins were developed as a tool for the structure determination of GPCRs in the fully

He is the Research director at INSERM with a specific interest in G protein-coupled receptors by developing He established the concept of ligand-independent functions of orphan receptors in heterodimers with other loss-of-function variants of the MT2 melatonin receptors that are associated with type 2 diabetes (TD2) development

insightful experiences in academic, hospital, and industry labs, I decided to pursue a role in business development intersection of science and business, which includes target selection, preclinical strategy and business development to elucidate the role of steroidogenesis in regulating sexual determination and adrenal and gonadal development These ligands stimulate receptor β-arrestin recruitment without activating canonical G protein signaling understand how the principles of receptor allosterism and functional selectivity can be leveraged in the development