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in a sex-selective manner and how this can influence drug discovery in the area of neurodegenerative diseases She is currently working to understand the signaling and degradation of GPCRs in disease states to help

continued reliance on cellular systems that do not adequately reflect the complexity of human tissues and disease

development of new therapeutic interventions for the alleviation of L-DOPA-induced dyskinesia in Parkinson’s Disease

categories max) Abstract categories Signaling Trafficking Metabolism Structure and Bioinformatics Health and Disease

and clinical pharmacology as scientist or PI in neonatal lupus, Cardiomyopathy, hypertension, chagas disease

My group studies the spatiotemporal dynamics of atypical inflammation and the control of disease progression

in a sex-selective manner and how this can influence drug discovery in the area of neurodegenerative diseases

studies to address the functional role of these dramatic conformational changes and the relationship to disease continues to engineer the enzyme to optimize its potential as a treatment for cocaine abuse, a debilitating disease

Sachdev is an early career researcher in the National Institute of Diabetes and Digestive and Kidney Diseases

tiny antenna-shaped structure at the cell surface with critical links to development, physiology, and disease

In 1983, he joined the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) at the

his research on biased agonism at GPCRs with a particular focus on the treatment of cardiovascular disease

Sachdev is an early career researcher in the National Institute of Diabetes and Digestive and Kidney Diseases he aims to apply this knowledge to develop novel chemical treatments for neuronal and cardiovascular diseases

a track record in exploring GPCR structure-function relationships in the context of cardiovascular disease

in a sex-selective manner and how this can influence drug discovery in the area of neurodegenerative diseases

Jurgen Wess’s lab at the National Institute of Diabetes, Digestive and Kidney Diseases (NIDDK) - NIH,

Overall, the lab works on diverse models and diseases, and has developed a wide array of tools to dissect

Our laboratory is working to help patients by developing genetically-modified mice that have disease-causing

were shown to be very effective to rescue the cell death observed in a mouse model of Huntington’s disease

second area of interest has been the elucidation of the molecular basis for a rare autosomal human disease

, molecular and cellular pharmacology, medicinal chemistry, and preclinical models of behaviour and disease work has been applied to studies encompassing neurological and psychiatric disorders, cardiovascular disease Lastly, they discussed the progress of new drugs targeting specific receptors for various diseases, with

, molecular and cellular pharmacology, medicinal chemistry, and preclinical models of behaviour and disease work has been applied to studies encompassing neurological and psychiatric disorders, cardiovascular disease Lastly, they discussed the progress of new drugs targeting specific receptors for various diseases, with

Confo Therapeutics ) as a team and project leader for antibody discovery for metabolic and inflammatory diseases

and pharmacology can provide new opportunities to improve our understanding of human physiology and disease

of growth factors and their signaling mechanisms in development, adult tissue homeostasis, and human diseases

neurotransmitters and how they might underlie brain and behavior disorders such as schizophrenia, Parkinson's disease

neurotransmitters and how they might underlie brain and behavior disorders such as schizophrenia, Parkinson's disease

physiological and pharmacological principles that underlie the workings of adhesion GPCRs in health and disease

neurotransmitters and how they might underlie brain and behavior disorders such as schizophrenia, Parkinson's disease

laboratory has gained valuable insights into the genetic basis and pathophysiology of lymphatic vascular disease , preeclampsia and sex-dependent cardiovascular disease.