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Results found for "GPCR Biology"
- Prostaglandin signaling in ciliogenesis and development
Many G-protein-coupled receptors (GPCRs) including EP4 are localized in cilia for modulating cAMP signaling
- Engineered synaptic tools reveal localized cAMP signaling in synapse assembly
Given that postsynaptic latrophilin adhesion-GPCRs drive synapse formation and produce cAMP, we suggest
- On-cell nuclear magnetic resonance spectroscopy to probe cell surface interactions
characterize ligand interactions with cell surface membrane proteins such as G-protein coupled receptors (GPCRs
- Free-Energy Simulations Support a Lipophilic Binding Route for Melatonin Receptors
"The effects of the neurohormone melatonin are mediated by the activation of the GPCRs MT1 and MT2 in
- Odorant G protein-coupled receptors as potential therapeutic targets for adult diffuse gliomas ...
and review Odorant receptors (ORs) account for about 60% of all human G protein-coupled receptors (GPCRs
- Involvement of various chemokine/chemokine receptor axes in trafficking and oriented locomotion ...
their functional activities are achieved by binding to the cell surface G protein-coupled receptors (GPCRs
- Purpose-Driven Opioid Research: Catherine Demery’s Academic Path
And GPCR pharmacology isn’t just an academic pursuit—it’s essential to understanding and responding to
- Deficiency of β-arrestin2 alleviates apoptosis through GRP78-ATF6-CHOP signaling pathway in ...
is a key protein that mediates desensitization and internalization of G protein-coupled receptors (GPCRs
- Synaptic integration of subquantal neurotransmission by co-localized G protein coupled receptors in
Colocalization of different actions of GPCRs provide synaptic integration within presynaptic terminals
- HBx induces hepatocellular carcinogenesis through ARRB1-mediated autophagy to drive the G 1/S cycle
dependent kinase inhibitor 1B; CQ: chloroquine; E2F1: E2F transcription factor 1; FBS: fetal bovine serum; GPCRs
- Why Mastering Pharmacokinetics Fundamentals Still Defines Discovery Success Today
accelerates the design–test–learn cycle Drug discovery is faster when chemistry starts aligned with biology parenteral routes bypass absorption barriers, oral and topical delivery require navigating complex biological failures are rarely about route choice alone—they reflect mismatches between scaffold properties and biological
- Exendin-4 Attenuates Remodeling in the Remote Myocardium of Rats After an Acute Myocardial ...
Exendin-4, and possibly through G protein-coupled receptors (GPCRs), increases levels of cAMP and upregulates
- Pharmacology Isn't What You Think—It's So Much More
You’ll uncover: Why pharmacology is the glue between chemistry and biology How to interpret drug behavior
- New role of β-arrestins in MOR signaling
Opioid receptors belong to class A of G protein-coupled receptors or GPCRs and signaled mainly through
- What If the Most Important Part of Your Drug Isn’t What It Binds—But What It Does?
uncover why efficacy is the unsung hero of drug discovery and how its effects depend entirely on the biological
- The Hidden Operating Cadence That’s Actually Driving Your Biotech
Timeline slips are absorbed as “part of biology” rather than examined as managerial signals.
- The Five Traps of Ignoring Kinetics
But biology isn’t tidy.
- Understanding Orthosteric Binding: The Key to Drug Action
Often, a low EC50 indicates high potency, but this isn't always the case due to various biological factors
- The One Reason Why Biotech Startups Fail More Often Than They Should
Teams that regain control do not suddenly become more confident about biology.
- TeachOpenCADD - A teaching platform for computer-aided drug design
as well as practical aspect of these topics, the platform addresses students and researchers with a biological
