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Be sure to signup for the next Virtual Cafe of Dr. GPCR on the 24th of June! This time, the GPCRdb team ( Dr. David Gloriam , Dr. Reserve your spot for free at: https://www.ecosystem.drgpcr.com/dr-gpcr-virtual-cafe/ #GPCR #GPCRs #DrGPCR

Join us for a fantastic introduction to GPCRdb with Dr. David Gloriam and Dr. Albert Kooistra. Register today: https://www.ecosystem.drgpcr.com/dr-gpcr-virtual-cafe/ #gpcr #drgpcr #virtualcafe

Did you register for our next Dr. GPCR Virtual Cafe? Register today! Addgene's Dr. research or you want to share your materials, this is the place to go. https://www.ecosystem.drgpcr.com/dr-gpcr-virtual-cafe

Join us for the first virtual cafe talk to hear about the amazing work that Dr. Brian Arey is doing. https://www.ecosystem.drgpcr.com/dr-gpcr-virtual-cafe/ #gpcr #drgpcr #virtualcafe

September 2022 "Morphine, the most widely used analgesic, relieves severe pain by activating the μ-opioid receptor (MOR), whereas naloxone, with only slight structural changes compared to morphine, exhibits inhibitory effect, and is used to treat opioid abuse. The mechanism by which the MOR distinguishes between the two is unclear. Molecular dynamics (MD) simulations on a 1-μs time scale and metadynamics-enhanced conformational sampling are used here to determine the different interactions of these two ligands with MOR: morphine adjusted its pose by continuously flipping deeper into the pocket, whereas naloxone failed to penetrate deeper because its allyl group conflicts with several residues of MOR. The endogenous peptide ligand endomorphin-1 (EM-1) underwent almost no significant conformational changes during the MD simulations. To validate these processes, we employed GIRK4S143T, a MOR-activated Gβγ-protein effector, in combination with mutagenesis and electrophysiological recordings. We verified the role of some key residues in the dynamic recognition of naloxone and morphine and identified the key residue I322, which leads to differential recognition of morphine and naloxone while assisting EM-1 in activating MOR. Reducing the side chain size of I322 (MORI322A) transformed naloxone from an inhibitor directly into an agonist of MOR, and I322A also significantly attenuated the potency of MOR on EM-1, confirming that binding deep in the pocket is critical for the agonistic effect of MOR. This finding reveals a dynamic mechanism for the response of MOR to different ligands and provides a basis for the discovery of new ligands for MOR at the atomic level." Read more at the source #DrGPCR #GPCR #IndustryNews

Hello Sweet GPCR Enthusiasts, This week at Dr. GPCR: a new podcast episode with Dr. Ben Clements, a tour of our official Dr. Ben Clements   In Episode 166, Ben Clements dives into opioid pharmacology, GPCR-targeted PAMs, and how The official Dr. GPCR Store is live! Best wishes, The Dr. GPCR Team

January 2022 "Watch our CEO Tim Dyer on AlphaStreet. In his interview, Mr. Dyer provides an overview of our #allostericmodulator pipeline and the potential $4 billion market for

Ben Clements has been there. This simple advice, passed on to Ben in grad school, has helped him stay sane, focused, and impactful But as Ben points out, burnout is real, and it doesn’t make you better. Imposter Syndrome and Finding Your Place Ben shares the moment he realized he mattered, when he was : Try the Crazy Idea When a collaborator offered a neuroma model (one where opioids usually fail), Ben

Ben Clements has. And that moment, silly as it was, says a lot about how he sees science. Lab Culture Isn’t Just About Productivity Ben and his colleagues work hard in the lab. And we need that to do our best work.” – Ben Clements Mentorship Is the Engine of Science Ben chose When undergraduate students enter the lab, Ben doesn’t just teach them how to pipette, he teaches why

Alexander Ball and Dr. Chia-Yi Lin, began. A word that admits what it doesn’t know Much of that trust problem, Dr. Dr. Dr. Lin arrived from a different door. Listen to the full conversation with Dr. Ball and Dr. Lin Watch the webinar recording with Dr. Ball

Dr. GPCR University Save the date for our upcoming workshop, starting May 9th, 2024, featuring Dr.  Under Dr. Hoare's expert guidance, you will gain invaluable skills in data analysis. Dr. Terry Kenakin's "Applying Pharmacology to Drug Discovery" course at Dr. Dr. controls midgut development in Drosophila Karuna Therapeutics announces that is now part of Bristol Myers

It's spring break at Dr. Learn more about Live Masterclasses ➤ Partner Webinars Eurofins DiscoverX (Dr. GeneTex (Dr. Alex Ball)  — A reagent gap that holds back the biology. Details coming soon. Next Week in Boston The Dr. GPCR community gathers in person next week. Come find us ➤ About Dr. GPCR Dr. GPCR is the intelligence and community for GPCR scientists.

In Episode 168 of the Dr. GPCR Podcast, Dr. And that mindset is precisely what makes their new partnership with Dr. GPCR so powerful. ” — Dr. That’s the mission. ” — Dr. Maria Majellaro Now, as official partners of the Dr. Keyword Cloud:   GPCR data platform , fluorescent ligands , assay development , GPCR research community , Dr

Plus, check out the latest Dr. GPCR tools and key moves in the biotech world. Dr. Become a Dr. GPCR Ambassador - Share & refer with Dr. GPCR.   Join the Affiliate Program     Your Shortcut to Dr. The Dr. Best wishes, The Dr. GPCR Team

Dr. Maria Majellaro’s story, shared in Episode 168 of the Dr. ” — Dr. Maria Majellaro Maria didn’t always know she’d end up in a startup. ” — Dr. With the new  Dr. . 👉 Explore Celtarys’ tools and partnership with Dr.

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, we’re spotlighting Celtarys Research, our newest partner, featured in a blog and podcast with CSO Dr After 40+ years and 250 publications, Dr. Dr. Explore Terry's Corner From Chemistry Lab to GPCR Partner – New Podcast with Celtarys Dr. Stay curious, The Dr. GPCR Team

As a valued Dr. featuring:   A short, focused video A concise written summary with key takeaways Handpicked references by Dr Your Exclusive Premium Member Benefit:   As a thank you for your continued support of the Dr. GPCR Ecosystem, we're giving Dr. Warmest Regards, The Dr. GPCR Team & Terry’s Desk

GPCR Podcast: Leadership, Impact, and GPCR Signaling with Dr. Dr. Yamina’s open letter reflects on how Dr. I wish Dr. No matter where you are in your GPCR journey, Dr.

The Corner comes will live monthly AMA sessions with Dr. Kenakin. GPCR Updates Learn Pharmacology That Drives Discovery  – From Dr. Explore Dr. This blog post breaks down Dr. Stay curious,   The Dr. GPCR Team

Secure Your Access Now ➤ 🗣️ “Thank you for bringing this (Principles of Pharmacology I) course with Dr I wish Dr. best for the sake of promoting more educational opportunities that are sorely needed in the field” — Dr GPCR University Learner Dr. GPCR Podcast - Surviving Discovery’s Gauntlet Dr. The Dr. GPCR Team Read Full Edition ➤

In this Terry’s Corner lesson, Dr. Join before year-end to secure both. 👉   Join Terry's Corner Before Dec 31st, 2025 🎧 Dr. Hudson 🎧 Catch up on Part 2 with Dr. GPCR Year in Review: Carrying Better Experiments Into 2026 As 2025 closes, the Dr. Beyond access, Premium sustains the nonprofit mission behind Dr.

GPCR Colleagues & Curiosity-Driven Minds, We’re starting with exciting Dr. sharpen your skills with our new on-demand course, Techniques for Effective Lead Optimization with Dr Dr. Catch up on past Dr. Stay curious, The Dr. GPCR Team

. -            Dr. Wendy Young’s talk, during session 3 on day 2, was also incredible. . -            Dr. Wednesday was a key day for Maria, as she got to participate in a panel discussion alongside Dr. Shoichet, Dr. Luc Van Hijfte and Dr. Wendy Young. Amanda Dombrowski from Abbvie, Dr. Charles Yeung from Merck and Dr.

Dr. GPCR Podcast: Chemical Probes for GPCR Imaging with Dr. In this episode, Dr. I will keep Dr. GPCR and the offered resources in my work sphere." Donate : https://www.ecosystem.drgpcr.com/donate Dr.

For Dr. In this episode of the Dr. ” — Dr. Maria Majellaro Maria’s career didn’t start with a desire to launch a company. Celtarys Research, now partnering with Dr. ____________ Keyword Cloud:   GPCR drug discovery , GPCR research community , medicinal chemistry , Dr

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This week at Dr. Dr. Led by Dr. Access the Course Hacking GPCRs: A Toolkit for Systems Biology – New Podcast Episode In Episode 167, Dr Tom Sakmar and Dr.

Terry Hébert joins the Dr. Dr. Kenakin is in the room. Sign up to get access ➤ Dr. content had enough depth to satisfy the hunger for theory while being full of practical knowledge." — Dr GPCR University Learner About Dr. GPCR Dr.

That’s why this week at Dr. delays key milestones. 🗣️ “Thank you for bringing this (Principles of Pharmacology I) course with Dr I wish Dr. Ingo Hartung : State-of-the-art design of small molecule drugs, including PROTACs Dr. Get The Full Story ➤ Why Dr. GPCR Premium Membership Gives You an Edge Dr.