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Join us for the first virtual cafe talk to hear about the amazing work that Dr. Brian Arey is doing. https://www.ecosystem.drgpcr.com/dr-gpcr-virtual-cafe/ #gpcr #drgpcr #virtualcafe

September 2022 "Morphine, the most widely used analgesic, relieves severe pain by activating the μ-opioid receptor (MOR), whereas naloxone, with only slight structural changes compared to morphine, exhibits inhibitory effect, and is used to treat opioid abuse. The mechanism by which the MOR distinguishes between the two is unclear. Molecular dynamics (MD) simulations on a 1-μs time scale and metadynamics-enhanced conformational sampling are used here to determine the different interactions of these two ligands with MOR: morphine adjusted its pose by continuously flipping deeper into the pocket, whereas naloxone failed to penetrate deeper because its allyl group conflicts with several residues of MOR. The endogenous peptide ligand endomorphin-1 (EM-1) underwent almost no significant conformational changes during the MD simulations. To validate these processes, we employed GIRK4S143T, a MOR-activated Gβγ-protein effector, in combination with mutagenesis and electrophysiological recordings. We verified the role of some key residues in the dynamic recognition of naloxone and morphine and identified the key residue I322, which leads to differential recognition of morphine and naloxone while assisting EM-1 in activating MOR. Reducing the side chain size of I322 (MORI322A) transformed naloxone from an inhibitor directly into an agonist of MOR, and I322A also significantly attenuated the potency of MOR on EM-1, confirming that binding deep in the pocket is critical for the agonistic effect of MOR. This finding reveals a dynamic mechanism for the response of MOR to different ligands and provides a basis for the discovery of new ligands for MOR at the atomic level." Read more at the source #DrGPCR #GPCR #IndustryNews

E Gloriam ,   Alexander S Hauser GPCRdb in 2025: adding odorant receptors, data mapper, structure similarity E Gloriam , et al. Dr. GPCR Kicked Off as a Podcast... Direct line to the Dr. Jude Children's Research Hospital Welcomes Dr.

The call from David — the glowing islet — created a pivot the team couldn’t ignore. He learned tissue complexity from David; David picked up the quirks of acetonitrile.  🎧 Listen to the full episode https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/chemical-probes-for-gpcr-imaging-and-internalization If JB's story resonates 🎧 Listen to part 1 of this series with Dr. David Hodson

This week's highlight includes congrats to: David A Cooper, David Minh, et al., for their research on Join our upcoming Dr. GPCR University hands-on workshop with Dr.  The workshop includes: Four x 2-hour Zoom sessions One-on-one meeting with Dr. Hoare Access to Dr. Dr. Dr.

Dr. Drs. Lukas Grätz, David Gloriam, and Gunnar Schulte’s research on Unveiling pathway selectivity in Frizzleds In case you missed it, recordings of the Dr. Robert Lefkowitz Lab Postdoc Fellow - Dr.

In this Terry’s Corner lesson, Dr. Maria Majellaro, Johannes Broichhagen, and David Hodson discuss GLP-1 receptor probes, fluorescence-based Hudson 🎧 Catch up on Part 2 with Dr. GPCR Year in Review: Carrying Better Experiments Into 2026 As 2025 closes, the Dr. Beyond access, Premium sustains the nonprofit mission behind Dr.

In this week’s lesson, Dr. Access this week’s key insight ➤ Dr. David Hodson walks through how his team uses fluorescence tools and chemically engineered ligands to Dr. See you in the Ecosystem, Dr. GPCR Team

David Hodson needed molecules that were only one synthetic step beyond what JB was already making. David brought deep experience in islet biology, calcium imaging, and tissue physiology. , you’ll love the full conversation. 🎧 Listen to the full episode https://www.ecosystem.drgpcr.com/dr-gpcr-podcast chemical-probes-for-gpcr-imaging-and-internalization If JB's story resonates 🎧 Listen to part 1 of this series with Dr David Hodson

Featuring logos from Dr. GPCR and Revvity. Dr. David Parker spent years designing rare-earth europium probes. Want to hear Dr. Trinquet tell the story in his own words? GPCR   Dr. GPCR X Revvity Collaboration ⸻ Want more like this? 👉 Join the Dr.

In his collaboration with David Hodson, every major leap—from early ligand design to GPCR visualization  🎧 Listen to the full episode https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/chemical-probes-for-gpcr-imaging-and-internalization If JB's story resonates 🎧 Listen to part 1 of this series with Dr. David Hodson

Dr. Frame your strategy, then let the serendipity occur.” — Dr. It’s the product of layered collaborations—with Durham University chemist David Parker on the probe chemistry Want to hear Dr. Trinquet tell the story in his own words? GPCR   Dr. GPCR X Revvity Collaboration ⸻ Want more like this? 👉 Join the Dr.

For Dr. However, Trinquet’s team, in collaboration with Professor David Parker from Durham University, cracked You’re just changing how bright it is—and how long it glows,” said Dr. Eric Trinquet. Listen to the full podcast episode here ⸻ More about Revvity pHSense Reagents GPCR Reagents Revvity on Dr GPCR   Dr. GPCR X Revvity Collaboration ⸻ Want more like this? 👉 Join the Dr.

Watch Episode #177 The Experiment That Was Never Meant to Succeed When David Hodson’s lab teamed up with this story resonates with your work or curiosity, go deeper. 🎧 Listen to the full conversation with Dr David Hodson

Welcome to this week’s Dr. multiple transducers; plus obesity-drug program milestones and company pipeline updates. 🔍 This Week in Dr Kenakin     💎 $2999/year — one conference cost = 12 months of expert training  Premium Dr. For Dr. Working closely with Professor David Parker of Durham University, Trinquet’s group cracked the scaffold

It's spring break at Dr. Learn more about Live Masterclasses ➤ Partner Webinars Eurofins DiscoverX (Dr. GeneTex (Dr. Alex Ball)  — A reagent gap that holds back the biology. Details coming soon. Next Week in Boston The Dr. GPCR community gathers in person next week. Come find us ➤ About Dr. GPCR Dr. GPCR is the intelligence and community for GPCR scientists.

Plus, check out the latest Dr. GPCR tools and key moves in the biotech world. Dr. Become a Dr. GPCR Ambassador - Share & refer with Dr. GPCR.   Join the Affiliate Program     Your Shortcut to Dr. The Dr. Best wishes, The Dr. GPCR Team

In Episode 168 of the Dr. GPCR Podcast, Dr. And that mindset is precisely what makes their new partnership with Dr. GPCR so powerful. ” — Dr. That’s the mission. ” — Dr. Maria Majellaro Now, as official partners of the Dr. Keyword Cloud:   GPCR data platform , fluorescent ligands , assay development , GPCR research community , Dr

Dr. Maria Majellaro’s story, shared in Episode 168 of the Dr. ” — Dr. Maria Majellaro Maria didn’t always know she’d end up in a startup. ” — Dr. With the new  Dr. . 👉 Explore Celtarys’ tools and partnership with Dr.

Enter a long-term collaboration with chemist Dr. this story resonates with your work or curiosity, go deeper. 🎧 Listen to the full conversation with Dr David Hodson

Hello Sweet GPCR Enthusiasts, This week at Dr. GPCR: a new podcast episode with Dr. Ben Clements, a tour of our official Dr. Scroll down for the science, the strategy, and the sweet stuff 🍬 Dr. The official Dr. GPCR Store is live! Best wishes, The Dr. GPCR Team

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, we’re spotlighting Celtarys Research, our newest partner, featured in a blog and podcast with CSO Dr After 40+ years and 250 publications, Dr. Dr. Explore Terry's Corner From Chemistry Lab to GPCR Partner – New Podcast with Celtarys Dr. Stay curious, The Dr. GPCR Team

As a valued Dr. featuring:   A short, focused video A concise written summary with key takeaways Handpicked references by Dr Your Exclusive Premium Member Benefit:   As a thank you for your continued support of the Dr. GPCR Ecosystem, we're giving Dr. Warmest Regards, The Dr. GPCR Team & Terry’s Desk

GPCR Podcast: Leadership, Impact, and GPCR Signaling with Dr. Dr. Yamina’s open letter reflects on how Dr. I wish Dr. No matter where you are in your GPCR journey, Dr.

The Corner comes will live monthly AMA sessions with Dr. Kenakin. GPCR Updates Learn Pharmacology That Drives Discovery  – From Dr. Explore Dr. This blog post breaks down Dr. Stay curious,   The Dr. GPCR Team

Secure Your Access Now ➤ 🗣️ “Thank you for bringing this (Principles of Pharmacology I) course with Dr I wish Dr. best for the sake of promoting more educational opportunities that are sorely needed in the field” — Dr GPCR University Learner Dr. GPCR Podcast - Surviving Discovery’s Gauntlet Dr. The Dr. GPCR Team Read Full Edition ➤

Burger , Arthur Christopoulos , David M. Gain access to over 500 minutes of recorded classes in our  GPCR courses   taught by Drs. Join us for an exciting discussion with Dr. live and work  in a developing country, please complete this form to enjoy complimentary access to Dr

GPCR Colleagues & Curiosity-Driven Minds, We’re starting with exciting Dr. sharpen your skills with our new on-demand course, Techniques for Effective Lead Optimization with Dr Dr. Catch up on past Dr. Stay curious, The Dr. GPCR Team

. -            Dr. Wendy Young’s talk, during session 3 on day 2, was also incredible. . -            Dr. Wednesday was a key day for Maria, as she got to participate in a panel discussion alongside Dr. Shoichet, Dr. Luc Van Hijfte and Dr. Wendy Young. Amanda Dombrowski from Abbvie, Dr. Charles Yeung from Merck and Dr.