She has advanced the use of computational methods to meet the challenges of designing therapeutics with molecular dynamics simulation methods with emphasis on application to G-protein coupled receptors and drug design." GPCR Unlock the Full Dr. GPCR Podcast? Leave a Review.

GPCR Affiliate Program and earn commissions by helping connect the global GPCR community. Share our ecosystem, courses, and events to advance drug discovery together. Dr. GPCR community. The Ecosystem is designed for all GPCR professionals to have an affordable and highly effective way to GPCR Ecosystem?

agonism - a first-in-kind finding at wild-type FFA2 and its implications for biased ligand campaign design unexplored opportunity in existing drug pipelines Antibody therapeutics for GPCRs - the pipeline case The aha moment was not the result itself but recognizing what it meant for how you could design the campaign Almost no company with an approved GPCR-targeting drug has gone back to look at what common receptor It was not the experiment she had designed.

His research focuses on novel paradigms of drug action at GPCRs, particularly allosteric modulation and the understanding and application of allosteric modulation. - Arthur will work on designing ligands design principles. GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses GPCR Podcast? Leave a Review.

pharmacology and drug design. Drug discovery needs modulators more than it needs hammers Arey's philosophy of drug discovery is grounded for a therapeutic strategy built around modulators that can be combined, rather than single agents designed He continues to pioneer in drug discovery studying GPCRs and other target classes. GPCR Podcast? Leave a Review.

Michelle Halls shares how dissecting the spatial organization of GPCR signaling opens new doors in drug the Guest Michelle Halls is an Associate Professor at Monash University and Deputy Theme Leader of Drug GPCR Premium . GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses GPCR Podcast? Leave a Review.

structural stabilization and live-cell conformational reporting The limits and promise of biased agonism in drug effect, physiological examples of the beta-arrestin-biased receptors pharmacologists have been trying to design The neat bifurcation between G-protein and beta-arrestin signaling that drove early opioid receptor drug design has not held up cleanly in subsequent studies. Shukla's lab designed antibody fragments to stabilize GPCR–beta-arrestin complexes for structural studies

drug discovery . circuits — insights that inform next-generation functional assay development and translational therapeutic design Why this matters How receptor distribution in islets and brain circuits shapes incretin hormone drug collaborative chemistry enabled in designing receptor-targeted fluorescent ligands The moment when structural GPCR Podcast? Leave a Review.

architecture - what a dimer with no prior blueprint looks like What remains unsolved: why drug discovery Drug discovery's real bottleneck is not structural Tate is direct about where the field now stands: accumulating GPCR structures is no longer the limiting step in drug discovery. GPCR Ecosystem Unlock the Full Dr. GPCR Podcast? Leave a Review.

Aurélien Rizk is a scientist and entrepreneur in drug discovery. Before focusing on the development of innovative mathematical modeling and simulation methods for drug Interdisciplinary Teamwork and Drug Development Yamina Berchiche and Aurelien Rizk emphasized the significance of interdisciplinary teamwork in drug and technology development, noting the challenges of communication Aurelien Rizk confirmed his attendance at the upcoming GPCR-Targeted Drug Discovery Summit in Boston.

“I think I don’t have a linear trajectory… the beauty of seeing molecule design and reactions—thinking Alessandro Nicoli He studied pharmaceutical chemistry in Padua, where his fascination with molecular design “I got to know computational chemistry through a project on BCL2 proteins and drug discovery… I was in close to experimental structures, provided a powerful starting point for docking, dynamics, and ligand design—especially drug discovery pipelines.

From her early doubts to designing preclinical models of fentanyl and xylazine overdose, she reflects pharmacologist—led her to investigate how these drugs shut down breathing in different ways. Who Should Listen This episode is especially relevant for: GPCR drug discovery scientists Respiratory GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses GPCR Podcast? Leave a Review.

engaged in researching molecular mechanisms that govern human (patho-)physiology and their interplay with drugs I aim to discover new therapeutic approaches, and druggable molecules or refine canonical drug targets to create drugs with fewer adverse effects. GPCR Unlock the Full Dr. GPCR Podcast? Leave a Review.

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GPCR Podcast, chemical biologist Dr. drug discovery . He explains what chemical design can solve that antibodies can’t, how to validate functional assay systems Why this matters How a chemist with zero biology training became a leader in GPCR probe design. GPCR Podcast? Leave a Review.

from the endoplasmic reticulum, to the experimental frameworks that made biased agonism a credible drug mutants, and biosensor platforms that helped establish functional selectivity and biased agonism as drug to our understanding of this major class of drug targets. GPCR Ecosystem Unlock the Full Dr. GPCR Podcast? Leave a Review.

Learn about course content, instructors, and how to advance your expertise in drug discovery. GPCR University Dr. Our flexible course formats are designed to fit your time, depth, and teaching goals — whether you’re GPCR University Instructor and help move GPCR science forward. Aside from his vast experience in drug development, not to mention his extensive publication record,

target for drug development. and drug development technology. GPCR Ecosystem Unlock the Full Dr. GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses GPCR Podcast? Leave a Review.

pneumocytes, beta-2 receptors, and the asthma parallel The ethics of acting on conviction — off-label drug gas pedals and brakes" frame — a lens that has quietly shaped how he reads both disease mechanism and drug GPCR Ecosystem Unlock the Full Dr. GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses GPCR Podcast? Leave a Review.

biology and for the identification of drug targets and future drug development. which has important functions in hemostasis, thrombosis, inflammation, and cancer and is an important drug GPCR Ecosystem Unlock the Full Dr. GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses GPCR Podcast? Leave a Review.

Obesity and GLP-1 biology changed that, and the largest target class is once again at the front of drug brings more than twenty years of industry experience across diverse cell-based assays, supporting client drug to the front of drug discovery De-orphanizing GPCRs, including receptors stuck in the endoplasmic reticulum GPCRs never left; the attention did. GPCR Podcast? Leave a Review.

Join us in strengthening the global GPCR community. Dr GPCR is a 501(c)(3) non-profit. 501(c)(3) Non-Profit Help Us Build a Global Home for GPCR Science GPCR Ecosystem open, reliable, and thriving. GPCR University Premium to a colleague, mentee, or even yourself — the gift of cutting-edge GPCR education more effective drugs for everyone.

targets — a top-down rethink for drug discovery. << Back to podcast list Strategic Partner(s) GPCRs “We’re using outdated drugs. There are more elegant GPCR targets waiting to be explored.” He’s fascinated by transgenerational epigenetics — how parental pain, diet, or drug exposure can leave GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses GPCR Podcast? Leave a Review.

Juan José Fung is a Principal Scientist at GPCR Therapeutics, Inc , a drug discovery company focused spent significant time in the industry studying membrane proteins, antibodies, and HTS methods for drug Juan José Fung on the web LinkedIn GPCR Therapeutics Dr. GPCR Ecosystem Unlock the Full Dr. GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses GPCR Podcast? Leave a Review.

researchers cannot determine why promising preclinical findings did not translate, cannot adjust future trial designs still good drug targets? GPCR Ecosystem Unlock the Full Dr. GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses GPCR Podcast? Leave a Review.

and in vitro drug discovery. Icahn School of Medicine at Mount Sinai in NYC, where I have been working on structure-function and drug GPCR Ecosystem Unlock the Full Dr. GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses GPCR Podcast? Leave a Review.

Key Insights from the Conversation Challenge trials don't work without a reliable drug. Dr. design can responsibly change. 90 vaccine candidates is a number about effort, not probability. GPCR Ecosystem Unlock the Full Dr. GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses GPCR Podcast? Leave a Review.

Cardarelli is a drug development leader with extensive experience driving drug discovery teams in bringing She has extensive experience working with Biologics, and Antibody Drug Conjugates as well as experience GPCR Ecosystem Unlock the Full Dr. GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses GPCR Podcast? Leave a Review.

Internalization is a design choice, not a side effect. it 09:27 What chronic dosing does to the receptor — tolerance, internalization, downregulation 14:17 Designing GPCR Ecosystem Unlock the Full Dr. GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses GPCR Podcast? Leave a Review.

<< Back to podcast list Strategic Partner(s) GPCR location matters with Dr. In my PhD, I studied the nanoscale spatial organization of G protein-coupled receptors (GPCRs) at the revealed heterogeneous spatial patterns of receptor density and activation, that are modulated in a drug-dependent GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses GPCR Podcast? Leave a Review.