Pathway Pharmacological Fingerprint To obtain a pharmacological fingerprint (or profile) for GPCR therapeutics Expanding the Druggable Target Space Through Bias Beyond refining the pharmacology of established targets Journal of Pharmacology and Experimental Therapeutics, 314(3), 1195–1201. https://doi.org/10.1124/jpet Journal of Pharmacology and Experimental Therapeutics, 344 (3), 708–717. https://doi.org/10.1124/jpet Journal of Pharmacology and Experimental Therapeutics, 335 (3), 572–579. https://doi.org/10.1124/jpet

Breakthroughs this week: C. elegans avoids EGCG via SRXA-7 GPCR; a bidirectional GPCR switch modulates See the true  pharmacology:  Lower sensitivity to uncover partial agonism and compare relative efficacy classified industry updates, priority event alerts, vetted jobs, and commentary that connects dots across pharmacology GPCR scientists, translational pharmacologists, discovery teams, and decision-makers who need fast, curated GPCR innovation is accelerating.

with pharmacological rigor. That opened the door to something rare in functional pharmacology: plate-based GPCR internalization tracking internalization of endogenous GLP-1 receptors in rat beta cells—with no overexpression, no imaging, and no pharmacological GPCR   Dr. GPCR X Revvity Collaboration ⸻ Want more like this? 👉 Join the Dr. GPCR Premium Ecosystem  for behind-the-scenes access to GPCR innovators, exclusive deep-dives, and practical

For decades, GPCRs have been the cornerstone of pharmacology. Projects in his group often begin with either: A new GPCR structure  ripe for exploration, or A pharmacological Carlsson’s group integrates modeling with mechanistic pharmacology. , and scalable experimental assays is shrinking the gap between modeling and pharmacology. Forward The Carlsson lab exemplifies how c omputational biochemistry can meaningfully impact real-world pharmacology

Upcoming events:  GPCR-TDD Europe; Pharmacology 2026. Researchers navigating complex datasets, balancing innovation with assay rigor, or working across chemistry–pharmacology–physiology GPCR scientists, translational pharmacologists, biotech discovery teams, and decision-makers who need GPCR innovation is accelerating. GPCR Team

Pharmacology isn’t only about ligands, receptors, and downstream G protein signaling—it’s also about The Hidden Lever in GPCR Research In GPCR pharmacology, the conversation often centers on ligand properties—affinity Clarify whether observed effects reflect true pharmacology or assay artifacts . From Bench Insight to Strategic Advantage Terry Kenakin’s decades of pharmacology leadership converge A growing on-demand library  of expert pharmacology lessons to revisit anytime.

Are you ready to truly understand how pharmacologists predict whole-body drug response from a single straight to it:   Why models are vital for translating lab data into clinical forecasts The 4 types of pharmacologic GPCR News.   Elevate your pharmacology expertise. Unlock "Pharmacologic Models" now

His work spans deep academic research, startup life, and the application of machine learning and pharmacology to GPCR drug discovery. Superluminal Medicines: AI/ML Meets GPCR Pharmacology As Ajay continued to explore how GPCR signaling Despite decades of progress in structural biology and pharmacology, predicting how  a GPCR will respond Takeaway: Ajay Yekkirala’s story is not just about GPCR science or startup success.

GPCR , the global nonprofit platform dedicated to advancing GPCR science through education, community GPCR Ecosystem. GPCR Podcast To mark the spotlight, Dr. GPCR  invited Dr. Eric Trinquet  to the Dr. GPCR. GPCR Dr.

GPCRs are one of the most important families of therapeutic targets in the pharmaceutical industry Approximately one-third of the drugs currently in clinical use are GPCR ligands. Trends in GPCR Drug Discovery: New Agents, Targets and Indications. British J Pharmacology 2007 , 152 (4), 429–448. https://doi.org/10.1038/sj.bjp.0707332 . (4) Barbazán Pharmacological Research 2021 , 174 , 105970. https://doi.org/10.1016/j.phrs.2021.105970 . (6) Miranda-Pastoriza

One of its first pillars, Terry’s Pharmacology Corner , led by Dr. Through Terry’s Pharmacology Corner , he shares decades of expertise in an accessible, on-demand format Terry Kenakin , a pioneer who helped shape modern pharmacology and deepen our understanding of GPCR function GPCR About Dr. GPCR Dr. Related Links 🔗 Explore Terry’s Pharmacology Corner → TerryKenakin.com 📧 Connect with us →   Hello@

Sudarshan Rajagopal and their lab team study on 'Location bias: A "Hidden Variable" in GPCR pharmacology GPCR Symposium on 'GPCRs as Therapeutic Modalities'. , and more Key Aspects of Modern GPCR Drug Discovery Location bias: A "Hidden Variable" in GPCR pharmacology Postdoc Research Associate Director, Regulatory Affairs Research Scientist/Senior Scientist I - Molecular Pharmacology GPCR Ecosystem

of Pharmacology I course! Don’t miss this opportunity to advance your knowledge and skills in pharmacology! pharmacology and apply it to their research in academia and industry. Emerging Voices in GPCR Biology in Special Issue of Molecular Pharmacology GPCR Events, Meetings, and GPCR Jobs HIGHLIGHT Research Associate - Professor Graeme Milligan HIGHLIGHT Postdoc in Molecular Pharmacology

partnership built on trust and curiosity — reshaped both careers and helped unlock a new generation of GPCR How a Collaboration Led to a GPCR Imaging Breakthrough JB didn’t set out to contribute to a GPCR imaging It was the start of a scientific partnership with the potential to shift how GPCRs could be visualized How Chemical Probes Transformed GPCR Imaging and Outperformed Antibodies As JB continued exploring the Designing Reliable GPCR Imaging Tools for Real Biological Systems Success brought new challenges.

In the high-stakes world of GPCR drug discovery , breakthrough science isn't enough. GPCR, we recognized this core problem. This is the essence of de-risking GPCR programs through operational excellence. the entire GPCR program as a single, interconnected entity. The GPCR Precision Blueprint is more than a concept.

Interdisciplinary design isn’t optional in GPCR imaging. It’s the catalyst. And the most striking validation came from in vivo GPCR imaging. They unlocked pharmacologically relevant insights that were previously inaccessible. Strong GPCR imaging tools come from strong interdisciplinary relationships.  🎧 Listen to the full episode https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/chemical-probes-for-gpcr-imaging-and-internalization

Hi GPCR Community, If you work on GPCR discovery, you already know: early signals can mislead, and timing discovery and translational pharmacology. GPCR scientists, translational pharmacologists, biotech discovery teams, platform company leaders, and Access this week’s full Premium Edition here ➤ What our members say 🗣️ "The best pharmacology teacher Also super-valuable for those of us learning how to teach pharmacology." — DrGPCR University Attendee

Broichhagen aka JB, the goal was bold and elegant: Create a photo-switchable ligand to remotely control GPCR They had a tool that did bind the GPCR… but not in the light-controlled way they wanted. The Moment a Failed Tool Became a GPCR Imaging Breakthrough What the compound did reliably do was label This solved a long-standing problem in GPCR biology: You can't understand signaling if you can’t see  The Larger Lesson for Scientists and Innovators This story isn’t just about a GPCR imaging tool.

agricultural settings inspired him to train in veterinary medicine, where he was introduced to physiology and pharmacology GPCRs Re-Enter the Story — Not as Theory, but as Tools GPCRs have always been powerful drug targets — That partnership eventually produced fluorescent GPCR tools  that allow researchers to visualize GPCR Emerging direction: Multi-target GPCR + myostatin-pathway combinations. Can GPCRs act as “delivery ZIP codes” for targeted therapies?

August 2022 "G protein-coupled receptors (GPCRs) are the largest family of membrane receptors that serve Classically, GPCR internalization has been considered to lead to receptor desensitization. Here, this review summarizes different PTMs in GPCR internalization and analyzes their significance in , which will offer new insights into the regulatory mechanism of GPCR signaling and novel drug targets Read more at the source #DrGPCR #GPCR #IndustryNews

explicitly interested in GPCR signaling... but the thing about GPCRs... is you always kind of end up landing at a GPCR as a major target." GPCRs in the Background, But Always Present Even though his primary focus wasn’t GPCRs themselves, Serafini the core mediator  — demonstrating the reach of these signaling pathways beyond classical receptor pharmacology Takeaway Forget what you think you know about GPCR drug targets.

Corner , our founder Yamina Berchiche works closely with organizations to help them navigate receptor pharmacology Push the boundaries  of receptor pharmacology and its real-world applications.   📚 Terry’s Corner — The Only On-Demand Pharmacology Hub with Dr. GPCR  community, you already know about Terry’s Corner  — our exclusive, on-demand pharmacology series where Terry Kenakin breaks down receptor pharmacology, functional selectivity, and ligand bias in a

Exploring the Hidden Dynamics: How Kinetics Reveals What Equilibrium Conceals in GPCR Research. Career opportunities:  Snapshot of roles spanning PhD entry points to senior translational pharmacology—Protein Expression, Drug Discovery Scientist, and Staff Scientist in Molecular Pharmacology—curated with notes GPCR scientists, translational pharmacologists, biotech discovery teams, and decision-makers who need GPCR innovation is accelerating.

biology and pharmacology Dr. Materials Access to the private group Certificate of participation Learn the essentials: Measuring the pharmacologic synthetic biology for human G protein-coupled receptor biology and pharmacology Industry News Muscarinic - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology GPCR Jobs NEW Postdoc in GPCR mechanosensing GPCR Ecosystem

GPCR, the global knowledge hub for G protein-coupled receptor (GPCR) research and education, is proud GPCR. GPCR Dr. GPCR is a nonprofit organization connecting the global GPCR community through training, curated news, platform enables rapid generation of conjugates, such as labeled ligands, with excellent affinity and pharmacological

GPCR University workshop on Advanced Data Analysis for GPCR Pharmacology, led by the esteemed Dr. GPCR Matchmaking Read Mark's job spotlight article for a Principal Scientist in In Vitro Pharmacology Mark recently discussed this exciting opportunity with Beth Fleck, Director of In Vitro Pharmacology World Congress of Basic and Clinical Pharmacology 2026 GPCR Jobs HIGHLIGHT Principal Scientist, In vitro pharmacology NEW Senior Scientist - Receptor Pharmacology NEW PostDoctoral Scientist Senior Research

Samuel Hoare on Advanced data analysis for GPCR pharmacology, which will be held on Thursdays between World Congress of Basic and Clinical Pharmacology 2026 GPCR Jobs Senior Associate Scientist - Global Research Unit Postdoctoral Scholar – Synaptic physiology, optical imaging, substance use disorder, pharmacology Research Fellow Postdoctoral Fellow – Molecular Pharmacology of Feeding Behavior Join Dr. GPCR Ecosystem

and a research associate/scientist in in vitro pharmacology. GPCR Podcast : The Future of GPCR Drug Discovery with Molecular Modeling The field of GPCR research is “The best pharmacology teacher (Dr. Also super-valuable for those of us learning how to teach pharmacology” — Dr. GPCR scientists, translational pharmacologists, biotech drug discovery teams, and decision-makers who

Recent advances in structural biology and pharmacology have revealed the existence of allosteric sites within GPCRs' intracellular domains. Allosteric modulators targeting GPCRs can display one or more of the following pharmacological characteristics GPCR activity, enabling greater specificity and fewer side effects. their allosteric influence, an attribute that offers a considerable degree of adjustability in terms of pharmacological

GPCR Virtual Cafe. This time with none other than Dr. https://www.ecosystem.drgpcr.com/dr-gpcr-virtual-cafe/ #gpcr #drgpcr #virtualcafe