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Broichhagen aka JB, the goal was bold and elegant: Create a photo-switchable ligand to remotely control GPCR They had a tool that did bind the GPCR… but not in the light-controlled way they wanted. The Moment a Failed Tool Became a GPCR Imaging Breakthrough What the compound did reliably do was label This solved a long-standing problem in GPCR biology: You can't understand signaling if you can’t see  The Larger Lesson for Scientists and Innovators This story isn’t just about a GPCR imaging tool.

biology and pharmacology Dr. Materials Access to the private group Certificate of participation Learn the essentials: Measuring the pharmacologic synthetic biology for human G protein-coupled receptor biology and pharmacology Industry News Muscarinic - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology GPCR Jobs NEW Postdoc in GPCR mechanosensing GPCR Ecosystem

agricultural settings inspired him to train in veterinary medicine, where he was introduced to physiology and pharmacology GPCRs Re-Enter the Story — Not as Theory, but as Tools GPCRs have always been powerful drug targets — That partnership eventually produced fluorescent GPCR tools  that allow researchers to visualize GPCR Emerging direction: Multi-target GPCR + myostatin-pathway combinations. Can GPCRs act as “delivery ZIP codes” for targeted therapies?

explicitly interested in GPCR signaling... but the thing about GPCRs... is you always kind of end up landing at a GPCR as a major target." GPCRs in the Background, But Always Present Even though his primary focus wasn’t GPCRs themselves, Serafini the core mediator  — demonstrating the reach of these signaling pathways beyond classical receptor pharmacology Takeaway Forget what you think you know about GPCR drug targets.

Recent advances in structural biology and pharmacology have revealed the existence of allosteric sites within GPCRs' intracellular domains. Allosteric modulators targeting GPCRs can display one or more of the following pharmacological characteristics GPCR activity, enabling greater specificity and fewer side effects. their allosteric influence, an attribute that offers a considerable degree of adjustability in terms of pharmacological

Exploring the Hidden Dynamics: How Kinetics Reveals What Equilibrium Conceals in GPCR Research. Career opportunities:  Snapshot of roles spanning PhD entry points to senior translational pharmacology—Protein Expression, Drug Discovery Scientist, and Staff Scientist in Molecular Pharmacology—curated with notes GPCR scientists, translational pharmacologists, biotech discovery teams, and decision-makers who need GPCR innovation is accelerating.

GPCR, the global knowledge hub for G protein-coupled receptor (GPCR) research and education, is proud GPCR. GPCR Dr. GPCR is a nonprofit organization connecting the global GPCR community through training, curated news, platform enables rapid generation of conjugates, such as labeled ligands, with excellent affinity and pharmacological

Samuel Hoare on Advanced data analysis for GPCR pharmacology, which will be held on Thursdays between World Congress of Basic and Clinical Pharmacology 2026 GPCR Jobs Senior Associate Scientist - Global Research Unit Postdoctoral Scholar – Synaptic physiology, optical imaging, substance use disorder, pharmacology Research Fellow Postdoctoral Fellow – Molecular Pharmacology of Feeding Behavior Join Dr. GPCR Ecosystem

GPCR University workshop on Advanced Data Analysis for GPCR Pharmacology, led by the esteemed Dr. GPCR Matchmaking Read Mark's job spotlight article for a Principal Scientist in In Vitro Pharmacology Mark recently discussed this exciting opportunity with Beth Fleck, Director of In Vitro Pharmacology World Congress of Basic and Clinical Pharmacology 2026 GPCR Jobs HIGHLIGHT Principal Scientist, In vitro pharmacology NEW Senior Scientist - Receptor Pharmacology NEW PostDoctoral Scientist Senior Research

Corner , our founder Yamina Berchiche works closely with organizations to help them navigate receptor pharmacology Push the boundaries  of receptor pharmacology and its real-world applications.   📚 Terry’s Corner — The Only On-Demand Pharmacology Hub with Dr. GPCR  community, you already know about Terry’s Corner  — our exclusive, on-demand pharmacology series where Terry Kenakin breaks down receptor pharmacology, functional selectivity, and ligand bias in a

and a research associate/scientist in in vitro pharmacology. GPCR Podcast : The Future of GPCR Drug Discovery with Molecular Modeling The field of GPCR research is “The best pharmacology teacher (Dr. Also super-valuable for those of us learning how to teach pharmacology” — Dr. GPCR scientists, translational pharmacologists, biotech drug discovery teams, and decision-makers who

This Week’s GPCR Intelligence: From Set-Point Pharmacology to No-Wash Internalization Assays This week signaling in metabolism, and future directions in biased ligand pharmacology. GPCR Podcast, the Revvity team built pHSense™ from the ground up by listening to what GPCR scientists GPCR scientists, translational pharmacologists, biotech discovery teams, and decision-makers who need GPCR innovation is accelerating.

That’s not a story about nostalgia — it’s a snapshot of how GPCR research was built, on technique at The Era of Cold Fingers and Patience Back then, GPCR signaling experiments weren’t elegant; they were The GPCR field needs thinkers who can direct platforms, not just operate them. What started as hand-built assays on ice has become integrated platforms for drug discovery, systems pharmacology GPCR Podcast 🔓 Get tools, deep dives, and exclusive insights with   Dr. GPCR Premium .

Binding Sites and Their Ligandability Potential Today, we started the Principles of Pharmacology II   Emerging Voices in GPCR Biology in Special Issue of Molecular Pharmacology GPCR Events, Meetings, and 2026 | 20th World Congress of Basic and Clinical Pharmacology GPCR Jobs Scientist I Cell Biology - Tectonic Therapeutic PhD fellowship in GPCR mechanosensing Senior Scientist, GPCR Pharmacology Research Associate - Professor Graeme Milligan Postdoc in Molecular Pharmacology - The Hauser Group Postdoctoral Scholar

Samuel Hoare on Advanced data analysis for GPCR pharmacology, which will be held on Thursdays between Pharmacology? , Mark Schmeizl, had a great conversation about this position with Beth Fleck, Director of In Vitro Pharmacology World Congress of Basic and Clinical Pharmacology 2026 GPCR Jobs NEW Post Doctoral Fellow Postdoc Position Principal Scientist, In vitro pharmacology Senior Associate Scientist - Global Research Technologies

Samuel Hoare on Advanced data analysis for GPCR pharmacology, which will be held on Thursdays between Vitro Pharmacology? , Mark Schmeizl, had a great conversation about this position with Beth Fleck, Director of In Vitro Pharmacology World Congress of Basic and Clinical Pharmacology 2026 GPCR Jobs NEW Postdoc Position Principal Scientist , In vitro pharmacology Senior Associate Scientist - Global Research Technologies Novo Nordisk Scientist

GPCR University We launched the Dr.GPCR University workshop on Advanced Data Analysis for GPCR Pharmacology And don’t miss our job opportunity spotlight for a Principal Scientist in In Vitro Pharmacology! in Neuroscience Novel pharmacological targets for GABAergic dysfunction in ADHD GPCRs in Oncology and World Congress of Basic and Clinical Pharmacology 2026 GPCR Jobs HIGHLIGHT Principal Scientist, In vitro pharmacology NEW Senior Research Associate/Associate Scientist, Protein Science NEW Post-Doctoral Fellow—Pharmacology

GPCR podcast is now available! Our guest is Mark Schmeizl! Listen where you get your podcasts https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/ #drgpcr #gpcr #podcast

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Gunnar Schulte, Lukas Grätz, Pawel Kozielewicz, et al. for their study on Frizzleds act as dynamic pharmacological Samuel Hoare on Advanced data analysis for GPCR pharmacology, which will be held on Thursdays between ): advances in structures, mechanisms, and drug discovery Frizzleds act as dynamic pharmacological entities Industry News Monash University retains its N° 2 global ranking for Pharmacy and Pharmacology Addex World Congress of Basic and Clinical Pharmacology 2026 GPCR Jobs NEW Principal Scientist, In vitro pharmacology

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GPCR courses GPCR Forum Initiate a vibrant conversation or seek assistance GPCR Events to keep you 12, 2024 | Pharmacology 2024 January 13 - 16, 2025 | PepTalk 2025 January 25 - 29, 2025 | SLAS 2025 | BIO International Convention 2025 July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology Chemistry PhD fellowship in GPCR mechanosensing Senior Scientist, GPCR Pharmacology Research Associate - Professor Graeme Milligan Postdoc in Molecular Pharmacology - The Hauser Group Postdoctoral Scholar

GPCR University course, 'Applying Pharmacology to Drug Discovery,' led by Dr. Pharmacological characterization and radiolabeling of VUF15485, a high-affinity small-molecule agonist Pharmacology: Unraveling the Secrets of Cellular Communication Bowes Biomedical Investigator Takes Aim , Meetings, and Webinars February 20, 2024 | Career Opportunities in Pharmacology and Drug Discovery World Congress of Basic and Clinical Pharmacology 2026 GPCR Jobs NEW Research Fellow NEW  Postdoctoral

GPCR research requires turning data into insights for drug discovery Hi GPCR Friends, Every week, critical motions of cell receptors; A Better Way to Treat Obesity; Unlocking the pharmacological potential of drug strategies shifting; antibody pharmacology opening fresh doors. GPCR Podcast – Ajay Yekkirala on GPCR Innovation In this episode, Dr. GPCR scientists, translational pharmacologists, biotech discovery teams, and decision-makers who need

August 2022 "GPCRs modulate a plethora of physiological processes and mediate the effects of one-third Read more at the source #DrGPCR #GPCR #IndustryNews

What emerged wasn’t just another pharmacology group — it became a collaborative engine for GPCR discovery Turning Silos into Systems The early 2000s were not kind to exploratory pharmacology. Why This Matters GPCR research demands integration — pharmacology, structural biology, signaling pathways GPCR science thrives in complexity — meaning no single lab or company can do it alone. GPCR Premium  for deep dives, strategic tools, and behind-the-scenes conversations shaping the GPCR field

Pharmacology & Therapeutics   2016 , 165 , 164–177. https://doi.org/10.1016/j.pharmthera.2016.06.007 European Journal of Pharmacology   2017 , 799 , 58–66. https://doi.org/10.1016/j.ejphar.2017.01.040 . European Journal of Pharmacology   2018 , 839 , 40–46. https://doi.org/10.1016/j.ejphar.2018.09.008 . Trends in Pharmacological Sciences   2018 , 39  (2), 187–199. https://doi.org/10.1016/j.tips.2017.10.004 Biochemical Pharmacology   1973 , 22 (23), 3099–3108. https://doi.org/10.1016/0006-2952(73)90196-2 .

Eric Trinquet, that moment arrived when his team successfully tracked GPCR internalization in native This innovation emerged from years of foundational work in photophysics and GPCR pharmacology. Just a plate reader, an agonist, and an endogenous GPCR. GPCR   Dr. GPCR X Revvity Collaboration ⸻ Want more like this? 👉 Join the Dr. GPCR Premium Ecosystem for behind-the-scenes access to GPCR innovators, exclusive deep-dives, and practical

Course Schedule and Details Every Thursday at 10 am EST Principles of Pharmacology in Drug Discovery Principles of Pharmacology in Drug Discovery II - Advanced Methods for the Optimization of Candidate , and more Class B1 GPCRs: Insights into Multi-Receptor Pharmacology for the Treatment of Metabolic Disease and Clinical Pharmacology 2026 GPCR Jobs NEW Postdoctoral Research Associate Senior Scientist - Discovery Director GPCR Drug Discovery Biologist Post-Doctoral Scientist- Molecular Pharmacology (FDE) Join Dr.

GPCR podcast is now available! Our guest is Dr. Adriano Marchese! Learn about his remarkable career and research in #GPCR signaling and trafficking. Listen where you get your podcasts https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/ #drgpcr #gpcr #podcast