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drivers or enablers of a given cancer through mutations located at cognate positions across GPCR paralogs opens

Meeting IRN I-GPCRNet (October 25 - 27, 2023) GPCR Retreat (November 2 - 4, 2023) Registration is now open

Johannes Broichhagen - aka JB  — which, amusingly, began when Hodson opened the door wearing cleaning

No one had their own lab. That meant no one could build a fiefdom — and everyone had to talk. leadership leveraged luck into durable structure  — through funding strategies, talent pipelines, and open

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“You start wide with chemistry, you narrow with biology, and at the end—if you did it right—you open

That opened the door to something rare in functional pharmacology: plate-based GPCR internalization tracking Trinquet tell the story in his own words?

Meeting IRN I-GPCRNet (October 25 - 27, 2023) GPCR Retreat (November 2 - 4, 2023) Registration is now open

Whether you’re in early discovery or clinical development, the strategies here could open doors in your own therapeutic area. 🧭  Join Us in Boston 🗓 Discovery on Target  — Boston, MA 📅 September 23-25,

spotlight; new tools tracking receptor motion; obesity drug strategies shifting; antibody pharmacology opening

It opened a new window into GPCR imaging in native tissue, and reshaped what this collaboration between

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That opened the door to a 2D sensor—one that responded cleanly to endosomal acidification with unmatched Trinquet tell the story in his own words?

It’s about how moments of redirection — even disappointment — can open new paths to impact.

Meeting IRN I-GPCRNet (October 25 - 27, 2023) GPCR Retreat (November 2 - 4, 2023) Registration is now open

know how to build the right partnerships and stay humble enough to let others’ strengths unlock their own It started with curiosity, openness, and the humility to admit that better answers required better tools

Open-source data: accessibility of databases to a wider audience will encourage the development of new Towards a comprehensive understanding of GPCRs, ligands, diseases, and their associations: open-access

Meeting IRN I-GPCRNet (October 25 - 27, 2023) GPCR Retreat (November 2 - 4, 2023) Registration is now open

Their physiological ligands are not fully understood, which opens new treatment possibilities.

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Career opportunities:  Explore a selection of high-level job openings in high-throughput screening, research

Early-bird registration for premium Ecosystem members opens on July 31st, so mark your calendars and

Registrations open on December 15th and close on February 1st to both Dr.

This dual role opens new possibilities for more complex and nuanced cellular responses.

. 👉 Opening with mechanisms forces the listener to do all the work. building for, why now is the right time, and how your solution fits into something bigger than your own

For discovery teams, this means a shorter exposure can yield longer efficacy windows—opening doors to can fail quietly at this stage —not because they’re weak, but because they’re too strong for their own Tissue Penetration Trap Here’s a paradox: high-affinity, slow-offset compounds can undermine their own Kenakin with your own enzyme or GPCR interaction puzzles.

However, over half of non-sensory GPCRs do not have drugs available in the clinic, opening the door to

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