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Binding affinity appears straightforward: add ligand, measure signal, fit a curve. Complex Two-Stage Biology Behind Orthosteric Binding GPCR pharmacology rarely follows the neat Langmuir adsorption receptor levels also deplete free tracer when tracer concentrations are low, breaking the assumption that added Non-specific binding control:  Adsorption to surfaces changes free ligand concentration. Terry Kenakin give scientists an uncommon advantage: the ability to interrogate foundational assumptions

pharmaceuticals and drug discovery, it is crucial for professionals to stay informed about the latest advancements We have 18 GPCR papers, four industry news articles, and two job ads. Connect with fellow scientists and dive into the latest in adhesion GPCR biology. in GPCR-targeted drug development in dermatology Advances in small-molecule insulin secretagogues for How To Discover Biologics For Challenging Targets Drug discovery, a biophysics perspective Bio-Rad Adds

In this edition, we have curated eight GPCR papers, five industry news, and two job ads. Samuel Hoare on Advanced data analysis for GPCR pharmacology, which will be held on Thursdays between Please complete this form to take advantage of this opportunity. Chemoattractant receptor signaling in humoral immunity Industry News Neurosterix launches with $63M to Advance Biologics US 2024 October 2 - 4, 2024 | 9th GPCRs in Medicinal Chemistry October 23 - 25, 2024 | 11th Adhesion

We have 15 GPCR papers, three industry news, and two job ads. Principles of Pharmacology in Drug Discovery II - Advanced Methods for the Optimization of Candidate October 3rd to 31st, 2024 Overview: Building on the basics covered in Course I, this course explores advanced GPCR Event Highlight 11th Adhesion GPCR Workshop Hosted by the Adhesion GPCR Consortium, this event will Join fellow scientists and researchers in person to stay updated with adhesion GPCR biology.

Additionally, GLP-1R couple to G protein-coupled receptor kinases (GRKs) and recruit β-arrestins, adding Moreover, exendin-P5 has been observed to reduce adipose tissue size more effectively than exendin, suggesting Indeed, incretin-based drugs like Novo Nordisk's Wegovy and Eli Lilly's Zepbound are advancing diabetes Anson, M., et al., Incidence of new onset type 2 diabetes in adults living with obesity treated with Rodriguez, P.J., et al., Semaglutide vs Tirzepatide for Weight Loss in Adults With Overweight or Obesity

Teams believe they can correct course by adjusting execution. This is not about adding more meetings or creating heavier processes.

We have 10 GPCR papers, five industry news, and one job ad. Let’s dive into the Classified GPCR News from March 11th to 17th, 2024 Adhesion GPCRs ADGRG1, an adhesion by a GPCR Industry News Domain Therapeutics and Chime Biologics announce manufacturing agreement  to advance Breakthrough in 3D Protein Structure Prediction of Large, Complex Protein Structures Newly discovered adhesion Biologics US 2024 October 2 - 4, 2024 | 9th GPCRs in Medicinal Chemistry October 23 - 25, 2024 | 11th Adhesion

We have 10 GPCR papers, six industry news, and two job ads. Additionally, if you participated in our Symposia in 2023, please take a moment to fill out this survey FENS Forum 2024 October 2 - 4, 2024 | 9th GPCRs in Medicinal Chemistry October 23 - 25, 2024 | 11th Adhesion

We have 15 GPCR papers, two industry news, and one job ad. congrats to: André Nguyen Dietzsch, Simone Prömel, et al. for their work on the Dysfunction of the adhesion GPCR latrophilin 1 (ADGRL1/LPHN1) increases the risk of obesity Norton Cheng, JoAnn Trejo, et al. for Please complete this form to take advantage of this opportunity on a first-come, first-served basis. the adhesion G protein-coupled receptor latrophilin 1 (ADGRL1/LPHN1) increases the risk of obesity GPCR

Additionally, we have six industry news. And if you're looking for a new job opportunity, we have one job ad. Please complete this form to take advantage of this opportunity on a first-come, first-served basis. Samuel Hoare on Advanced data analysis for GPCR pharmacology, which will be held on Thursdays between more Deorphanization of G Protein Coupled Receptors (GPCRs): a historical perspective Industry News Addex

We’ve curated 10 GPCR papers, seven industry news, and two GPCR job ads! This week's highlight: Dr. Kathleen M Caron and her team studied the GPER/GPR30 complex with β1-adrenergic receptor and AKAP5 in Let’s dive into the Classified GPCR News from January 8th to 14th, 2024 Adhesion GPCRs Conformational transitions and activation of the adhesion receptor CD97 GPCR Activation and Signaling Biased Signaling in Mutated Variants of β2-Adrenergic Receptor: Insights from Molecular Dynamics Simulations GPCRs in

our comprehensive GPCR coverage for the week; we have 14 GPCR papers, six industry news, and two job ads Additionally, if you participated in our Symposia in 2023, please take a moment to fill out this survey FENS Forum 2024 October 2 - 4, 2024 | 9th GPCRs in Medicinal Chemistry October 23 - 25, 2024 | 11th Adhesion

for this week, which includes 14 GPCR papers, four industry news, one GPCR Event, and two GPCR job ads Graham Ladds’ team refines AlphaFold models using binding calculations for human adenosine A3 receptor Due to popular demand, we have opened additional spots. If you'd like to join colleagues and Dr. Let’s dive into the Classified GPCR News from January 15th to 21st, 2024 Adhesion GPCRs The adhesion GPCR GPR116/ADGRF5 has a dual function in pancreatic islets regulating somatostatin release and islet

We have 15 GPCR papers, three industry news, one event, and one job ad. Samuel Hoare on Advanced data analysis for GPCR pharmacology, which will be held on Thursdays between Please complete this form to take advantage of this opportunity. Let’s dive into the Classified GPCR News from April 8th to 14th, 2024 Adhesion GPCRs High incidence of imperforate vagina in ADGRA3-deficient mice GPCR Activation and Signaling Local anesthetics inhibit

We have 19 GPCR papers, six industry news, two events, and two job ads. Additionally, we will be conducting a poster session in Zoom breakout rooms. Let’s dive into the Classified GPCR News from  February 19th to 25th, 2024 Adhesion GPCRs The Adhesion coupled receptor promotes the restoration of tension in epithelial cells GPCR Binders, Drugs, and more Advances Biologics US 2024 October 2 - 4, 2024 | 9th GPCRs in Medicinal Chemistry October 23 - 25, 2024 | 11th Adhesion

We have 21 GPCR papers, three industry news, and two job ads. Additionally, if you participated in our Symposia in 2023, please take a moment to fill out this survey Let’s dive into the Classified GPCR News from January 29th to February 4th, 2024 Adhesion GPCRs CELSR1 , a core planar cell polarity protein, features a weakly adhesive and flexible cadherin ectodomain GPCR toxin B and FZD7 Loss-of-function of GNAL dystonia gene impairs striatal dopamine receptors-mediated adenylyl

Tyrosine sulfation consists in the transfer of a sulfate group from the adenosine 3’-phosphate 5’-phosphosulfate Sulfo-glyco barcode - perspectives and added value in drug discovery A growing body of evidence proposes In addition, tyrosine sulfation is heterogenous between cell lines or even on the same cell (Scurci I

This pursuit in the best cases has remarkably led to groundbreaking technological advancements, such The authors emphasise the importance of understanding the advantages and limitations of different assay Advancements in G protein-coupled receptor biosensors to study GPCR-G protein coupling. Rößler P, Mayer D, Tsai CJ, Veprintsev DB, Schertler GFX, Gossert AD. Science advances. 2022;8(23):eabo4158. 53.         Carroll S.

Spurred on by new scientific and technological advances related to the understanding of structure and The engineered analog approach involves optimizing this scaffold, adding and subtracting molecular contacts Orion’s approach to engineering ligand analogs involves leaving the ‘address’ binding interface on the This characteristic provides a major advantage in drug discovery: massive parallel library-based screening Sci Adv, 7. https://doi.org/10.1126/sciadv.abg8685 · Structural explanation of the binding and

Built for growth means building a biotech team that can learn, adapt, and move forward together as the a few keep the company moving forward even when certainty is missing. 👉 They reframe the problem, adjust Do they freeze, escalate, or adapt? Survival-oriented candidates show adjustment, not frustration. 3️⃣ How they define responsibility: Pay They are the ones where individuals can decide, adapt, and move forward without waiting for perfect clarity

Even if the risk is manageable, not addressing it makes the fundraising process harder. other, fundraising conversations move faster and with less friction. ✅ For founders, this creates an advantage

When teams adopt structured decision cycles, consistent narrative checkpoints, and predictable timeline

Academic innovation moves discovery forward only when assays are validated, distributed, and adopted

The expert they admire is right there, but the fear of sounding unprepared wins. a Scientific Career Through Asking Better Questions in Science Late in the conversation, JB offers advice

But you do need a framework for identifying and addressing regulatory gaps early .

Furthermore, image-based data provide an additional check against off-target cytotoxicity or morphological Image-based validation adds interpretive power.   Visual displacement provides an additional confidence layer that traditional homogeneous binding assays

Premium: Sneak Peek Industry insights:  Lilly cuts Zepbound prices; Lilly hits $1T valuation; Novo advances Upcoming events:  Adhesion GPCR Workshop; GRC—Transporters, Ion Channels & GPCRs; MPGPCR Joint Satellite This is where system-level GPCR thinking  becomes a competitive advantage—long before a molecule reaches GPCR is a 501(c)(3) non-profit organization—your participation directly supports our mission to advance

If your pitch doesn’t address timing, portfolio alignment, or internal traction, the audience won’t do Instead of leading with technology, lead with the problem it addresses. ✅ Frame the situation in terms

The sections below synthesize the key topics addressed during the AMA and highlight the GPCR pharmacology Biased agonism introduces additional layers where one pathway may mimic “reflex-like” counterbalancing Kenakin  emphasized that the key advantage is not subtlety for its own sake—it’s bounded pharmacology For complex GPCR systems, this boundary is a strategic advantage: NAMs can only shift an agonist curve Kenakin  highlighted historical β-adrenergic cases where tachycardia appeared only once compounds reached

It started with curiosity, openness, and the humility to admit that better answers required better tools It fused them, creating a hybrid view of receptor signaling that has now been adopted by labs worldwide