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Our results show that a mutation in the K101 residue leads to loss in thermal stability of the serotonin1A We envision that our results could have potential implications in structural biological advancements

increased basal TrkB phosphorylation in the frontal cortex and hippocampus, which is in accordance with our Our data reveal the functional role of 5-HT2A–TrkB receptor heterodimerization and suggest that the regulated

Our results indicate that lateral diffusion parameters of serotonin1A receptors in normal cells are consistent Notably, our results show that statin-induced dynamic confinement could be reversed by destabilization

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August 2022 "We are happy to announce you our 2nd IRN i-GPCRnet meeting that will be held at the University

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In addition, our results suggest a previously unknown sodium-binding site located in the extracellular From our detailed characterization, we found particular interacting loci in the binding sites of the Our work will pave the way for understanding the CBD pharmacology at a molecular level and aid in harnessing

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Check out our GPCR roundup now, and be the first to read! This week's highlight: Congrats to our partner GPCR Therapeutics, on their expansion into fibrosis with

Based on our transcriptomic analysis, expression of GPER was correlated with clinicopathological variables Transcriptome-based bioinformatics analysis revealed that GPER was linked to pro-metastatic pathways in our

Although mature forms of PTHrP in the body consist of splice variants of 139, 141, and 173 amino acids, our Taken together, our results contribute to a better understanding of the biased signaling process of a

By using the Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) data, our analysis revealed Our analysis further supports the putative function of RGS proteins, particularly RGS20, in cancer."

Our results reveal that the extended N-terminus of the long isoform limits G protein activation yet elevates The pharmacological profiles and mechanistic insights of our study provide clues for the future design

Their applications have continually expanded our understanding of this important protein class.

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May 2022 "We are thrilled to announce that our co-founder Margaux Duchamp has been selected as a 30 under

In this sense, G protein-coupled receptors (GPCRs) may be a good option to try to prolong our life while Our compilation of data revealed that the mechanisms most involved in the role of GPCRs in lifespan are

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dimerization in class B1 GPCRs is an emerging area of research that has far-reaching implications for our This insight not only enhances our understanding of class B1 GPCR biology but also opens new avenues