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In this session, you’ll gain: Clarity on high-impact early safety assays and their compelling rationale innovation accelerate, timely guidance from foundational to advanced concepts has never been more urgent. 40 years of expertise at your fingertips: Explore the full library ➤ Or preview what’s inside: Read the latest articles ➤ 40 years of expertise at your fingertips : Explore the full library ➤

If you’ve felt the pace of GPCR research accelerating—and the signal getting harder to separate from the noise—you’re not alone. GPCR Premium Membership Gives You an Edge Dr. GPCR Ecosystem is entering its most ambitious phase yet. to step in. 👉   Email Us ➤ Yamina and the Dr.

And yet, momentum slowly fades. 👉 This is what makes biotech startup failure so difficult to recognize Each decision is rational in isolation, yet no one steps back to evaluate how those decisions interact Ready to Break Your Bottlenecks? Whether you're refining your narrative, making tough trade-offs, or simply feeling stuck, this session will help you get unstuck quickly. 👉 Book a 1:1 consult and start building the mindset your company

In This Session, You’ll Gain Clarity on how ADME governs translational success A deeper understanding Forty years of expertise, applied to modern discovery. Explore the full library Or preview what’s inside: Read the latest articles 40 years of expertise at your fingertips : Explore the full library ➤

It clarifies which problem you are solving first, which audience you are prioritizing, and which decisions your company wants to influence. Ready to Break Your Bottlenecks? Whether you're refining your narrative, making tough trade-offs, or simply feeling stuck, this session will help you get unstuck quickly. 👉 Book a 1:1 consult and start building the mindset your company

Yet early choices here determine speed, friction, and trust for the rest of the year. ✅ When these decisions you fix later. Ready to Break Your Bottlenecks? Whether you're refining your narrative, making tough trade-offs, or simply feeling stuck, this session will help you get unstuck quickly. 👉 Book a 1:1 consult and start building the mindset your company

They are full of capable people, yet progress slows. The issue is not ability. In early-stage biotech hiring, what matters is where you focus your attention . Ready to Break Your Bottlenecks? Whether you're refining your narrative, making tough tradeoffs, or simply feeling stuck, this session will get you unstuck — fast. 👉 Book a 1:1 consult and start building the mindset your company actually

Yet over time, alignment fades, and decisions start to feel disconnected. 👉 Many founders ask why biotech without changing direction 4️⃣ Roadmaps grow longer instead of sharper 5️⃣ Everyone is working hard, yet Ready to Break Your Bottlenecks? Whether you're refining your narrative, making tough tradeoffs, or simply feeling stuck, this session will get you unstuck — fast. 👉 Book a 1:1 consult and start building the mindset your company actually

Biotech fundraising has undergone a subtle yet significant shift. The science is strong, the patents exist, yet the IP does not clearly protect the company's commercial It is a signal of how well you understand your own company. Ready to Break Your Bottlenecks? Whether you're refining your narrative, making tough tradeoffs, or simply feeling stuck, this session will get you unstuck — fast. 👉 Book a 1:1 consult and start building the mindset your company actually

Yet small design choices—often treated as technical details—quietly reshape the affinity you think you Join before year-end to secure both. 👉   Join Terry's Corner Before Dec 31st, 2025 🎧 Dr. GPCR Year in Review: Carrying Better Experiments Into 2026 As 2025 closes, the Dr. This year brought 20+ podcast episodes, 40% audience growth, and an 811% increase in new listeners. translational strategy, Premium provides context that helps you act with confidence.

If you can’t articulate a trajectory, they categorize you as “interesting but unready.” 3️⃣ Internal without slides . ✅ If you can’t do that, you’re isolated. 2️⃣ Internal Decision Systems (Do decisions Your ability to connect it to investors, BD, the market, and your own team is the company. Ready to Break Your Bottlenecks? Whether you're refining your narrative, making tough tradeoffs, or simply feeling stuck, this session

Yet discovery teams routinely lose time and misallocate resources because the underlying biology behaves In practice: The IC 50 you measure is a function of tracer levels. As a member, you get: ✅ Full access to every course  — All 30 lessons released this year, plus new ones launching after the year-end break of expertise at your fingertips : Explore the full library ➤

It’s a masterclass in asking better questions in science, not as a skill you’re born with, but one you I’m running into a problem and I know you work on something similar — can I pick your brain for one minute You’re stating your purpose without hedging, signaling awareness of the other person’s expertise, and That first sentence is often the only barrier between you and the insight you need. Silence, by contrast, protects your ego but slows your research.

Yet curiosity and chemistry pulled him into the world of GLP-1R, pancreatic β-cells, and the biological questions David Hodson had been exploring for years. If this behind-the-scenes story resonated, you’ll love the full conversation.

Where’s your dose justification?   How consistent is your manufacturing?   can align your strategy to de-risk not just your data, but your decisions . If you can’t see them too, you’re not building strategy, you’re building surprises. If you wait for the FDA to point out what’s missing, you’re already behind. Because by the time they do, your timelines will stretch, your budgets will strain, and your confidence

assays—particularly membrane-based radioligand binding—often provide high-throughput measurements, yet In this article, you’ll learn:   How live-cell HCS provides physiologically relevant affinity measurements

moment was a cold email from a biologist he’d never met, asking if he could synthesize a molecule “when you That simple ask pulled a young chemist out of the fume hood and into the messy, electrifying world of Over the years, they learned from each other in ways that shifted both careers. If this behind-the-scenes story resonated, you’ll love the full conversation. 🎧 Listen to the full episode

If your work touches GPCR pharmacology, these insights aren’t optional—they’re essential. When you see the distortions baked into the system, you interpret your data differently and protect your What You’ll Learn Why peptide–fluorophore probes succeed where antibodies fail How parallel synthesis Don’t Fall Behind—Access the Edge You Need Already a Premium Member? Help us reach more scientists by providing quick rating on Spotify or Apple Podcasts — and a YouTube

In this session, you’ll gain: How system sensitivity transforms potency, efficacy, and agonist classification Why Terry’s Corner Give You The GPCR Pharmacology Insights You Need Terry’s Corner gives discovery scientists those who invest in deeper GPCR pharmacology insights today will shape tomorrow’s breakthroughs. 40 years of expertise at your fingertips: Explore the full library ➤

For years, the GPCR community wrestled with unreliable antibodies. For years, the data made no sense. The signaling didn’t line up. You need genetics teams for variant interpretation, metabolic phenotyping facilities for in vivo work It’s about trust — the kind of trust built when collaborators confirm your data, replicate your results , and call out your blind spots before reviewers do.

Yet, despite remarkable progress, HCS workflows remain vulnerable to several performance-limiting factors In this blog, you’ll learn:  How HCS works and why it is increasingly central to GPCR-based drug discovery

Sometimes the things you think are going to end up on the cutting-room floor become the best work. This solved a long-standing problem in GPCR biology: You can't understand signaling if you can’t see  We’re not here long enough to spend 30 years collaborating with people we don’t enjoy. For Early-Career Scientists Don’t optimize your trajectory for papers. Optimize it for questions that won’t leave you alone. Scientific progress is rarely linear.

You always need a scientific anchor — but you also need the courage to follow data where it leads. For real translational understanding, you need to see  the receptor in context. They start with people you actually like working with . don’t make sense yet. Sometimes the experiments you almost quit are the ones that matter most.

Yet, any pharmacologist who’s pushed beyond textbook theory knows: biology rarely plays fair. In this session, you’ll gain: A clear conceptual map of Schild analysis and its origins. In the full lecture, you will learn how to extract affinity even in this dual-behavior scenario: Focus Calcium flux assays, though tricky, yield valid Schild plots when analysis excludes non-equilibrium maxima Modern pharmacology has powerful modeling software, yet Schild analysis remains the litmus test for mechanism

  ✅  You don’t need to abandon your scientific instincts. But you do need to adapt them if you want your startup to scale .     Unless you update the way you lead, your startup will struggle to translate insight into impact.   Leadership isn’t in your lab notebook; it’s in how you decide     How to Know If You're Still Leading If you find yourself looping decisions or delegating them upward, you might be leaning on scientific

When you walk into a typical academic lab, the boundaries are obvious: this PI’s corner, that group’s The structure you train in often matters more than the experiment you start with. Monash team built rotational PhD cohorts  — students cycled through multiple groups in their first year Mini Timeline: How the Model Evolved Year 0  — Shared lab space established; PI buy-in secured Year 2   — Core imaging and signaling platforms launched Year 4  — Pooled grants fund expansion and training

Instead of a dozen wells, you could test hundreds. For Early-Career Scientists: Don’t over-invest in proving your pipetting skills. Like many, it was a mix of opportunity, timing, and the courage to say yes before everything was figured Technical mastery opened doors, but what kept her moving was knowing when to say yes before everything Mini Timeline: Manual assay years — technical rigor as foundation Technology boom — scaling curiosity

Yet that summer research placement cracked open a new reality: the thrill of asking questions no one For Early-Career Scientists: Your pivotal moment might not feel like fireworks. It might be quiet, subtle—an idea you can’t stop thinking about. Pay attention to that. But luck only works if you say yes when the door opens. For young scientists, that summer moment is waiting.

GPCR If the past few years were about rhythm, 2025 is about systems. Yamina’s open letter reflects on how Dr. Whether you’re designing the next assay, scouting a new therapeutic angle, or exploring career pivots , Premium helps you stay ready—without the noise. No matter where you are in your GPCR journey, Dr.

Yet, far less time is spent scrutinizing the structural logic and origin  of the molecules we screen In this lesson, you’ll gain: A strategic view of how chemical scaffolds shape pharmacologic outcomes Yet natural-product scaffolds come with costs: they are structurally complex, expensive to modify, often If natural scaffolds provided our starting pharmacology, what new scaffolds will define the next 50 years Those who learn now will shape the drugs others spend the next decade trying to understand. 40 years