Search Results

GPCR If the past few years were about rhythm, 2025 is about systems. Yamina’s open letter reflects on how Dr. Whether you’re designing the next assay, scouting a new therapeutic angle, or exploring career pivots , Premium helps you stay ready—without the noise. No matter where you are in your GPCR journey, Dr.

Yet, far less time is spent scrutinizing the structural logic and origin  of the molecules we screen In this lesson, you’ll gain: A strategic view of how chemical scaffolds shape pharmacologic outcomes Yet natural-product scaffolds come with costs: they are structurally complex, expensive to modify, often If natural scaffolds provided our starting pharmacology, what new scaffolds will define the next 50 years Those who learn now will shape the drugs others spend the next decade trying to understand. 40 years

Watch Episode 175 If your model can’t predict the future of GPCR drug discovery, why build it at all? Yet even with the structural biology revolution, one stubborn hurdle persists: prediction.   Yet functional selectivity, allosteric modulation, and biased agonism  remain major challenges. For scientists, this is an intellectual challenge: demand more from your models.  Are you demanding enough from yours? Want to go deeper into GPCR modeling? Dr.

Don’t miss out—secure your spot today! Registrations for the public will be on Monday! Hurry! Logo Contest : Let your creativity shine by submitting your design for the Logo Contest before August 15, 2024 Sponsorship Opportunities :   Elevate your brand's presence at this scientific event . Your participation is eagerly awaited!   Signaling: A Study of the Interplay Between Structure, Energy, and Function Engineering a GPCR-based yeast

A professor highlighted Carlsson’s talent in molecular modeling, a skill he hadn’t yet recognized as It wasn’t until his postdoctoral years at UCSF—under Brian Shoichet—that GPCRs entered his scientific First and foremost: follow the questions that keep you up at night. Finally, he advises young scientists to celebrate small wins. content you won’t find anywhere else. 🔬 Fuel your science. 🤝 Grow your network. 🚀 Lead the future

Kenakin from Terry's Corner shows how to tame irreversible drugs so their kinetic power works for you , not against you. Kenakin live and bring the questions that keep you thinking. Your Membership Gives You: Proven frameworks used in real discovery programs On-demand lessons built    💎  $2,999/year — the cost of one conference = a year of expert training — Premium Members Enjoy

Watch Episode 174 You never forget the day your data surprises you—in a positive way. For Dr. It’s a subtle yet powerful innovation. “You’re not changing the spectrum. Whether in industry or academia, whether overexpressing or not, you can adapt the assay to your system “You start wide with chemistry, you narrow with biology, and at the end—if you did it right—you open

Don’t just stay informed—immerse yourself, expand your knowledge, and become a trailblazer in the field Not a premium member yet?  No worries – you can sign up for a 5-day FREE trial! Adaptable Learning Access recorded sessions at your convenience to enhance your understanding. If you want to enhance your brand, email Hello@DrGPCR.com  for sponsorship opportunities. Get your 5-day free trial TODAY!

year of expert training Premium Dr. GPCR members save 50%+  with your Weekly News code. 👉  Join Terry’s Corner & Secure Your Spot for the Monthly AMAs  where you can challenge Dr. Kenakin with your own enzyme or GPCR interaction puzzles. If you’re not designing with persistent enzyme interactions in mind, you’re building risk into your molecule This session helps you get ahead of that curve. 🟢 40 years of expertise at your fingertips:   Explore

With the right tools, bold ideas, and powerful collaborations, you’re not just keeping pace. You’re actively shaping what’s next.

After 40+ years and 250 publications, Dr. The time you’ll save is yours. Terry’s Corner is coming soon. Dr. You can already explore the platform and subscribe to The Kenakin Brief—our new newsletter packed with sneak peeks, insights, and launch news straight to your inbox.   The time you’ll save is yours. Terry’s Corner is coming soon. Stay curious, The Dr. GPCR Team

If you’re building tools or careers in GPCR science, this is your playbook. “You can try, try, try—and fail, fail, fail,” Eric says. Frame your strategy, then let the serendipity occur.” — Dr. It also requires months—often years—of decisions, missteps, and refinements. a tool, starting a biotech, or running an academic lab—your mindset, not just your science, will determine

If you want your molecules to survive first contact with biology, enzyme inhibition must be part of your Your Membership Gives You: Proven frameworks used in real discovery programs On-demand lessons built a full year of expert training Unlock On-Demand Yearly Access Now — Premium Members Get Over 50% Discount Instead of chasing fragmented feeds, you get a single, credible source that respects your time and advances your work.

You’re not just designing for receptor activity—you’re designing for enzyme survival. year of expert training Premium Dr. GPCR members save 50%+  with your Weekly News code. 👉 Join Terry’s Corner & Secure Your Spot for the Monthly AMAs  where you can challenge Dr. Kenakin with your own enzyme or GPCR interaction puzzles. If you’re still treating metabolism as an afterthought, you’re designing risk into your pipeline. 🟢

The real question: are you letting your assay system dictate the wrong story? Short trailers give you a front-row seat before you commit. Here, you’ll get: Weekly lectures  that sharpen the exact tools you rely on in discovery. Monthly AMAs  where you can challenge Terry with your toughest questions. (and money) on the table. 🟢 40 years of expertise at your fingertips:   Explore the complete library

ask of your own data. Instead of treating binding as a binary event, Terry shows you how to interrogate whether your compound Recognizing how your ligand interacts with the receptor lets you predict safety margins, dose–response your toughest questions Direct input  on future topics, so the content tracks your team’s challenges 🟢 40 years of expertise at your fingertips:   Explore the complete library ➤ ✳️ Want to know what

Whether you’re optimizing screening campaigns or navigating translational challenges, these insights give you a sharper edge. Premium Members rely on this intelligence weekly—and here’s your curated preview. This week’s Terry’s Corner  exposes the unseen physiological “opponents” your molecule faces—and how Neither should you.

Yamina Berchiche, Founder of Dr. GPCR.

GPCR Drug Discovery at Discovery on Target 2025 — The Track You Can’t Miss If you work in drug discovery  or biotech , this is your moment. At Yamina's Corner , our founder Yamina Berchiche works closely with organizations to help them navigate can apply directly to your work. Whether you’re in early discovery or clinical development, the strategies here could open doors in your

If you’ve ever trusted a Ki value without asking how  it was measured, you’ve already stepped into the That’s your signal: kinetics are moving faster than your tools can measure. If you ignore it, you risk false certainty. Kinetics in Drug Discovery: Your Edge If you’re still treating potency as a static number, you’re missing And once you see it, you’ll never go back.

Hi GPCR Community, If you work on GPCR discovery, you already know: early signals can mislead, and timing your next decision is career-critical. Terry Kenakin to elevate your science and sharpen your decisions. GPCR Premium: Sneak Peek A fast, editorial preview—enough to guide your attention, not replace your due Bring the curve you’re debating. Ask. Challenge. Get an answer you can defend.

Ideal for live cell low cytometry, which means you can monitor while preserving cellular integrity. 3 In addition, we provide detailed protocols and expert guidance to help you achieve reliable, actionable

This week in Terry's Corner you'll learn how model-based thinking helps you determine a drug’s mechanism You don’t need more data—you need a way to translate snapshots into predictions. ’ve run your experiment. With a model, you don’t guess. You project. Think of models as your GPS—they don’t just explain where you are, they guide you to the next best turn

But for Ajay Yekkirala, that closed door lit the fuse for a career that would reimagine GPCR therapeutics But it was also a crucible: Ajay learned that science doesn’t matter if you can’t convince the world Advice for Young Scientists For early-career researchers, Ajay’s journey offers a powerful blueprint. Takeaway: Ajay Yekkirala’s story is not just about GPCR science or startup success.

GPCR Premium: Sneak Peek Your weekly edge — curated signals you won’t find on public feeds. Terry Kenakin walks you through which statistical tests actually answer the question you think you’re Power analysis tells you exactly how many replicates you need for 95% confidence. Validate with confidence:  Benchmark your results against literature standards and confirm whether your Bring the curve you’re debating. Ask. Challenge. Get an answer you can defend.

Celtarys, our GPCR fluorescent ligands are designed with a variety of photophysical properties to meet your

GPCR’s nonprofit mission to unite and empower the GPCR community worldwide FOMO is real: if you’re not in the room, you’ll be hearing about the connections you could have made. 2025 ⏰ Time:  6-8 pm EST 👥 Capacity:  Space is limited — early registration is recommended Secure Your Register Now 👉 Bring a colleague you trust . 👉 Don’t miss the chance to be part of the conversations

Watch Episode 172 What happens when the career you planned no longer feels right? “This wasn’t with much foresight for a couple years down the road. Your passion might not come first—it might come from doing the work. When you find something that excites you, it can transform your work into a source of joy and motivation It is essential to remain open to new experiences and to trust your instincts.

For Catherine, it became both—after years of uncertainty, pivots, and practical lab experience that grounded Like many young scientists, she explored different paths and gained industry experience before realizing seen a 30 to 60 percent increase in the number of fentanyl samples that contain xylazine in the past year

Sharpen your discovery decisions ➤ Yamina’s Corner - The Hidden Cost of Busy A GPCR program can collapse—not Stop wasting talent:  When senior leaders spend nights copy-pasting data, your burn rate accelerates Secure your seat today ➤ Why Dr. GPCR Premium Membership Gives You an Edge The GPCR field is advancing at breakneck speed. Premium Membership ensures you never miss it. 🚀 Join PremiumToday ➤