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In 2021, Bianca secured a permanent position as a lecturer.

validation in GPCR assay design Building reagents that must work in complex tissues, not just simplified models Her work centers on GPCR modulators, synthetic chemistry, and enabling robust biological assays through

GPCR Product Solutions Determine rank-order hits, evaluate ligand bias or allostery, study multiple targets

At Uppsala University, Jens Carlsson’s lab uses modeling to shape experiments—not just explain them. Home → Flash News → ep 175 with jens carlsson clip 2 If your model can’t change an experiment, what’s GPCR Podcast If your model can’t change an experiment, what’s the point? That’s the standard Dr. For him, modeling isn’t just about elegant simulations; it’s about impact . His team is clear about the capabilities and limitations of their models, an honesty that builds long-term

Home → Flash News → master gpcr pharmacologic models before its too late Published on July 11, 2025 Category They’re stalling because of slow decisions, misapplied models, and buried priorities. Terry’s Corner breaks down the 4 pharmacologic models that separate forecasting from guessing. Dr. ✳️ Read the Weekly News → https://www.ecosystem.drgpcr.com/post/crush-data-confusion-conquer-gpcr-drug-discovery

Marc Caron at Duke University for his post-doctoral training. In the Caron lab, Dr. Toronto and has continued working on dopamine transmission and homeostasis and the role of several of key modulators

Fellowship to develop novel methods of synthesizing 2-imidazoline scaffolds to be used as proteasome modulators

AI is transforming GPCR modeling. For decades, molecular modeling focused on explaining — rationalizing why a ligand binds, why a mutation With tools like AlphaFold , his lab can now model receptor–peptide complexes in seconds — an achievement A good model doesn’t just match published structures; it forecasts new biology, new ligands, and new insight reframes what “success” in computational pharmacology really means. 👉 Watch the full episode: model

downstream of the opioid receptors work, including the unique organization of chaperone protein Hsp90 modulation

Importantly, my work revealed heterogeneous spatial patterns of receptor density and activation, that are modulated

Committee Sponsors GPCR Retreat Program < Back to schedule Pharmacological and Genetic Preclinical Models

Home → Flash News → ep 175 with jens carlsson clip 1 Can your model actually predict the outcome of a Can your model actually predict the outcome of a GPCR experiment? At Uppsala University, Dr. Jens Carlsson and his team are redefining what computational modeling means in drug discovery. models have too often served as post hoc rationalizations. His team is candid about the limits of their models.

importance of choosing a city one would like to live in for several years when deciding on a postdoc position Additionally, they both agreed on the importance of mentorship in building confidence, with Yamina sharing her positive

Home → Flash News → ep 175 with jens carlsson release picture Model. Predict. But in the quiet hours, he found himself drawn to the structures, to the models, to figuring out why Professor of Computational Biochemistry at Uppsala University , where his lab uses structure-based modeling GPCR Podcast : https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/model-predict-discover #DrGPCR #GPCR

Organizations Elevate Scientific Offerings: Refine and optimize your GPCR assay platforms and in vitro models Differentiate Your Market Position: Showcase your specialized GPCR expertise to stand out from competitors

Dive into the logic of drug modeling with Terry Kenakin. In his latest lesson, he breaks down the essential models shaping modern pharmacology.

Jens Carlsson's take on predictive modeling. Jens Carlsson on predictive modeling—where structure-based design and MD guide experiments (and where If you’re advancing covalent or tight-binding candidates—or building models meant to predict, not narrate

identified the orphan CXCR7/ACKR3 receptor as being the 2nd receptor for CXCL12, which behaves as a modulator

During my Bachelor's in 2018, I sought practical lab experience and found a position as a student assistant

To test this, an LFS mouse model (germline Tp53 deletion) with a second floxed allele under the control Preliminary findings indicate that the simultaneous loss of Bai3 and Tp53 expression in our mouse model A mouse model of Zhu-Tokita-Takenouchi-Kim syndrome reveals indispensable SON functions in organ development He is also interested in working on Glioma Brain Organoid models." Hailey Steichen Abstract "Adhesion G protein-coupled receptors (aGPCRs) are important and understudied modulators

screens with state-of-the-art microscopy and high throughput screening to explain novel ways of GPCR modulation

in the journal Nature Communications (12 (1):4540, 2021) with the title "Gαq controls autophagy via modulation

Physiological and pathological roles of AGPCRs in the nervous system Beatriz Blanco Redondo · Willem Berend Post Approach (MS-BRET) Florian Seufert Unveiling the GPS Cleavage Mechanism in ADGRL1 with QM/MM Willem Berend Post Caroline Formstone Interrogating The Role Of CELSR1 (ADGRC1) In Breast Cancer Mariam Melkumyan GPR110 modulates TNIK Sumit Bandekar Structural studies of the CELSR1 extracellular region reveal a compact multidomain module regulates signaling Nicole Perry-Hauser Adhesion G protein-coupled receptor latrophilin-3 (ADGRL3) modulation

in Neuroscience from Ohio State University focusing on synaptic plasticity and adrenergic receptor modulation

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⚠️ What you’ll learn: ✅ Drug absorption, metabolism & clearance ✅ PK-PD modeling & therapeutic profiles ⚠️ What you’ll learn: ✅ Drug absorption, metabolism & clearance✅ PK-PD modeling & therapeutic profiles

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Her next career step took her to AstraZeneca as a postdoctoral trainee, where she studied animal models Andrew Charles that who specialized in animal models of migraine and delta-opioid receptors as a therapeutic