top of page

Search Results

Results found for "Dr. Thomas P. Sakmar"

  • 📰 GPCR Weekly News, December 11 to 17, 2023

    Dr. Save the date: February 8 - 29: Join Dr. GPCR University's live Zoom sessions hosted by Dr. Kenakin, according to his availability Access to the cohort’s Dr. GPCR Ecosystem group, where you can find Dr. Kenakin and Dr. GPCR Access to Dr.

  • Understanding Enzyme Inhibition In GPCR Discovery Programs

    . 🔍 This Week in Dr. 🎥 Live AMA with Dr. Kenakin — October 30, 12 PM EST Bring your toughest pharmacology questions and join Dr. 50% Discount at Checkout ➤ The Innovation Trap: Why Playing It Safe Can Kill Breakthroughs Revvity's Dr Read the roundup ➤ Why Dr.

  • Innovative Data-Driven Solutions: The pHSense Revolution

    For Dr. You’re just changing how bright it is—and how long it glows,” said Dr. Eric Trinquet. Listen to the full podcast episode here ⸻ More about Revvity pHSense Reagents GPCR Reagents Revvity on Dr GPCR   Dr. GPCR X Revvity Collaboration ⸻ Want more like this? 👉 Join the Dr.

  • 📰 GPCR Weekly News, May 13 to 19, 2024

    Dr. GPCR Podcast Exciting news! Episode 152 with Dr. Our most recent episode features our very own Dr. GPCR Board. Tune in and enjoy! Dr. Dr. GPCR Symposia Explore GPCRs with our Premium Membership! Access recorded material from previous events, including the Dr. GPCR Summit editions. In the meantime, visit Dr. GPCR Symposia and learn from experts in the field.

  • 📰 GPCR Weekly News, December 18 to 31, 2023

    This week's highlight: Drs. GPCR University's live Zoom sessions hosted by Dr. Terry Kenakin. Registrations are open to Dr. GPCR Ecosystem Members! GPCR Ecosystem group, where you can find Dr. Kenakin and Dr. GPCR Access to Dr.

  • 📰 GPCR Weekly News, September 11 to 17, 2023

    Dr. Congrats to Dr. GPCR Symposium on 'GPCRs as Therapeutic Modalities' with Richa Tyagi, Dr. Terry Kenakin, Dr. Oliver Hartley, Dr. Pierre Eftekhari, Dr. Lauren Slosky, Dr. Christel Menet, Dr. Ben Myers and Dr. Subscribe to the Dr. GPCR Newsletter and receive valuable insights!

  • How Advanced GPCR Kinetics Sharpen Decision Making (and Save You Time)

    That’s precisely what Terry’s Corner delivers each week: practical frameworks from Dr. SEP-631 for CSU; Maxion’s KnotBody® platform; a new angle on RGS protein modulation. 🔍 This Week in Dr Premium Members get a 50%+ discount when they join Terry’s Corner. 🚨 Live AMA with Dr. Register now and save with code SPK200 ➤ Why Dr. Access this week’s full Premium Edition here ➤ What our members say "Dr.

  • Mechanism vs. Assumption: A Model-First Path to Getting GPCR MoA Right

    That’s precisely what Terry’s Corner delivers every week: practical tools from Dr. Announces FDA Acceptance of sNDA for Setmelanotide in Acquired Hypothalamic Obesity. 🔍 This Week in Dr Premium Members get a 50%+ discount when they join Terry’s Corner. 🚨 First-ever Live AMA with Dr. This week, get to know Dr. Aaron McGrath from Takeda. He joins Dr. Register now and save with code SPK200 ➤ Why Dr.

  • A robust and Efficient FRET-Based Assay for Cannabinoid Receptor Ligands Discovery.

    .; Popov, P.; Benchama, O.; Zvonok, N.; Locke, K.; Qu, L.; Han, G. W.; Iyer, M. V.; Van Der Stelt, M.; Pacher, P.; Gertsch, J.; Ullmer, C.; McCormick, P. J.; Oddi, S.; Spaink, H. P.; Maccarrone, M.; Veprintsev, D. B.; Carreira, E. M.; Grether, U.; Nazaré, M. -P. -F.; Farce, A.; Chavatte, P.; Poupaert, J. H.; Lambert, D. M.; Depreux, P.; Hénichart, J.-P.

  • 📰 GPCR Weekly News, January 22 to 28, 2024

    Confirmed speakers include Drs. Dr. Dr. GPCR Volunteers Join our dynamic team as a volunteer! Dr. Dr. GPCR Members get 10% off with code MPDRGPCR10.

  • Glyco-sulfo hotspots in the chemokine receptor system

    2016) where O-glycosylation contributes to the differential binding to CC or CX3C chemokine (Casarosa P phosphosulfate (PAPS) donor to the hydroxyl group of a tyrosine residue of the protein chain (Seibert C and Sakmar sites in their N-termini that mediate ligand binding and signaling (Bannert N et al. 2001; Casarosa P glycosulfo peptide analogue GSnP-6 displays nanomolar affinity and promising potential for blocking PSGL-1/P-selectin

  • 📰 GPCR Weekly News, April 22 to 28, 2024

    We are pleased to announce five full scholarship opportunities for Dr. Join our upcoming Dr. GPCR University hands-on workshop with Dr.  The workshop includes: Four x 2-hour Zoom sessions One-on-one meeting with Dr. Hoare Access to Dr. GPCR Ecosystem group Access to course materials and recordings Completion certificate One-year Dr. Dr.

  • Navigating the Signaling Network: RTK and GPCR Crosstalk Uncovered

    phosphorylation of the G protein subunit Gαi at specific residues within three strategic hotspots: the P Key findings include: Phosphorylation Hotspots: P Loop (Ser44, Ser47, Thr48): Impairs ligand-stimulated Signaling Pathway Segregation: Phosphorylation events in the interdomain cleft and P loop uncouple G J., Ghassemian, M., Kufareva, I., & Ghosh, P. (2024).

  • From Ox Liver to AI: How the History of Pharmacology Shapes Its Future

    In this exclusive foundational-level lecture, Dr. Dr. Kenakin also celebrates the giants on whose shoulders we stand—A.J.

  • 📰 GPCR Weekly News, June 24 to 30, 2024

    This week's highlight includes congrats to: Drs. Bryan Roth and Brian Krumm for their study on Molecular glues as potential GPCR therapeutics Drs. work on G protein-coupled receptor endocytosis generates spatiotemporal bias in β-arrestin signaling Drs GPCR University We're thrilled to announce that Dr. Terry Kenakin will lead two brand-new, back-to-back courses tailored for the Dr.

  • 📰 GPCR Weekly News, January 29 to February 4, 2024

    Preston Nibley, Dr. Sudha K Shenoy et al. Dr. Xavier Leroy for his new role as CEO of GIO Therapeutics Dr. Confirmed speakers include Drs. Dr. Dr.

  • 📰 GPCR Weekly News, February 5 to 11, 2024

    This week's highlight includes congrats to: Drs. Confirmed speakers include DrsDr. Dr. Dr. GPCR Members get 10% off with code MPDRGPCR10.

  • 📰 GPCR Weekly News, March 11 to 17, 2024

    work on Direct interrogation of context-dependent GPCR activity with a universal biosensor platform Dr Dr. GPCR University Save the date for our upcoming workshop, starting May 9th, 2024, featuring Dr.  Under Dr. Hoare's expert guidance, you will gain invaluable skills in data analysis. Dr. Terry Kenakin's "Applying Pharmacology to Drug Discovery" course at Dr. Dr.

  • 📰 GPCR Weekly News, December 4 to 10, 2023

    This week's highlight: Dr. GPCR University live Zoom sessions hosted by Dr. Terry Kenakin. Registrations open on December 15th and close on February 1st to both Dr. The package includes four live Zoom sessions, a one-year Dr. Kenakin and Dr. GPCR.

  • Pharmacology at Your Fingertips: Terry’s Corner Launches

    Explore 10 on-demand lessons by Dr. Visit Yamina’s Corner Now CELT-335 - Celtarys Validates New Assay for CB1/CB2 Screening Dr. Stay curious,   The Dr. GPCR Team Join Our Newsletter!

  • Regulator of G Protein Signaling 20 Correlates with Long Intergenic Non-Coding RNA (lincRNAs)...

    clinical parameters such as alpha-fetoprotein and tumor grade in the HCC patients; (c) besides HCC (p was found to be an important factor for survival in four other cancers (clear renal cell carcinoma: p < 0.001, lung adenocarcinoma: p = 0.004, mesothelioma: p = 0.039, ovarian serous cystadenocarcinoma: p = 0.048); (d) RGS20 was found to be significantly associated with some tumor-related signaling pathways

  • Regulators of G-protein signaling: essential players in GPCR signaling

    Cell, 1997. 89(2): p. 251-61. https://pubmed.ncbi.nlm.nih.gov/9108480/ 2. Front Mol Neurosci, 2020. 13: p. 5. https://pubmed.ncbi.nlm.nih.gov/32038168/ 3. Cell, 2021. 184(4): p. 931-942.e18. https://pubmed.ncbi.nlm.nih.gov/33571431/ 6. J Neurosci, 2019. 39(42): p. 8291-8304. https://pubmed.ncbi.nlm.nih.gov/31308097/ 8. Genomics, 2021. 113(4): p. 2134-2144. https://pubmed.ncbi.nlm.nih.gov/33845140/

  • High GPER expression in triple-negative breast cancer is linked to pro-metastatic pathways and...

    of patients showed high GPER expression and significant correlation with the mRNA subtype of TNBC (P  = 0.001), total metastatic events (P = 0.019) and liver metastasis (P = 0.011). interval of 67.1 months, a significant trend towards reduced distant metastasis-free survival (DMFS) (P

  • 📰 GPCR Weekly News, July 31 to August 6, 2023

    This week's highlights: Dr. Randy Hall's study: GPR37L1's role in shaping cortical astrocytes during development Dr. The Dr. GPCR Symposium on 'GPCRs as Therapeutic Modalities' is set for September 22nd. Stay updated with the Dr. GPCR Newsletter for confirmed speaker announcements. Robert Lefkowitz Lab Postdoc Fellow - Dr.

  • Orthosteric vs Allosteric Interactions— and the pHSense Shift in Internalization

    Welcome to this week’s Dr. multiple transducers; plus obesity-drug program milestones and company pipeline updates. 🔍 This Week in Dr stay ahead of the science 🧠 Content built for biotech, pharma & academia 💬 Live monthly AMA with Dr Kenakin     💎 $2999/year — one conference cost = 12 months of expert training  Premium Dr. For Dr.

  • 📰 GPCR Weekly News, July 17 to July 23, 2023

    This week's highlighted papers: Dr. Dr. Mark your calendars for the upcoming Dr. Stay updated by subscribing to Dr. GPCR Newsletter! Robert Lefkowitz Lab NEW Postdoc Fellow - Dr.

  • Job Opportunity Spotlight #1: Principal Scientist, In Vitro Pharmacology

    Hello Dr. GPCR ecosystem members!  also the hiring manager for their open Principal Scientist, In Vitro Pharmacology role posted in the Dr By: Mark Schmeizl Chief Matchmaker at Dr. GPCR

  • 📰 GPCR Weekly News, July 24 to July 30, 2023

    Dr. Drs. Stay tuned by subscribing to the Dr. GPCR Newsletter! In case you missed it, recordings of the Dr. Robert Lefkowitz Lab Postdoc Fellow - Dr.

  • Predicting GPCR Function: Inside the Carlsson Lab’s Modeling Toolbox

    That’s the mission of Dr. Dr. . 🎧 Listen to the full episode of the Dr. GPCR Podcast Push the boundaries of what's possible 👉 Join the Dr.

bottom of page