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Why Purpose Matters in Science For some researchers, science is a job. For others, it’s a calling. That alignment between curiosity and urgency set her on the path toward doctoral research. What’s Next in Her Opioid Research Catherine’s current experiments focus on outcomes such as respiratory And GPCR pharmacology isn’t just an academic pursuit—it’s essential to understanding and responding to Catherine’s story shows that when purpose drives research, science becomes more than a job—it becomes

October 2022 Identification of A2BAR as a potential target in colorectal cancer using novel fluorescent GPCR ligands "G-protein coupled receptors (GPCRs) have been largely targeted in a wide range of diseases, but few therapies have been directed against GPCRs in the field of cancer, partly because of the lack Here, using colorectal cancer (CRC) as a model, we explored the gene expression of a panel of GPCRs in Read more at the source #DrGPCR #GPCR #IndustryNews

GPCR event of the year is the 3rd edition of the Summit. Come join us from October 10 to 16 to hear about exciting #GPCR research from amazing speakers. GPCR Ecosystem site member to attend the Summit, it’s free! ➡️ https://bit.ly/3SUkB8D #gpcr #drgpcr

September 2022 "Adhesion G protein-coupled receptors (aGPCRs) are cell-surface proteins with large extracellular Modulating a single function of a specific aGPCR isoform while affecting no other function and no other Here, we engineered an antibody, termed LK30, that binds to the extracellular region of the aGPCR ADGRL3 Our work provides proof of concept for the modulation of isoform- and ligand specific aGPCR functions therapeutics" Read more at the source #DrGPCR #GPCR #IndustryNews

His work spans deep academic research, startup life, and the application of machine learning and pharmacology to GPCR drug discovery. Superluminal Medicines: AI/ML Meets GPCR Pharmacology As Ajay continued to explore how GPCR signaling Advice for Young Scientists For early-career researchers, Ajay’s journey offers a powerful blueprint. He also underscores the value of developing cross-functional skills — including communication, strategy

We welcome suggestions, feedback, and announcements from the community. research? If I wanted to be part of the narrative, I felt that I had to join the community. And so I did. AB: The next workshop will likely bring together some of the hottest adhesion GPCR research going on Also, seeing the expanding diversity among the aGPCR community, added to the fact that this will all

GPCR signaling almost never follows a straight path. This article is about one big idea: GPCRs don’t act in isolation—they respond to the system they’re in In this session, you’ll gain: ✅ A mental model you can trust  for predicting how GPCR ligands behave Internalized Signaling: Same Receptor, Different Story A GPCR response isn’t always over when the receptor Constitutive Activity: When Doing Nothing Still Does Something Some GPCRs simply refuse to stay quiet

GPCRs have also been identified within the mitochondria. Compartmentalized GPCR Signaling from Intracellular Membranes. Insights into Nuclear G-Protein-Coupled Receptors as Therapeutic Targets in Non-Communicable Diseases Nature communications, 8(1), 443. https://doi.org/10.1038/s41467-017-00357-2 Jong, Y. Neurochemical research, 42(1), 166–172. https://doi.org/10.1007/s11064-016-2026-6 Mendizabal-Zubiaga,

October 2022 Regulation of pulmonary surfactant by the adhesion GPCR GPR116/ADGRF5 requires a tethered activation mechanism "The mechanistic details of the tethered agonist mode of activation for the adhesion GPCR Read more at the source #DrGPCR #GPCR #IndustryNews

GPCR Summit 2022 held between Oct. 10 - 16, it's FREE! Join the #GPCR movement by signing up now! ➡️ https://bit.ly/3cKMXlw #gpcr #drgpcr

Research Middle-Down Mass Spectrometry Reveals Activity-Modifying Phosphorylation Barcode in a Class 1A Receptor Microenvironment Industry News Addex and Indivior Extend Research Term Of Substance Use Papers GPCRs: Signal Transduction. GPCR Events, Meetings, and Webinars 2nd GPCR-Targeted Drug Discovery Summit | February 21-23, Boston. GPCR Ecosystem

But what are the conformation changes that drive GPCR dimerization? How dynamic are GPCRs dimer interfaces? GPCRs constantly bind to form dimers and dissociate to form monomers. But how can we target GPCR dimers? via%3Dihub #GPCR #DrGPCR#Ecosystem

GPCRs in Neuroscience Role of G-Proteins and GPCR-Mediated Signalling in Neuropathophysiology. Methods & Updates in GPCR Research Quantitation of Plasma Membrane (G Protein-Coupled) Receptor Trafficking Papers GPCRs: Signal Transduction. GPCR Events, Meetings, and Webinars 2nd GPCR-Targeted Drug Discovery Summit | February 21-23, Boston. GPCR Ecosystem

GPCR Activation and Signaling Molecular Mechanisms of PTH/PTHrP class B GPCR Signaling and Pharmacological Methods & Updates in GPCR Research 3,4-Bis(hydroxymethyl)hexane-1,6-diol-based Maltosides (HDMs) for Papers GPCRs: Signal Transduction. GPCR Events, Meetings, and Webinars 2nd GPCR-Targeted Drug Discovery Summit | February 21-23, Boston. GPCR Ecosystem

Hi GPCR Enthusiasts (and Arrestin Aficionados!)   This week at Dr. GPCR, we’re decoding arrestin-driven signaling and spotlighting the tools to match.   of GPCR-RAMP discovery. GPCR Updates   Advanced Methods for the Optimization of Candidate Selection  – Master GPCR behavior beyond Explore this week’s research, tools, and biotech insights in one place.

What if the way we've been studying GPCRs—arguably the most important drug targets in pharmacology—has Here’s the surprising truth: up to 80% of GPCR-targeted drugs fail—not because of poor chemistry, but Join Terry’s Corner and stay updated on the latest in GPCR research—delivered in a format that’s as approachable

GPCR Latrophilin1 in neurons. Autoimmune Skin Diseases: from Basic Research to Clinical Trials. Methods & Updates in GPCR Research CPGL: Prediction of Compound-Protein Interaction by Integrating Graph GPCR Signal Transduction. GPCR Ecosystem

GPCR Summit is totally FREE for our Ecosystem site members? ➡️ https://www.ecosystem.drgpcr.com/ #gpcr #drgpcr

We found that some agonist-induced GPCR/14-3-3 signal intensities can rapidly decrease. could also be paralleled with GPCR/β-arrestin-2 signals, indicating diminished levels of GPCR/signal Furthermore, we found that certain GPCR ligands can regulate GPCR/14-3-3 signals temporally, suggesting a new approach for GPCR drug development by modulating GPCR/14-3-3 signals temporally." Read more at the source #DrGPCR #GPCR #IndustryNews

In 2007 he formed IndiPharm which was a full-service Contract Research Organization whose operational #biotech #lifesciences #appointment #GPCR #Oncology" Read more at the source #DrGPCR #GPCR #IndustryNews

DrGPCR Ecosystem membership or listen wherever you get your podcast for free ➡️https://bit.ly/3UdxgnR #gpcr

G protein-coupled receptors (GPCRs) are a vast family of membrane-bound proteins crucial for transmitting 'unproductive coupling'[1] and a fascinating phenomenon known as GPCR priming [2]. The enhanced signalling observed in GPCR priming is attributed to the formation of temporal non-cognate-GPCR GPCR priming opens new avenues for understanding the nuanced regulatory mechanisms governing GPCR signalling In conclusion, GPCR priming represents a compelling area of research that promises to deepen our understanding

The cross-talk between growth factor receptors and GPCRs is an intriguing area of study. The primary research question addressed in this study was: How do growth factors, specifically through The researchers focused on the phosphorylation of the G protein subunit Gαi at specific residues within , leading to segregation of RTK-to-Gαi pathways from canonical GPCR-to-Gαi pathways. In conclusion, this research elucidates the molecular mechanisms by which growth factors influence G

Applications of Fluorescent Probes in Confocal Imaging of GPCRs: From Live to Fixed Cells GPCRs are present transmitting signals from the outside into the cells, making them an essential target in biomedical research PerkinElmer High Content Analysis System Operetta CLS used by a Celtarys Research coworker. Exploring the Applications of Confocal Fluorescence Microscopy in GPCR Research In GPCR research one Fluorescence Microscopy validation performed in the ONCOMET laboratory (Health Research Institute of

Biosensors for monitoring G protein-coupled receptors (GPCRs), the most drugged class of proteins in Read more at the source #DrGPCR #GPCR #IndustryNews Subscribe to the Newsletter HERE

the regulation of mTORC1 by upstream stimuli, with a specific focus on G-protein coupled receptor (GPCR

cooperative interaction between G βγ subunits and GIRK channels determines both the amplitude and kinetics of GPCR-dependent Read more at the source #DrGPCR #GPCR #IndustryNews

research papers and industry updates. Stay informed with the most recent developments in GPCR research and industry news. Justin English on "Empowering Drug Discovery for the GPCR Community"! Present Your Research: Submit your abstract by June 24th for priority consideration or by July 22nd for pharmacology Senior Scientist - Receptor Pharmacology Postdoctoral Scientist Senior Research Associate

This Thursday, explore the latest content on GPCRs, which includes 29 informative research papers and Stay informed about the most recent developments in GPCR research and industry updates. Rajagopal, Robert Lefkowitz, Howard Rockman for their review G Protein-Coupled Receptors: A Century of Research GPCR Ecosystem and our community. The classes will be online Thursdays from 10 am EST. pharmacology NEW Post-Doctoral Scientist- Molecular Pharmacology (FDE) NEW Research Assistant Senior

Watch Episode 170 Thinking Differently Pain research has long followed a familiar route: from molecule Why This Approach Matters In pain research, bottom-up approaches often fail to translate. This allows him to see how inflammation, cognition, and pain circuits overlap , and how GPCRs might serve And it challenges the GPCR community to use its tools not just to explain, but to intervene. ___ Keyword Cloud: GPCR podcast , pain modeling , GPCR online course , translational research , neuroimmune