These studies also show that disrupting the dimerization of GLP-1R results in decreased high-affinity extracellular domain (ECD), facilitating the partial disengagement of the peptide while maintaining high-potency

She found herself drawn toward the science behind the drugs, rather than their clinical application.

produce robust effects on behavior across species, and recent research has benefited from advances in high-resolution

GPCR mutations in cancer   show both driver-like patterns and high redundancy, prompting a call for multiomics

Steyaert bridged fundamental high-impact research in biomedical sciences with the mechanistic understanding

At high cholesterol concentrations, LYCHOS bound to the GATOR1 complex, a guanosine triphosphatase (GTPase

New high-resolution structures of CB1 receptor in different functional states have significantly improved

Interestingly, there were also significant differences in receptor degradation, with S339fs5 having a very high promotes enhanced signaling, reduced phosphorylation, β-arrestin binding and endocytosis, and a very high

HLGR2 is a typical GPCR and shows high structural and sequence similarity with other insect LGR2 proteins rate (45.00%), body malformation, abnormal wing expansion, failed cuticle melanization (63.33%), and high

To exert their functions requiring high sensibility and specificity, T cells need to integrate different

structure models in the functional study and structure-based drug design of GPCRs, which required reliable high-resolution

follows this logic, it respects the listener’s time, builds trust fast, and moves the conversation toward

disciplines collaborate effectively, pharmacology data becomes a roadmap that guides molecular design toward

ligand, enabling cell-free as well as cellular NanoBRET-based binding studies in a non-isotopic and high-throughput

Thus, we need to know much more about the structures of receptor-ligand complexes at high resolution.

meningitidis is a Gram-negative opportunistic pathogen that is responsible for causing human diseases with high

Data Dilemma: The Lego Bucket Problem I've seen promising GPCR programs generate massive volumes of high-quality

state; three-dimensional (3D) cell models, or organoid models, that assist with target identification, high-throughput

Despite its high mechanistic complexity, the modularized QSP platform can be readily reproduced, expanded

, GPCRs, and more Lessons from the physiological role of guanosine in neurodegeneration and cancer: Toward

protein complexes and solute carriers, are relevant to immunology indications and rare diseases with high

Propranolol, initially prescribed for high blood pressure, irregular heart rate, essential tremor, and

Despite this high number of GPCR targeted drugs, only a small portion (∼110) of the human GPCRome (consisting

Hence, the H3R conformational biosensor in membranes might be a ready-to-use, high-throughput alternative

effective at monitoring real-time A2BAR receptor labeling using live-imaging modalities, and displayed high

fragment- and lead-like chemical libraries have complementary advantages and illustrate how access to high-resolution

diseases, (d) showed spontaneously fluctuating Ca levels from approximately normal to near fatally high

Pharma interest is high, as reflected in major deals across the space.

Louis-Jeantet Foundation and the 2022 Benjamin Franklin Medal in Chemistry from The Franklin Institute "Huge

recombinant protein production expertise, across mammalian, insect, and bacterial expression systems with high-resolution