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We aim to make education accessible to all! behavior in important human cell regulator, opening up a new drug target for cancer, other diseases Call

and Pharmacology Addex Therapeutics to Release Full-Year 2023 Financial Results and Host Conference Call

development DeepCure team is excited to welcome Justin Potnick, to our Medicinal Chemistry group Call

Chinese hamster ovary-K1 cells and its use in the G-protein-coupled receptor assays Predicting the Hallucinogenic

phase I clinical study in patients with advanced, recurrent or metastatic solid tumors: the EPRAD study Call

These early decisions usually fall into a few recurring categories: 1️⃣ What does the team truly focus When they are made implicitly, or not at all, teams spend the rest of the year reacting. ✅ Execution

We’re committed to making education accessible to all! Adiso Announces Groundbreaking Research Highlighting ADS024 a Novel Oral Agent for Neuroinflammation Call

Why Traditional Radioligand Methods Fall Short for Modern Screening Needs Radioligand binding assays

Discovery Upstream Bio Announces the Appointment of Marcella Ruddy, M.D., to the Board of Directors Call

This week, we would like to highlight two new publications: Pharmacological hallmarks of allostery at Structural and Molecular Insights into GPCR Function Pharmacological hallmarks of allostery at the M4

Roughly half of the receptors in the superfamily are sensory GPCRs, involved in olfaction, taste, vision As seen below in Figure 1, natural ligands do not make use of all the potential binding contacts with The unmodified ‘address’ interaction ensures that all molecules in the library are specific for the target receptor rather than irrelevant cell surface targets, meaning that in contrast to all of the other current flow-based human monocyte endothelial transmigration assay, OB-004 strongly outperformed BMS813160 at all

Thomas, Smith, O’Boyle, de Graaf & Bender, 2021) and 4) limit of input data can lead to a phenomenon called

A hallmark of aGPCR activation is the removal of the inhibitory GAIN domain and the dipping of the cleaved

Mrgpra2 were critical for combating S. aureus infections and the formation of neutrophil abscesses, a hallmark

psychedelic drug actions and suggest that these discoveries can facilitate new insights into their hallucinogenic

inflammation linked to autophagy deficiency in myeloid cells "Background Eosinophilic inflammation is a hallmark

smaller set of G proteins, arrestins, and effectors, activate downstream pathways that often modulate hallmark

We report that arrestin-3 modulates Fgr activity with a hallmark bell-shaped concentration-dependence