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This week, we would like to highlight two new publications: Pharmacological hallmarks of allostery at Structural and Molecular Insights into GPCR Function Pharmacological hallmarks of allostery at the M4

Roughly half of the receptors in the superfamily are sensory GPCRs, involved in olfaction, taste, vision As seen below in Figure 1, natural ligands do not make use of all the potential binding contacts with The unmodified ‘address’ interaction ensures that all molecules in the library are specific for the target receptor rather than irrelevant cell surface targets, meaning that in contrast to all of the other current flow-based human monocyte endothelial transmigration assay, OB-004 strongly outperformed BMS813160 at all

Thomas, Smith, O’Boyle, de Graaf & Bender, 2021) and 4) limit of input data can lead to a phenomenon called

A hallmark of aGPCR activation is the removal of the inhibitory GAIN domain and the dipping of the cleaved

Mrgpra2 were critical for combating S. aureus infections and the formation of neutrophil abscesses, a hallmark

psychedelic drug actions and suggest that these discoveries can facilitate new insights into their hallucinogenic

inflammation linked to autophagy deficiency in myeloid cells "Background Eosinophilic inflammation is a hallmark

smaller set of G proteins, arrestins, and effectors, activate downstream pathways that often modulate hallmark

We report that arrestin-3 modulates Fgr activity with a hallmark bell-shaped concentration-dependence