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His research interest lies in understanding the molecular basis for human tumor development and how to Van Meir has developed novel therapeutic approaches for cancer using oncolytic adenoviruses and anti-angiogenic molecules and is currently developing novel small molecule inhibitors of the hypoxia-inducible factor His research aims to translate these novel agents to testing in clinical trials with the hope to develop the future, we plan to decipher the roles of N-glycosylation of ADGRG6 in organogenesis and tissue development

Ben’s research focuses on Smoothened and other class F GPCRs which play essential roles in embryonic development within the primary cilium, a tiny antenna-shaped structure at the cell surface with critical links to development Ben studied developmental and cancer signaling as a postdoctoral fellow with Philip Beachy at Stanford

My project involved the development of FRET/BRET -based GPCR conformational biosensors, which can be I spent 2 1/2 years in his lab and developed novel conformational sensors for these intriguing receptors

identification of small molecule regulators of these proteins, and progressing such ligands in drug development non-alcoholic steatohepatitis (NASH) and inflammatory diseases and Keltic Pharma Therapeutics (2020) which is developing

She developed expertise over the past two decades studying structure/function relationships of GPCRs the fundamental knowledge of GPCR biology and for the identification of drug targets and future drug development Manager, where they managed a technical support team providing scientific data analysis and database development contributed analytic support resulting in authorship of numerous scientific publications and new funding, and developed delivered technical presentations and software demonstrations to prospective customers worldwide, and developed

Dr Stagg has served as an expert consultant in the development of adenosine-targeting drugs, several permanent member of the Scientific Advisory Board (SAB) of Surface Oncology, a clinical stage company developing

This conversation is especially valuable for scientists developing functional assays, fluorescence-based lab structure at Monash Institute of Pharmaceutical Sciences fosters innovation in functional assay development Get behind-the-scenes conversations, advanced assay development strategies, and practical GPCR tools

consultancy and data analysis company supporting pharmaceutical, life science, and academic scientists in the development He specializes in kinetic analysis of drug action and is known for applying binding kinetics to the development

In 2005 he started working on the development of conformational thermostabilization of GPCRs, which resulted In 2016 mini-G proteins were developed as a tool for the structure determination of GPCRs in the fully

He is the Research director at INSERM with a specific interest in G protein-coupled receptors by developing loss-of-function variants of the MT2 melatonin receptors that are associated with type 2 diabetes (TD2) development

He has focussed on developing a comprehensive map of ovarian cancer essential genes using whole genome Several of these targets are being developed for potential new therapeutic strategies in ovarian and

Broichhagen reveals how fluorescent probes transform GPCR imaging, internalization studies, and assay development Balanced creativity in tool development with the pressure for reproducible, publication-grade data. research group at the Leibniz Research Institute for Molecular Pharmacology (FMP) in Berlin, focusing on developing

Bridge theory to practical drug development decisions?

To address this, we developed the NTF release sensor (NRS), a genetically encoded reporter that facilitates latrophilin-type aGPCR Cirl/ADGRL in Drosophila, revealing NTF release and receptor dissociation within the developing In addition, the platform was used to develop assays for high-throughput screening for challenging adhesion research aims to leverage this knowledge to identify novel pharmacological targets and contribute to the development

receptor 110 (ADGRF1, GPR110), an adhesion GPCR recently deorphanized, plays an important role in in the development activation promotes neurogenic differentiation of neural stem cells, neurite growth, and synaptogenesis of developing Regulates Mating In The Closest Relatives Of Animals Alain Garcia De Las Bayonas Abstract "All animals develop

pharmacological chaperones, his work on bioluminescence resonance energy transfer (BRET) resulted in the development a member of the lab, I am humbled to have been able to work with him and his team and use the tools developed

Robert Laprairie is an Associate Professor and the Saskatchewan Research Chair in Drug Discovery and Development

He has more than 20 years of experience in GPCR, primarily focused on drug discovery and developing new

nervous system disorders realm to understand the neurobiology of neuropsychiatric disorders and to develop

properties of these new ligands are deemed exceptional, a lead optimization is realized and its therapeutic development

Robert Laprairie is an Associate Professor and the Saskatchewan Research Chair in Drug Discovery and Development

A large component of his work is centered around dysregulated signaling in cancer and the development

His lab focuses on developing and innovating technologies to solve broad questions in pharmacology, with

information on dysregulated signaling circuitries and individual genomic and molecular alterations to develop

medicinal chemist in Italy, followed by a Ph.D. in computational medicinal chemistry, during which she developed

We have developed an array of fluorescent biosensors to map kinase activity in living cells and are exploring

(MFI): a reliable, self-sustaining computational chemistry service provider, developing its own software

Alice Ting developing programmable receptors for molecular sensing and controlling cellular behaviour

His current work is mainly focused on screening and assay development to bridge the gap between in vitro

Get it wrong, and the best molecule on paper stalls in development.