Search Results

Dr Stagg has served as an expert consultant in the development of adenosine-targeting drugs, several permanent member of the Scientific Advisory Board (SAB) of Surface Oncology, a clinical stage company developing

This conversation is especially valuable for scientists developing functional assays, fluorescence-based lab structure at Monash Institute of Pharmaceutical Sciences fosters innovation in functional assay development Get behind-the-scenes conversations, advanced assay development strategies, and practical GPCR tools

consultancy and data analysis company supporting pharmaceutical, life science, and academic scientists in the development He specializes in kinetic analysis of drug action and is known for applying binding kinetics to the development

He has focussed on developing a comprehensive map of ovarian cancer essential genes using whole genome Several of these targets are being developed for potential new therapeutic strategies in ovarian and

He is the Research director at INSERM with a specific interest in G protein-coupled receptors by developing loss-of-function variants of the MT2 melatonin receptors that are associated with type 2 diabetes (TD2) development

In 2005 he started working on the development of conformational thermostabilization of GPCRs, which resulted In 2016 mini-G proteins were developed as a tool for the structure determination of GPCRs in the fully

Bridge theory to practical drug development decisions?

To address this, we developed the NTF release sensor (NRS), a genetically encoded reporter that facilitates latrophilin-type aGPCR Cirl/ADGRL in Drosophila, revealing NTF release and receptor dissociation within the developing In addition, the platform was used to develop assays for high-throughput screening for challenging adhesion research aims to leverage this knowledge to identify novel pharmacological targets and contribute to the development

pharmacological chaperones, his work on bioluminescence resonance energy transfer (BRET) resulted in the development a member of the lab, I am humbled to have been able to work with him and his team and use the tools developed

receptor 110 (ADGRF1, GPR110), an adhesion GPCR recently deorphanized, plays an important role in in the development activation promotes neurogenic differentiation of neural stem cells, neurite growth, and synaptogenesis of developing Regulates Mating In The Closest Relatives Of Animals Alain Garcia De Las Bayonas Abstract "All animals develop

He has more than 20 years of experience in GPCR, primarily focused on drug discovery and developing new

Robert Laprairie is an Associate Professor and the Saskatchewan Research Chair in Drug Discovery and Development

properties of these new ligands are deemed exceptional, a lead optimization is realized and its therapeutic development

Robert Laprairie is an Associate Professor and the Saskatchewan Research Chair in Drug Discovery and Development

nervous system disorders realm to understand the neurobiology of neuropsychiatric disorders and to develop

His lab focuses on developing and innovating technologies to solve broad questions in pharmacology, with

information on dysregulated signaling circuitries and individual genomic and molecular alterations to develop

A large component of his work is centered around dysregulated signaling in cancer and the development

Get it wrong, and the best molecule on paper stalls in development.

medicinal chemist in Italy, followed by a Ph.D. in computational medicinal chemistry, during which she developed

(MFI): a reliable, self-sustaining computational chemistry service provider, developing its own software

His current work is mainly focused on screening and assay development to bridge the gap between in vitro

We have developed an array of fluorescent biosensors to map kinase activity in living cells and are exploring

She developed expertise over the past two decades studying structure/function relationships of GPCRs

He has developed innovative methods for in-cellulo measurement of protein-protein interactions, receptor

She is an internationally recognized biophysicist for her contributions in developing constrained molecular

He has developed novel tools and methodologies to study fungal GPCRs which allowed the determination

Aaron has a proven track record as a biologics leader as he led teams to discover and develop novel first-in-class

Brian has contributed to the discovery or development of 5 marketed drugs through his work spanning molecular

The ultimate goal of Adriano’s research is to target novel aspects of GPCR signaling for therapeutic development