Search Results

June 2022 "G protein-coupled receptors (GPCRs) represent a major therapeutic target class as they play GPCRs are divided into six classes based on amino acid sequence similarities, but only four of the classes GPCRs respond to a wide variety of signals that range in size from photons to proteins (Foord et al., In 2019, 5 out of 20 first-in-class approved therapeutic agents targeted GPCRs. Read more at the source #DrGPCR #GPCR #IndustryNews

GPCR University We are thrilled to announce that Dr. GPCR Podcast Tune into the 156th episode of the Dr. GPCR Podcast, featuring Dr. GPCR Consortium: The 11th Adhesion GPCR Workshop. Events, Meetings, and Webinars June 9 - 14, 2024 | 2024 Phosphorylation and G-Protein Mediated Signaling GPCR Ecosystem

Our most recent episode features our very own Dr. GPCR Board. Tune in and enjoy! Dr. GPCR Symposia Explore GPCRs with our Premium Membership! Events, Meetings, and Webinars May 27 - 29, 2024 | SLAS Europe 2024 Conference and Exhibition June 2 - 7, 2024 | Chemotactic Cytokines NEW June 4, 2024 | Live Webinar ‘It All Starts With a Protein – Protein GPCR Ecosystem

September 2022 GPCR/endocytosis/ERK signaling/S2R is involved in the regulation of the internalization and -activating properties of human salivary histatin 1 "Human salivary histatin 1 (Hst1) exhibits a series We investigated the influence of specific inhibitors of G protein-coupled receptors (GPCR), endocytosis The inhibitors of GPCR, ERK1/2, phagocytosis, and clathrin-mediated endocytosis (CME) as well as siRNA Read more at the source #DrGPCR #GPCR #IndustryNews

Applications of Fluorescent Probes in Confocal Imaging of GPCRs: From Live to Fixed Cells GPCRs are present How Fluorescent Probes Enable High-Resolution Confocal Imaging of GPCRs To study the dynamics of GPCRs In this strategy the GPCR is modified genetically to fuse an engineered enzyme. Exploring the Applications of Confocal Fluorescence Microscopy in GPCR Research In GPCR research one Microscopy and spectroscopy approaches to study GPCR structure and function.

August 2022 GPCRs steer G i and G s selectivity via TM5-TM6 switches as revealed by structures of serotonin The structural basis for G protein subtype selectivity by these GPCRs remains elusive. We find that the macro-switch by the TM5-TM6 length is shared by class A GPCR-G protein structures. results present a common mechanism of Gs versus Gi protein coupling selectivity or promiscuity by class A GPCRs Read more at the source #DrGPCR #GPCR #IndustryNews

GPCR Summit 2022 is less than a month away! Come live and breathe GPCRs with us and don’t forget to submit your abstract. ➡️https://bit.ly/3Q7hlnT #gpcr #drgpcr

has been on the rise in biotech in recent years as researchers have discovered the vast potential for GPCR-targeting to that star are Verily and Sosei Heptares, which have struck a research agreement to discover new GPCR financial details of the strategic collaboration weren’t released, but Sosei Heptares’ past two team-ups in GPCR-based Read more at the source #DrGPCR #GPCR #IndustryNews

Hi GPCR Fanatics,   This week’s insights will help you avoid wasted time, poor forecasts, and stalled 🔹 Elevate your strategy → Building clarity in GPCR drug discovery Even the strongest GPCR programs GPCR University Learner Dr. GPCR Podcast - Surviving Discovery’s Gauntlet Dr. Listen Now – Real Lessons from a GPCR Expert ➤ The future of GPCR isn’t waiting. GPCR Team Read Full Edition ➤

GPCR Summit. GPCR in-person event. Announces $103 Million Series A Financing Co-Led by MPM BioImpact and Novo Holdings Neurocrine Biosciences Events, Meetings, and Webinars May 13 - 17, 2024 | 20th Annual PEGS Boston Summit May 16 - 19, 2024 GPCR Ecosystem

Please complete this form to take advantage of this opportunity on a first-come, first-served basis. GPCR Symposia Join us on June 7th for our symposium on Structural and Molecular Insights into GPCR Function Let’s dive into the Classified GPCR News from April 15th to 21st, 2024 GPCR Activation and Signaling Events, Meetings, and Webinars April 17 – May 1, 2024 | FREE ASPET Virtual Award Lecture Series May GPCR Ecosystem

This makes it an ideal candidate for GPCR research, where accuracy in detecting subtle signaling changes Enhancing HTRF Assay Performance in GPCR Research Using Fluorescent Ligands GPCRs are involved in numerous GPCRs are not always the most numerous in cells. This has been done in assays tracking IP1 and cAMP to detect biased agonism in GPCR ligands Table 1. ligands offer both high affinity and exceptional selectivity across a wide range of GPCR targets.

Hey there, GPCR Enthusiasts! Ready for your GPCR quest, so bold and bright? GPCR Event Spotlight 11th Adhesion GPCR Workshop    📍  Mexico City 📅 October 23 - 25, 2024 Get ready to party with GPCRs next week! Emerging Voices in GPCR Biology in Special Issue of Molecular Pharmacology GPCR Events, Meetings, and Webinars October 17, 2024 | Unprecedented fragment-based screening using Spectral Shift for GPCRs October

Check out our GPCR coverage for this week. It's on a first-come, first-served basis. GPCR Partnered Events April 22 - 23, 2024 | Endocrine Metabolic GPCRs Join the Endocrine Metabolic GPCRs Events, Meetings, and Webinars NEW April 17 – May 1, 2024 | FREE ASPET Virtual Award Lecture Series GPCR Ecosystem

Check out our GPCR coverage for this week. Please complete this form to take advantage of this opportunity on a first-come, first-served basis. Let’s dive into the Classified GPCR News from April 22nd to 28th, 2024 Adhesion GPCRs Dysfunction of Events, Meetings, and Webinars May 13 - 17, 2024 | 20th Annual PEGS Boston Summit May 16 - 19, 2024 GPCR Ecosystem

It's on a first-come, first-served basis. GPCR Symposiums and much more! GPCR Partnered Events April 22 - 23, 2024 | Endocrine Metabolic GPCRs Join the Endocrine Metabolic GPCRs Events, Meetings, and Webinars May 13 - 17, 2024 | 20th Annual PEGS Boston Summit May 16 - 19, 2024 GPCR Ecosystem

Check out our GPCR coverage for this week. We have 15 GPCR papers and four industry news. GPCR Symposium on GPCR activation and signaling sessions. GPCR Partnered Events April 22 - 23, 2024 | Endocrine Metabolic GPCRs Join the Endocrine Metabolic GPCRs Events, Meetings, and Webinars March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference GPCR Ecosystem

Tom Sakmar didn’t set out to map GPCR-RAMP interactions across hundreds of receptors. , multiplexed platform to investigate GPCR-RAMP biology  like never before. and an online platform to query GPCR-RAMP interaction data and antibody validations. interactions , Family B GPCRs , GPCR scientist network , GPCR data platform , Dr. GPCR ecosystem

GPCR Podcast, we have Dr. Pina Cardarelli, CSO of GPCR Therapeutics. ecosystem.drgpcr.com/dr-gpcr-podcast/ #gpcr#drgpcr #podcast

October 2022 "G protein-coupled receptors (GPCRs) play critical roles in human physiology and are one endogenous ligands (orthosteric site), allosteric modulators offer new avenues for the regulation of GPCR Recent advances in the structure determination of GPCRs bound to different types of allosteric modulators In this review, we provide a systematic analysis of the currently available GPCR structures in complex Read more at the source #DrGPCR #GPCR #IndustryNews

Watch Episode 167 Today’s GPCR scientists don’t want to study one interaction, they want to model the protein interactions  (e.g., 14-3-3) Heterodimerization Endogenous vs. overexpressed systems Orphan GPCR scientists are already expanding this work, bringing in computational layers  like AlphaFold to model GPCR-RAMP Listen to the complete episode to learn more. _________________ Keyword Cloud : GPCR scientist network , GPCR online course , GPCR data platform , multiplex assays , GPCR drug discovery

This technique has uncovered fundamental aspects of the G protein-coupled receptor (GPCR) function, including resurgence in recent times for exploratory analyses to identify previously unknown regions critical to GPCR In summary, mutagenesis can be a critical tool in drug discovery, particularly for studying GPCRs. The directed evolution of ligand specificity in a GPCR and the unequal contributions of efficacy and Molecular determinants of ligand efficacy and potency in GPCR signaling.

GPCR Symposium on GPCR activation and signaling a resounding success! GPCR Partnered Events April 22 - 23, 2024 | Endocrine Metabolic GPCRs Join the Endocrine Metabolic GPCRs Let’s dive into the Classified GPCR News from March 11th to 17th, 2024 Adhesion GPCRs ADGRG1, an adhesion Events, Meetings, and Webinars March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar GPCR Ecosystem

GPCR Symposia TOMORROW, we are hosting a symposium on GPCR activation and signaling. GPCR Partnered Events April 22 - 23, 2024 | Endocrine Metabolic GPCRs Join the Endocrine Metabolic GPCRs Let’s dive into the Classified GPCR News from March 4th to 10th, 2024 GPCR Activation and Signaling Glu1022.53 Deciphering the role of GPCRs in obesity pathology for drug development GPCR Events, Meetings, and Webinars GPCR Ecosystem

and 2 GPCR events! GPCR Partnered Events 3rd GPCRs - Targeted Drug Discovery Summit  Join us at the 3rd GPCRs Targeted Drug proprietary CCR8 antibody candidate to the clinic Novo strikes another obesity drug deal Sosei Heptares Webinar Xavier Leroy appointed as CEO of GIO Therapeutics GPCR Events, Meetings, and Webinars NOW! GPCR Ecosystem

September 2022 "Background and purpose: The interaction of arrestins with G-protein coupled receptors (GPCRs GPCRs that internalize without arrestin have been classified as "class A" GPCRs whereas "class B" GPCRs The interaction of arrestins with GPCRs requires both agonist activation and receptor phosphorylation Here, we ask the question whether agonists with very slow off-rates can cause the formation of particularly Read more at the source #DrGPCR #GPCR #IndustryNews

Check out our GPCR coverage for this week. April 22 - 23, 2024 | Endocrine Metabolic GPCRs Join Dr. GPCR Founder Dr. Events, Meetings, and Webinars February 20, 2024 | Career Opportunities in Pharmacology and Drug Discovery 13 - 15 | 9th German Pharm-Tox Summit March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar GPCR Ecosystem

We are thrilled to present our comprehensive GPCR coverage for the week; we have 14 GPCR papers, six GPCR Symposia Our upcoming symposium on March 15th is about GPCR activation and signaling. April 22 - 23, 2024 | Endocrine Metabolic GPCRs Join Dr. GPCR founder Dr. Events, Meetings, and Webinars February 20, 2024 | Career Opportunities in Pharmacology and Drug Discovery GPCR Ecosystem

Check out our GPCR coverage for this week. GPCR Symposia Our upcoming symposium on March 15th is about GPCR activation and signaling. Events, Meetings, and Webinars February 20, 2024 | Career Opportunities in Pharmacology and Drug Discovery 13 - 15 | 9th German Pharm-Tox Summit March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar GPCR Ecosystem

GPCR Podcast Episode 154 of the Dr. GPCR Consortium: The 11th Adhesion GPCR Workshop will take place in vibrant Mexico City from October GPCR Activation and Signaling Highly biased agonism for GPCR ligands via nanobody tethering Mechanistic Events, Meetings, and Webinars June 2 - 7, 2024 | Chemotactic Cytokines June 4, 2024 | Live Webinar GPCR Ecosystem