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Career opportunities:  Explore a selection of high-level job openings in high-throughput screening, research

The real killer, however, is apnea—those silent pauses where oxygen saturation crashes, often missed

Hexahydroquinoline Derivatives are Selective Agonists for the Adhesion G Protein-Coupled Receptor ADGRG1

Development and Characterization of a Highly Selective Turn-On Fluorescent Ligand for β3-Adrenergic Receptor

Submit poster abstracts via this form; short talks will be selected.

Submit poster abstracts using this form; short talks will be selected from submissions.

ERK activation GPCR Binders, Drugs, and more Flipping the GPCR Switch: Structure-Based Development of Selective

GPCR signaling and utilising advanced assay technologies, researchers can identify novel drugs that selectively

Vesicle-associated membrane protein 2 is a cargo-selective v-SNARE for a subset of GPCRs.

It silently shuts down opportunity. You might still get the meeting.

Molecular Insights into GPCR Function Endogenous l- to d-amino acid residue isomerization modulates selectivity

Biased signaling, allosteric binding sites, and subtype selectivity mean there is rarely a straight line

If you have registered, please submit poster abstracts through this form and the short talk selections

Submit poster abstracts here; short talks will be selected from Abstracts.

and Signaling Constitutive activation mechanism of a class C GPCR Allosteric modulation and G-protein selectivity

B) Orthogonal projections on a selected area of images in A. Scale bar: 20 μm. Biochim Biophys Acta. 2014 Jan;1838(1 Pt A):15-33. doi: 10.1016/j.bbamem.2013.09.005.

GPCRs-Targeted Drug Discovery Summit, Boston MA Pathios Therapeutics Unveils PTT-4256, a Highly Potent and Selective

into proximity-dependent proteomics of adenylyl cyclase isoforms, a case for functionally Gs protein-selective

Developing a novel framework for structure-based pharmacophore model generation and selection.

discovery referring to important conformational changes, allosteric properties, ligand and functional selectivity

and biased sampling method for Huntington's disease therapy Rational design of highly stabilized and selective

These optimizations enabled dual-color labeling strategies, surface-selective imaging, and ultimately

data can guide the modification of the chemical structure of the lead compounds to improve potency and selectivity

alkaloid malbrancheamide reorients the lipid binding domain of GRK5 Molecular Determinant Underlying Selective

Identification of 1,3,8-triazaspiro[4.5]decane-2,4-dione Derivatives as a Novel Delta Opioid Receptor-Selective

involved in visual processing Reliability of AlphaFold2 Models in Virtual Drug Screening: A Focus on Selected

modulate biased signaling downstream of CXCR3 depending on their subcellular localization Investigating selectivity

allosteric regulation of chemokines and antagonists using a nanoscale hCCR3 receptor sensor GPCR-G protein selectivity

October 3rd to 31st, 2024, to learn more about the Advanced Methods for the Optimization of Candidate Selection

Kenakin  showed how the same agonist can behave as near-full, partial, or even silent depending on receptor