. 📝 Manuscript summary deadline: 23 Sept 2025 📄 Submission deadline: 11 Jan 2026 Submit to Volume II Join the conversation on computational targeting and next-gen selectivity.

Kenakin argues, every downstream variable becomes distorted —from preclinical modeling to dose selection

Individual cancer types were enriched for highly impactful, recurrent mutations at selected cognate positions

The potent BECN2-ATG14 coiled-coil interaction is selectively critical for endolysosomal degradation

A ligand-based peptide probe could, offer the consistency and surface selectivity GPCR imaging demands

The impact of ACEA is inhibited by the selective CB1 receptor antagonist, rimonabant.

, you’ll learn how dialing receptor expression/coupling up or down reveals hidden partial agonism, “silent

GPCRs in Neuroscience Conformationally Selective 2-Aminotetralin Ligands Targeting the alpha2A- and alpha2C-Adrenergic

Submit your abstracts for poster presentation using this form - short talks will be selected from these

from β-arrestin interaction and demonstrates altered regulatory outcomes downstream of this functional selectivity

In July 2025, Superluminal Medicines announced advancing a selective, biased, MC4R agonist small molecule

Industry News Arcoscreen selected by START Lausanne to pitch at the START Global summit on the 23-24th

Synthetic signaling platforms permitting precise and selective Ca2+ signal transduction can improve dissection

Traditionally, it was believed that GPCRs selectively activate only their cognate G protein subtypes,

In contrast, when the GPR55 receptor is simulated in complex with the selective agonist ML186, agonist-like

dimerization of GLP-1R results in decreased high-affinity binding to its natural ligand, GLP-1, while selectively

Screening technologies, structure-informed design, and AI are accelerating target selection.

fluorescence chemistry, Celtarys custom-developed ligands offer both high affinity and exceptional selectivity

Chem Rev. 2017 Jan 11;117(1):139-155. Greater specificity : allows for selective tracking of receptor subtypes in complex brain tissues. Chem Rev. 2017 Jan 11;117(1):139-155. doi: 10.1021/acs.chemrev.6b00177 Alavi MS, Shamsizadeh A, Azhdari-Zarmehri

publications:  From on stabilizing RGS2 via modulating its degradation (versus direct inhibition); selectivity

Why it matters now: Cleaner signal:  Selective excitation + low background reduces false positives in

analysis restricted to variants impacting gene function Interaction modes of human orexin 2 receptor with selective

Career opportunities:  Explore a selection of high-level job openings in high-throughput screening, research

The real killer, however, is apnea—those silent pauses where oxygen saturation crashes, often missed

conformation with GFP-inspired dyes Structural basis for the ligand recognition and G protein subtype selectivity

While some receptors selectively activate specific G protein families, others are more versatile, yielding resonance energy transfer (BRET), and multi-color fluorescence microscopy assays employ conformation-selective

Methods & Updates in GPCR Research Development and Characterization of a Highly Selective Turn-On Fluorescent

Selection of the libraries typically leads to the isolation of several hundred candidate hits, enriched initial search for potent target receptor modulators is agnostic towards signaling activity because it selects While the native ligand conjugate exhibited poor selectivity for CCR5-expressing cells and was less effective unconjugated MMAE, the Orion CCL5 superagonist analog significantly increased both the potency and selectivity

It silently shuts down opportunity. You might still get the meeting.

Biased signaling, allosteric binding sites, and subtype selectivity mean there is rarely a straight line