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Results found for "Umut Onur Özcan"
- How System-Level GPCR Thinking Prevents Discovery Failures
GPCR is a 501(c)(3) non-profit organization—your participation directly supports our mission to advance
- From Farm Fields to GPCR Discovery, GLP-1 and GIP
This conversation is part of a three episode series produced in collaboration with our partners at Celtarys
- Phenylalanine 193 in Extracellular Loop 2 of the β 2-Adrenergic Receptor Coordinates β-Arrestin ...
Our studies reveal that F193 in extracellular loop 2 in the β2-adrenergic receptor mediates interactions
- Embark on a GPCR Adventure: Your Weekly Research Expedition! | Oct 21-27, 2024
This Week’s Highlights: Congrats to: John Teye Azietaku , our great contributor, for his article Class
- Allosteric Effect of Nanobody Binding on Ligand-Specific Active States of the β2 Adrenergic Receptor
Altogether, our results provide insights into the effect of intracellular binding partners on the GPCR
- Integrating Fluorescent Ligands into Flow Cytometry: Enhancing GPCR Analysis Beyond Traditional Antibody Staining
pharmacophores may be used in conjunction with fluorescent tags to study biased signaling pathways, improving our
- Navigating the Signaling Network: RTK and GPCR Crosstalk Uncovered
These findings enhance our understanding of cellular signaling dynamics and open new avenues for therapeutic
- How to Use Statistical Methods to Strengthen Every GPCR Drug Discovery Decision
Access this week’s full Premium Edition here ➤ What our members say 🗣️ "The content had enough depth
- The Perils and Guardrails of Modifying Signalling Proteins in Bioassays
Kiyan Afzali ‘What we observe is not nature itself, but nature exposed to our method of questioning As researchers of these prime targets, it is our duty to routinely clean our lens of misleading artefacts and focus our efforts towards the most physiologically relevant observations.
- Deficiency of β-arrestin2 alleviates apoptosis through GRP78-ATF6-CHOP signaling pathway in ...
In summary, our results suggest that excessive activation of GRP78-ATF6-CHOP apoptosis signaling is involved
- 📰 GPCR Weekly News, April 17 to 23, 2023
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- When the Islet Lit Up: Advancing GPCR Imaging in Native Tissue
This conversation is part of a three episode series produced in collaboration with our partners at Celtarys
- Self-docking and cross-docking simulations of G protein-coupled receptor-ligand complexes
Our results show that one specific subset of cross-docking simulations gave results of similar quality
- The Truth About GPCR Product Launches: Years in the Making
But the moment we got bench-level data that aligned with our design—it became a breakthrough.” — Dr.
- Neuronal Gα subunits required for the control of response to polystyrene nanoparticles in the ...
Our results provide clues for understanding the important function of GPCRs-Gα signaling cascade in the
- Unveiling GPCR Priming: The Hidden Synergy in Cellular Signalling
In conclusion, GPCR priming represents a compelling area of research that promises to deepen our understanding
- 📰 GPCR Weekly News, May 22 to 28, 2023
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- How Collaboration Drives GPCR Discoveries
This conversation is part of a three episode series produced in collaboration with our partners at Celtarys
- 📰 GPCR Weekly News, May 1 to 7, 2023
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- 📰 GPCR Weekly News, July 17 to July 23, 2023
Our Dr. GPCR Symposium on Structural and Molecular Insights on GPCR Activation was a success!
- Orthosteric vs. Allosteric Interactions: The Silent Decider of Safety and Success
Watch our new trailers for a preview of expert-led GPCR training designed for scientists and drug hunters
- Optimizing HTRF Assays with Fluorescent Ligands: Time-Resolved Fluorescence in GPCR Research
This assay utilized our fluorescent ligand, CELT-335 , designed for hCB 1 /CB 2 cannabinoid receptors
- Targeting GPCRs in the CNS: Advances in Drug Discovery Strategies
As mentioned in previous posts, CELT-335, one of our fluorescent compounds, was successfully employed
- How Advanced GPCR Kinetics Sharpen Decision Making (and Save You Time)
Access this week’s full Premium Edition here ➤ What our members say "Dr.
- Mechanism vs. Assumption: A Model-First Path to Getting GPCR MoA Right
Access this week’s full Premium Edition here ➤ What our members say 🗣️ "The best pharmacology teacher
- Dr. GPCR University registration is now open! Secure your spot now!
We’re thrilled to announce our upcoming courses with Dr. Terry Kenakin!
- Fentanyl and Xylazine: Why Breathing Fails in Overdose
For scientists, they sharpen our understanding of how different GPCR systems interact to produce respiratory
- Why Kinetics Matter More Than Kd in GPCR Drug Discovery
Kenakin is a masterful teacher and communicator—and a leading expert in our field.” — Dr.
- 📰 GPCR Weekly News, August 21 to 27, 2023
Our poster session is now a Kumospace discussion.
- 📰 GPCR Weekly News, April 3 to 9, 2023
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