Chris Tate co-founded Heptares after reading one paper on a Friday afternoon. . << Back to podcast list Strategic Partner(s) Chris Tate: Thermostabilizing GPCRs for Structural Biology Chris Tate spent years working on membrane proteins that were simply too unstable to study by crystallography ABOUT THE GUEST Chris Tate is a group leader at the MRC Laboratory of Molecular Biology in Cambridge, Chris Tate obtained his Ph.D. from the University of Bristol in 1989 and then moved to the University

Marshall walks through the decade when membrane proteins kept failing to crystallize in detergent, and how Chris Tate's thermostabilization strategy finally made GPCR structures routine, the insight that seeded Heptares Chris Tate's thermostabilization strategy, which introduced stabilizing mutations selected by thermal Chris Tate and Dr. Richard Henderson at the Laboratory of Molecular Biology in Cambridge, UK. It takes <60 seconds and makes a big difference. ★ Review on Apple Podcasts ★ Rate on Spotify ✉️ Send

<< Back to podcast list Strategic Partner(s) Chris Langmead Chris Langmead is Professor, Deputy Director in drug discovery, particularly in the field of psychiatry, where he has led multiple projects into late Prior to joining Heptares, Chris was a neuroscience researcher at GlaxoSmithKline, UK (1998-2009). Chris serves on the editorial boards of the British Journal of Pharmacology, ACS Chemical Neuroscience It takes <60 seconds and makes a big difference. ★ Review on Apple Podcasts ★ Rate on Spotify ✉️ Send

Clarke and completed postdoctoral work at AstraZeneca, with Brigitte Kieffer in Strasbourg, and with Chris Chronic states are not scaled-up acute states. One of Dr. They're not in the same state as they were if they were naïve. Chris Evans at UCLA. It takes <60 seconds and makes a big difference. ★ Review on Apple Podcasts ★ Rate on Spotify ✉️ Send

Vaithish obtained dual bachelor’s degrees with honors in Medical Biochemistry and Microbiology from Kansas State He then received a prestigious Gates Cambridge Scholarship to study for a Ph.D. at the MRC Laboratory It takes <60 seconds and makes a big difference. ★ Review on Apple Podcasts ★ Rate on Spotify ✉️ Send

addictions, one of the most consequential changes is the shift from goal-directed to habitual behavior: a state The tools arrived late relative to the questions. If you take that approach, you'll have plenty of moments where you realize that a new tool could take Kari Johnson on the web LinkedIn Google Scholar Research Gate USU Twitter Dr. It takes <60 seconds and makes a big difference. ★ Review on Apple Podcasts ★ Rate on Spotify ✉️ Send

from a Vietnam War draft to the cloning of the beta-2 adrenergic receptor — and reflects on what it takes At a 1973 symposium, Ahlquist responded to Lefkowitz's research plans by stating in print that hormone The 98% rule and what it means to take on important problems Dr. "If half of everything I'm trying to do is working, I'm not taking on very challenging stuff. It takes <60 seconds and makes a big difference. ★ Review on Apple Podcasts ★ Rate on Spotify ✉️ Send

molecular mechanisms of MRAP2 regulation of the GHSR1a, and where I notably developed the C-terminal gate This theory states that the post-translational modification of GHSR1a’ C-terminal tail is not a docking It takes <60 seconds and makes a big difference. ★ Review on Apple Podcasts ★ Rate on Spotify ✉️ Send

An estimated ten billion dollars is spent every year in the United States rebuying reagents already sitting COVID-era conversations about why vaccines take eighteen months tend to focus on the clinical and regulatory with two teenagers in the same high-school classroom, different majors, different career paths, and a late-night reagents will run out 22:43 A weekly release cycle built around user feedback 24:13 Why vaccines still take It takes <60 seconds and makes a big difference. ★ Review on Apple Podcasts ★ Rate on Spotify ✉️ Send

opportunity in existing drug pipelines Antibody therapeutics for GPCRs - the pipeline case, the approval rate Antibody therapeutics for GPCRs: the pipeline argument Biologics have a substantially higher success rate found agonists: compounds that made the G-protein bind better, some of which trapped the receptor in a state Annette Gilchrist on the web LinkedIn Midwestern University Google Scholar Pubmed Twitter Research Gate It takes <60 seconds and makes a big difference. ★ Review on Apple Podcasts ★ Rate on Spotify ✉️ Send

Roland Beckmann with a brief stay at Cambridge University, UK, working in the lab of the late Dr. I next moved to Rockefeller University in NYC to work in the lab of the late Dr. It takes <60 seconds and makes a big difference. ★ Review on Apple Podcasts ★ Rate on Spotify ✉️ Send

publications that, in the same year, established inactive, active, and intermediate conformational states the subunit composition of GABA-B to holding cryo-EM structures in inactive, active, and intermediate states and what the mu opioid receptor example demonstrated 23:37 - What full-length structures in multiple states Fan at Columbia University Research Gate LinkedIn Pubmed Dr. GPCR Ecosystem Unlock the Full Dr. It takes <60 seconds and makes a big difference. ★ Review on Apple Podcasts ★ Rate on Spotify ✉️ Send

Gainetdinov is the Institute of Translational Biomedicine Director at Saint Petersburg State University Raul Gainetdinov on the web Saint-Petersburg State University Wikipedia Google Scholar Researchgate Google It takes <60 seconds and makes a big difference. ★ Review on Apple Podcasts ★ Rate on Spotify ✉️ Send

He obtained his Ph.D. in Neuroscience from Ohio State University focusing on synaptic plasticity and By taking a very non-traditional path to obtain a Ph.D. Dr. It takes <60 seconds and makes a big difference. ★ Review on Apple Podcasts ★ Rate on Spotify ✉️ Send

Matthew Eddy Matthew Eddy earned his BA in Chemistry from Oberlin College, where he trained with solid-state It takes <60 seconds and makes a big difference. ★ Review on Apple Podcasts ★ Rate on Spotify ✉️ Send

training, he completed his doctoral work on circadian regulation of prolactin secretion at Florida State cytoplasmic effector-binding pocket with its own independent affinity, both modulated by the conformational state I hate to say it because it's so overused, but it really is an art form and everybody approaches it differently He obtained both his MS and Ph.D. in Neuroendocrine Physiology at Florida State University before completing It takes <60 seconds and makes a big difference. ★ Review on Apple Podcasts ★ Rate on Spotify ✉️ Send

Nicole (Nicki) Perry-Hauser on the web LinkedIn Research Gate Pubmed Dr. It takes <60 seconds and makes a big difference. ★ Review on Apple Podcasts ★ Rate on Spotify ✉️ Send

analysis — to catalog which receptors are actually highly expressed across human tissues and disease states Insel's late-career pivot began with a deceptively simple question: are we studying the right GPCRs? "If you ask a biochemist how does a television work, he would probably take a wrecking ball to it and It takes <60 seconds and makes a big difference. ★ Review on Apple Podcasts ★ Rate on Spotify ✉️ Send

She received her Ph.D. from Oklahoma State University and completed her postdoctoral training with Dr It takes <60 seconds and makes a big difference. ★ Review on Apple Podcasts ★ Rate on Spotify ✉️ Send

I received my PhD in Biology at Arizona State University, where I worked in the lab of Miles Orchinik It takes <60 seconds and makes a big difference. ★ Review on Apple Podcasts ★ Rate on Spotify ✉️ Send

Dmitry studied biophysics at the Moscow State University, followed by a PhD (1998) in protein folding at the Russian Academy of Sciences and at the Ohio State University, USA. It takes <60 seconds and makes a big difference. ★ Review on Apple Podcasts ★ Rate on Spotify ✉️ Send

Explore how GPCR signaling shapes mosquito feeding and mating behaviors with Dr. Laura Duvall. Back to podcast list Strategic Partner(s) Why Mosquitoes Hunt You: GPCR Control of Blood Feeding and Mating GPCRs—especially neuropeptide Y (NPY) receptors—regulate innate behaviors such as blood feeding and mating It takes <60 seconds and makes a big difference. ★ Review on Apple Podcasts ★ Rate on Spotify ✉️ Send

Prasad Pydi on the web Molecular Metabolism & Cell Signaling Laboratory Website Twitter.com Research Gate It takes <60 seconds and makes a big difference. ★ Review on Apple Podcasts ★ Rate on Spotify ✉️ Send

bioluminescence resonance energy transfer technologies (FRET, BRET) that were used for functional screens with state-of-the-art It takes <60 seconds and makes a big difference. ★ Review on Apple Podcasts ★ Rate on Spotify ✉️ Send

prestigious academic laboratories as well as in biopharmaceutical companies in Europe and the United States It takes <60 seconds and makes a big difference. ★ Review on Apple Podcasts ★ Rate on Spotify ✉️ Send

Bruns Fred Bruns discovered the first positive allosteric modulator (PAM) of a GPCR in the late 1980s It takes <60 seconds and makes a big difference. ★ Review on Apple Podcasts ★ Rate on Spotify ✉️ Send

Similar strategic considerations shaped the fate of the EP4 partial agonist that ultimately found a niche considerations in choosing receptor-rich tissues. 05:00 — Transition from academia to Glaxo, early HIV TAT , using Southern blots to hunt for a non-existent AT1 subtype, and the MAS oncogene as a cautionary tale It takes <60 seconds and makes a big difference. ★ Review on Apple Podcasts ★ Rate on Spotify ✉️ Send

the scientific conversations that matter most. 1,400+ GPCR scientists reached 25–50% Newsletter open rate Yearly Glow Exclusive Gated Content Premium content assets created in partnership — gated to capture This is real selectivity — a reflection of how seriously we take partner quality and community trust.

on the web Twitter University of Minnesota Department Page LinkedIn Google Scholar PubMed Research Gate It takes <60 seconds and makes a big difference. ★ Review on Apple Podcasts ★ Rate on Spotify ✉️ Send

predictions with real-world pharmacological readouts If you see the research value in collaborative, up-to-date It takes <60 seconds and makes a big difference. ★ Review on Apple Podcasts ★ Rate on Spotify ✉️ Send