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Nguyen ,  Ziaurrehman Tanoli ,  Saad Hassan , Umut Onur Özcan ,   Jimmy Caroli ,   Albert J Kooistra ,   David E Gloriam ,   Alexander S Hauser GPCRdb in 2025: adding odorant receptors, data mapper, structure similarity Taracena Herrera , Søren N Andreassen ,   Jimmy Caroli ,   Albert J Kooistra , Gáspár Pándy-Szekeres ,   David E Gloriam , et al.

neuroprotective mechanism involving interaction between neurotrophic factor-α1 (NF-α1/carboxypeptidase E,

David Gloriam and Dr. Albert Kooistra.

and chemistry pulled him into the world of GLP-1R, pancreatic β-cells, and the biological questions David The call from David — the glowing islet — created a pivot the team couldn’t ignore. He learned tissue complexity from David; David picked up the quirks of acetonitrile. David Hodson

David Gloriam , Dr.

David Hodson needed molecules that were only one synthetic step beyond what JB was already making. When David later shared early data — including a moment where he realized he could image an entire islet David brought deep experience in islet biology, calcium imaging, and tissue physiology. David picked up unexpected chemistry insights — including a well-loved lesson involving acetonitrile David Hodson

Watch Episode #177 The Experiment That Was Never Meant to Succeed When David Hodson’s lab teamed up with David Hodson

E. S.; Vahlberg, T.; Lahdenpohja, S.; Rinne, J. O.; Brück, A. E. E. .; Zirwes, E. .; Trinquet, E.; Pin, J.-P. E.

Lukas Grätz, David Gloriam, and Gunnar Schulte’s research on Unveiling pathway selectivity in Frizzleds

This week's highlight includes congrats to: Clementine E Philibert and Mikel Garcia-Marcos for their spatial, temporal and ligand bias of G protein-coupled receptors Antonios Drakopoulos, Peter Gmeiner, Davide

David Gloriam and his team present GproteinDb in 2024 Are you looking to hire?

Nov 8; 13:RP97033. doi: 10.7554/eLife.97033.3   Maurel D, Comps-Agrar L, Brock C, Rives ML, Bourrier E, Ayoub MA, Bazin H, Tinel N, Durroux T, Prézeau L, Trinquet E, Pin JP. Navarro G, Sotelo E, Raïch I, Loza MI, Brea J, Majellaro M.

E, 2002). E., et al. 2008). E., et al. 2008).

This week's highlight includes congrats to: David A Cooper, David Minh, et al., for their research on

D., Rands, E., Diehl, R. E., Mumford, R. A., Slater, E. E., Sigal, I. S., Caron, M.

Source: Navarro G, Sotelo E, Raïch I, Loza MI, Brea J, Majellaro M. References Navarro G, Sotelo E, Raïch I, Loza MI, Brea J, Majellaro M. Degorce F, Card A, Soh S, Trinquet E, Knapik GP, Xie B.

J., Pardon, E., Casarosa, P., Chae, P. S., Devree, B. T., Rosenbaum, D. M., Thian, F. M., Manglik, A., Hu, J., Hu, K., Eitel, K., Hübner, H., Pardon, E., Valant, C., Sexton, P. M., Dukkipati, A., Feinberg, E. N., Angelini, A., Waghray, D., Dror, R. O., Ploegh, H. D., Tworak, A., Watanabe, K., Pardon, E., Steyaert, J., Kandori, H., Katayama, K., Kiser, P.

Matthew E. on Friday, October 7th at 1 PM ET.

GPCR phosphorylation patterns, which influence their conformational states and functions (Matthees, E. E. et al. 2022). E. et al. 2017). evolutionary conservation of both isoforms from fish to mammals indicates their non-redundant roles (Gurevich, E. determining the formation of protein complexes and their functions within specific tissues (Matthees, E.

That is, besides classical ligands, a great number of bivalent ligands (i. e. aiming on two distinct

David Hodson

David Hodson walks through how his team uses fluorescence tools and chemically engineered ligands to

However, Trinquet’s team, in collaboration with Professor David Parker from Durham University, cracked

It’s the product of layered collaborations—with Durham University chemist David Parker on the probe chemistry

References Barbazán J, Majellaro M, Martínez AL, Brea JM, Sotelo E, Abal M. Sridharan R, Zuber J, Connelly SM, Mathew E, Dumont ME.

E., Vitale, R. M., Tomašević, N., ... & Carreira, E. M. (2024).

David Parker spent years designing rare-earth europium probes.

E., & Puthenveedu, M. A. (2021). Compartmentalized GPCR Signaling from Intracellular Membranes. E., Healy, M. D., & Collins, B. M. (2019). E., French, R. P., Lowy, A. M., & Murray, F. (2018).

David Hodson

showed spontaneously fluctuating Ca levels from approximately normal to near fatally high ranges, (e)