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Strategic approaches to building GPCR research programs that translate fundamental discoveries into clinical impact and drug development. < Back How to Build Breakthrough GPCR Programs June 4, 2026 10 AM - 11: Introduction Building GPCR research programs that achieve both fundamental discovery and clinical translation

Silvio Gutkind: Building a Lab That Doesn't Shut Down Conversations that happen when a research community Gutkind — carrying a personal loss in New York and leading a cancer center building that operated at He walks through the structure his team built: staggered schedules at 10–15% occupancy, written contracts Gutkind a pre-built mental model for what to freeze, what to protect, and what to let continue. The contract wasn't bureaucracy; it was protection, especially for students.

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Short bursts of stress—whether exercise, cold exposure, or sympathetic activation—can trigger adaptive

The rooms in your professional home University isn't a bundle of features — it's a place where your GPCR Andrew Tobin | Glasgow University How to Build Breakthrough GPCR Programs Research Strategy June 4, 2026

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Andrew Tobin | Glasgow University How to Build Breakthrough GPCR Programs Research Strategy Details May

Brown sitting with a table of actives and inactives — was that the active condition was the acetate buffer set a career in motion 07:07 A venture capital visit to the LMB and the founding of Heptares 11:28 Building ignoring GPCRs 36:39 The GABA-B heterodimer — the moment baclofen finally worked 40:06 The acetate-in-the-buffer

is not machine learning, and neither is simple computational modeling) to the practical realities of building An MD-PhD who has practiced machine learning since 1989, he built Pharos, the public-facing data platform Buffers, incubation temperatures, time points, co-expression conditions, the specific Emax reference

GPCR during COVID — the career arc behind the ecosystem built for the field's unreached receptors. << belong to a family she believes has been collectively underserved by the infrastructure around it, and building She now builds scientific community infrastructure for the GPCR field. perspective — which she explicitly values — comes at the cost of the field-level view that ecosystem-building Building during a pandemic is a design constraint, not a footnote. Dr.

Aaron Sato on building the synthetic antibody library that finally makes GPCRs tractable — and the greenfield This conversation explores how synthetic antibody phage display libraries, built on silicon-based DNA For Aaron, this work is personal: he has built his career hunting greenfield targets where others had His current focus is building synthetic phage display libraries that drug targets the field has long

Her "bugaboo": we still do not know reliably where many GPCRs live — which cell type, which compartment Her move from pure opioid pharmacology into migraine came from sharing a building with neurologist Andrew

Antonella Di Pizio on building computational models for GPCRs with almost no crystal structures and almost Ectopic expression of taste and odorant receptors beyond their namesake tissues Persistence, career building Di Pizio's workflow is deliberately iterative: build the model, predict binding-site residues, send them

His training began at the University of Buenos Aires on alpha-2 adrenergic receptors, continued at the And the 12 people who moved cross-country from NIH to UCSD did so because of relationships built over Episode Timeline 00:00 Introduction 02:09 From Buenos Aires to NIH: a career that followed the science These took him from the University of Buenos Aires in Argentina to UC San Diego and through the National

quantitative model turned her artifacts into real pharmacological responses, the throughline has never been building Piñeyro's answer is blunt: she does not think of herself as having built a career. I was not building a career. I was simply following my interests." About this episode Dr.

off-label drug use during a pandemic Key Insights from the Conversation The ACE inhibitor scare was built Nature has built in these systems consistently." — Dr.

the shutdown, including a newly accepted BRET-based platform for beta-1 adrenergic receptor signaling built Hebert, the conversation is also about what he had to let go of: the assumption that a lab, once built The beta-1 adrenergic receptor paper — a BRET-based platform for capturing downstream signaling, built

Rebuilding the Software Layer Under Modern Research Most scientific research still runs on infrastructure built Trained in electrical and computer engineering, he began his career at General Atomics building software Excel is the default research tool because no one built a better one for scientists. The co-founders argue that most lab software wasn't built for scientists — it was built for general business Cho describes shipping updates weekly, prioritizing customer-reported bugs and feature requests with

This is not a quirk — it is the central clue the lab has built a therapeutic strategy around. A trained pharmacologist's first instinct is that the side effect burden would be crushing.

invisible to bench scientists, ranging from medical science liaison and clinical research roles to business

Built for serious scientists. University / Masterclass On Demand Every Masterclass session. GPCR & Yamina's Corner Community builder for scientists with expertise in GPCR project strategy and translational

InterAx treats GPCR pharmacology the way engineers treat aircraft design: build the mathematical model Young founders should not build alone.

Director of Graduate Studies of Experimental Therapeutics at Roswell Park Comprehensive Cancer Center in Buffalo

John explained that he was drawn to chemistry because it allowed him to build things in his mind and interest in graduate school, inspired by the innovative approach of using chemistry to understand and build John suggested building milestones and landmarks into a postdoc, such as applying for funding opportunities

He has successfully built numerous global life science, leadership teams, & works closely with both clients

Caron has received numerous awards including a Burroughs Wellcome Fund Career Award in the Biomedical

Nigel Bunnett at the NYU Pain Research Center as a postdoctoral researcher. Lastly, they concurred on the collaborative nature of the scientific community, where scientists build Additionally, they both agreed on the importance of mentorship in building confidence, with Yamina sharing

Ilana Kotliar built a multiplexed platform to map GPCR-RAMP interactions and uncover autoantibody-driven She expanded the original Family B focus to encompass the entire GPCR superfamily , building a digital

structural biology—and where it still falls short Advice for junior scientists: what really matters when building That moment launched a career built around using computational tools to answer big biological questions Jens is passionate about prediction over explanation: building models that can guide experiments, not

It’s an eight-year-plus haul with built-in uncertainty. Serafini Pivoting: Redefining the Pain Research Playbook Looking ahead, Serafini’s vision is bold: build “Start from the end — from the clinic — and then build backwards.” — Alex Serafini Key Takeaway Innovation