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GPCR targeting of E3 ubiquitin ligase MDM2 by inactive β-arrestin.

Endosomal signaling via cAMP in parathyroid hormone (PTH) type 1 receptor biology β-arrestin1 is an E3 ubiquitin ligase adaptor for substrate linear polyubiquitination GPCR Binders, Drugs, and more Dual

degradation of insulin-like growth factor 1 receptor (IGF1R) by competitively binding to IGF1R with ubiquitin E3 ligase MDM2, thereby activating its downstream signaling pathways such as NF-κB, PI3K/AKT, and MAPK

Structural basis for the ubiquitination of G protein βγ subunits by KCTD5/Cullin3 E3 ligase.

Xiaoyu Zhang showed great insight into new ligands for new E3 ligases for PROTAC development.

ADGRL1/LPHN1) increases the risk of obesity Norton Cheng, JoAnn Trejo, et al. for their research on Ubiquitin-driven Signaling Variable CGRP family peptide signaling durations and the structural determinants thereof Ubiquitin-driven

This methylation on a lysine residue at the N-terminal portion of β-catenin suppresses the ubiquitination

Divergent regulation of α-arrestin ARRDC3 function by ubiquitination.

GPCR Activation and Signaling The ancestral ESCRT protein TOM1L2 selects ubiquitinated cargoes for retrieval

mechanisms of β-arrestin1 and β-arrestin2 in regulation of cancer cell cycle and metastasis "β-Arrestins are ubiquitously contribution to GPCR desensitization to agonist-mediated activation, followed by receptor endocytosis and ubiquitylation

mechanisms of β-arrestin1 and β-arrestin2 in regulation of cancer cell cycle and metastasis "β-Arrestins are ubiquitously contribution to GPCR desensitization to agonist-mediated activation, followed by receptor endocytosis and ubiquitylation

Evidence demonstrated that the ligation of SDF-1 to CXCR4 initiates several intracellular signaling pathways

interaction of VLGR1 with key proteins of MAMs by pull-down assays in vitro complemented by in situ proximity ligation

Here, we used a proximity ligation assay (PLA)–based approach for the in situ visualization and quantification

September 2022 "Receptor-activity-modifying proteins (RAMPs) are ubiquitously expressed membrane proteins

and latex beads, it is critical for optimal macrophage capture of pathogenic fungi, including Hc, the ubiquitous

interchangeable in supporting rod phototransduction, replacement of retina-specific Gγ isoforms by the ubiquitous

Monoacylglycerol Lipase Protects the Presynaptic Cannabinoid 1 Receptor from Desensitization by Endocannabinoids

Although most ORs were not ubiquitously expressed in gliomas, a subset of ORs displayed glioma subtype-specific

MI was introduced to rats by permanent left anterior descending coronary artery (LAD) ligation.

GPCR Activation and Signaling Ubiquitylation of BBSome is required for ciliary assembly and signaling

In presynaptic terminals, membrane-delimited Gi/o-mediated presynaptic inhibition is ubiquitous and acts

2023 Dirk Loeffert CEO & Founder DesignPharma Interview GPCR-targeting drugs: A renewed focus on a ubiquitous

spermatozoa and is an example of a highly and selectively expressed OR, whereas OR51E1 and OR51E2 represent ubiquitously