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Results found for "E3 ubiquitin ligases"
- 📰 GPCR Weekly News, July 3 to 9, 2023
GPCR targeting of E3 ubiquitin ligase MDM2 by inactive β-arrestin.
- 📰 GPCR Weekly News, November 13 to 19, 2023
Endosomal signaling via cAMP in parathyroid hormone (PTH) type 1 receptor biology β-arrestin1 is an E3 ubiquitin ligase adaptor for substrate linear polyubiquitination GPCR Binders, Drugs, and more Dual
- GASP1 enhances malignant phenotypes of breast cancer cells and decreases their response to...
degradation of insulin-like growth factor 1 receptor (IGF1R) by competitively binding to IGF1R with ubiquitin E3 ligase MDM2, thereby activating its downstream signaling pathways such as NF-κB, PI3K/AKT, and MAPK
- 📰 GPCR Weekly News, July 10 to 16, 2023
Structural basis for the ubiquitination of G protein βγ subunits by KCTD5/Cullin3 E3 ligase.
- Maria’s Travel Blogs: ACSMEDI-EFMC Medicinal Chemistry Frontiers 2025
Xiaoyu Zhang showed great insight into new ligands for new E3 ligases for PROTAC development.
- 📰 GPCR Weekly News, April 22 to 28, 2024
ADGRL1/LPHN1) increases the risk of obesity Norton Cheng, JoAnn Trejo, et al. for their research on Ubiquitin-driven Signaling Variable CGRP family peptide signaling durations and the structural determinants thereof Ubiquitin-driven
- PAR-Induced Harnessing of EZH2 to β-Catenin: Implications for Colorectal Cancer
This methylation on a lysine residue at the N-terminal portion of β-catenin suppresses the ubiquitination
- 📰 GPCR Weekly News, May 22 to 28, 2023
Divergent regulation of α-arrestin ARRDC3 function by ubiquitination.
- 📰 GPCR Weekly News, April 24 to 30, 2023
GPCR Activation and Signaling The ancestral ESCRT protein TOM1L2 selects ubiquitinated cargoes for retrieval
- Deciphering the signaling mechanisms of β-arrestin1 and β-arrestin2 in regulation of cancer cell...
mechanisms of β-arrestin1 and β-arrestin2 in regulation of cancer cell cycle and metastasis "β-Arrestins are ubiquitously contribution to GPCR desensitization to agonist-mediated activation, followed by receptor endocytosis and ubiquitylation
- Deciphering the signaling mechanisms of β-arrestin1 and β-arrestin2 in regulation of cancer cell...
mechanisms of β-arrestin1 and β-arrestin2 in regulation of cancer cell cycle and metastasis "β-Arrestins are ubiquitously contribution to GPCR desensitization to agonist-mediated activation, followed by receptor endocytosis and ubiquitylation
- MSX-122: Is an effective small molecule CXCR4 antagonist in cancer therapy?
Evidence demonstrated that the ligation of SDF-1 to CXCR4 initiates several intracellular signaling pathways
- The Adhesion GPCR VLGR1/ADGRV1 Regulates the Ca2+ Homeostasis at Mitochondria-Associated ER Membrane
interaction of VLGR1 with key proteins of MAMs by pull-down assays in vitro complemented by in situ proximity ligation
- Dimerization of GPCRs: Novel insight into the role of FLNA and SSAs regulating SST2 and SST5...
Here, we used a proximity ligation assay (PLA)–based approach for the in situ visualization and quantification
- Functional modulation of PTH1R activation and signaling by RAMP2
September 2022 "Receptor-activity-modifying proteins (RAMPs) are ubiquitously expressed membrane proteins
- Genome-scale CRISPR screening reveals that C3aR signaling is critical for rapid capture of fungi...
and latex beads, it is critical for optimal macrophage capture of pathogenic fungi, including Hc, the ubiquitous
- Regulation of rod photoreceptor function by farnesylated G-protein γ-subunits
interchangeable in supporting rod phototransduction, replacement of retina-specific Gγ isoforms by the ubiquitous
- 📰 GPCR Weekly News, July 24 to July 30, 2023
Monoacylglycerol Lipase Protects the Presynaptic Cannabinoid 1 Receptor from Desensitization by Endocannabinoids
- Odorant G protein-coupled receptors as potential therapeutic targets for adult diffuse gliomas ...
Although most ORs were not ubiquitously expressed in gliomas, a subset of ORs displayed glioma subtype-specific
- Exendin-4 Attenuates Remodeling in the Remote Myocardium of Rats After an Acute Myocardial ...
MI was introduced to rats by permanent left anterior descending coronary artery (LAD) ligation.
- 📰 GPCR Weekly News, February 6 to 12, 2023
GPCR Activation and Signaling Ubiquitylation of BBSome is required for ciliary assembly and signaling
- Synaptic integration of subquantal neurotransmission by co-localized G protein coupled receptors in
In presynaptic terminals, membrane-delimited Gi/o-mediated presynaptic inhibition is ubiquitous and acts
- 📰 GPCR Weekly News, March 6 to 12, 2023
2023 Dirk Loeffert CEO & Founder DesignPharma Interview GPCR-targeting drugs: A renewed focus on a ubiquitous
- Odorant receptors – a bit of smell for drug discovery
spermatozoa and is an example of a highly and selectively expressed OR, whereas OR51E1 and OR51E2 represent ubiquitously


