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Results found for "Elva Zhao"
- From GPCR Data Chaos to Decisive Action
Work With ✅ Biotech Teams – Especially those lacking in-house GPCR leads or overwhelmed by CRO data chaos ✅ Most teams don’t need more data— they need clarity ✅ Yamina’s Corner helps teams move from data chaos
- A robust and Efficient FRET-Based Assay for Cannabinoid Receptor Ligands Discovery.
.; Zhao, S.; Shui, W.; Li, S.; Korde, A.; Laprairie, R. B.; Stahl, E. L.; Ho, J. .; Zhao, Q.; Hanson, M. A.; Bohn, L. M.; Makriyannis, A.; Stevens, R. C.; Liu, Z.-J. J.; Wang, J.; Wu, M.; Katritch, V.; Zhao, S.; Kunos, G.; Bohn, L. M.; Makriyannis, A.; Stevens, R. Chemistry 2020 , 188 , 112037. https://doi.org/10.1016/j.ejmech.2020.112037 . (15) Zhang, S.; Shao
- The Imprecision Problem: Why Your GPCR Drug Discovery Program Is Off-Track Before It Even Starts
Without clear rules of engagement, communication becomes chaos, progress gets lost in Slack threads, That’s a chaos tax — and you’re paying it in cash, time, and morale.
- Structural landscape of the Chemokine Receptor system
and the intracellular helix 8 move outward from the receptor core to make room for the G-protein (Lu, Zhao namely CCL15L (residues 26-92) and CCL15M (residues 27-92), while the third structure lacks a ligand (Shao conformational change of Y2917.43 tilted toward TM2, a model supported by mutagenesis experiments (Shao
- Feeder or trigger – CCR2 as a scavenger and regulator of cell migration
Zhao et al. 2019). Zhao et al. 2019) together with confocal fluorescence microscopy.
- Illuminating GPCR Research: FRET and BRET-Based Sensors Shed Light on Cellular Signaling
Zhao, P., et al., Activation of the GLP-1 receptor by a non-peptidic agonist.
- Competitive vs Non-Competitive GPCR Antagonists: How to Interpret Pharmacology Data with Confidence
Gain a competitive edge by transforming your GPCR data from chaos into a strategic asset, enabling faster Build predictable success: Use a repeatable improvement framework to turn operational chaos into precision
- Odorant receptors – a bit of smell for drug discovery
For example, OR4M1 was proposed to interfere with aberrant tau hyperphosphorylation (Zhao W. et. al 2013
- Allosteric Binding Demystified: Smarter GPCR Drug Discovery
Eliminate chaos tax: Every two-week delay in DMTA cycles costs hundreds of thousands—avoidable with
- GPCR Allosteric Modulation: Why Allostery is the Engine of Drug Discovery
This unpredictability isn’t chaos—it’s structure-driven , and when properly understood, it becomes a
- Is Your GPCR Drug Discovery Program Built for Breakthroughs or Breakdowns?
Learn how to build an integrated data pipeline that transforms this chaos into a strategic asset.
- How a Failed Med School Dream Sparked a GPCR Biotech Revolution
Where high-throughput screening saw chaos, Ajay saw patterns waiting to be decoded.
- 📰 GPCR Weekly News, June 3 to June 9, 2024
Zhan-Guo Gao, Mansour Haddad, and Kenneth A Jacobson for their work on A2B adenosine receptor signaling
- From Snapshots to Predictions: Why Mechanism of Action Matters
That’s the power of model-driven thinking—it takes chaos and reveals consistency.
- The Perils and Guardrails of Modifying Signalling Proteins in Bioassays
Shen S, Zhao C, Wu C, Sun S, Li Z, Yan W, et al.
- The Hidden Burn: How Internal Misalignment Drains Your Biotech’s Runway
How Misalignment Drains Your Runway 👉 Misalignment doesn’t show up as chaos.
- ⛵Sailing the GPCR Seas: Your Weekly Research Voyage! ⦿ Nov 11 - 17, 2024
Week’s Highlights: SNX9 family mediates βarrestin-independent GPCR endocytosis Valeria Robleto , Ya Zhuo
- VAMP2: a crucial player in the delivery of MOR to the synapse
Through developing a high-resolution method, Hao Chen et al. directly visualized the fusion of vesicles
- Exciting GPCR Events for Next Year! + GPCR Weekly Rocket Launch ⦿ Oct 28 - Nov 3, 2024
Highlights: Congrats to: Ya-Tzu Li , our notable contributor, for her superb undergrad paper along with Hao-Jen
