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Gregory Tall About Dr. Gregory Tall " Dr. Gregory Tall earned his Ph.D. in Biomedical Sciences from U.T. Tall joined the faculty in the Department of Pharmacology and Physiology at the University of Rochester Tall has been continuously funded by the NIH since receiving an early RO1 award at Rochester. Gregory Tall on the web The Tall Lab University of Michigan Google Scholar Twitter Dr.

Trained as a biochemist, he completed a PhD in protein engineering (Cambridge, UK) with Sir Gregory Winter

Randy Hall About Dr. Randy Hall Randy Hall, Ph.D., is a Professor of Pharmacology and Chemical Biology in the Emory University Randy Hall on the web Hall Lab LinkedIn Google Scholar ResearchGate Dr. Lefkowitz Memoir. Dr.

Michelle Halls reveals how organized GPCR signaling drives assay innovation and new therapeutic insights Michelle Halls In this episode Dr. Michelle Halls shares how dissecting the spatial organization of GPCR signaling opens new doors in drug About the Guest Michelle Halls is an Associate Professor at Monash University and Deputy Theme Leader More about Michelle Halls Monash Institute of Pharmaceutical Sciences Bluesky LinkedIn Articles about

“The team’s updates sound polished, but we can’t tell if they’re on track.” Translate project strategy into clear decision-driving assays Eliminate “nice to have” tests that stall I begin with a 30-minute call to understand your goals. * Send Message or Book My Call Menu Home Services About Ready to collaborate? GPCR Calendly ©2023-2025 All rights reserved by FindYooour, LLC & Dr.

it or not, this panel is an honest audit of what the technology can deliver today and where it still falls biological models The hybrid future: chemical intuition, experimental judgment, and where computation still falls And then a year later or so, I get a call from a colleague who said, 'oh, we've tested this compound He would look at the 2D structure and basically mentally do a docking and tell you whether that's a good Maria Waldhoer About this episode Listen to this fantastic round table discussion that I had the privilege

The adrenergic system was the only one that satisfied all three. It was the moment they understood that all GPCRs would share this architecture. 5. "He got up and said, it's all very nice. But he says, this is a figment of Dr. call him Robert, especially when she was upset with him. Randy Hall. Bob is James B.

A stalled labeling project on the NPY2 receptor during his PhD at Vanderbilt redirected his entire trajectory The stalled experiment was the origin point of the approach he now applies at family scale. The eureka of the whole family Months of manually reading sequence alignment tables - before Bender could from sparse data 07:44 Origin moment - a lab notebook at age 8 11:53 The NPY2 labeling project that stalled about what you're doing is way more valuable than just trying to do the next ten million experiments all

trials in focal segmental glomerulosclerosis and diabetic kidney disease - and watching protein levels fall Endpoint Assays Can Miss the Biology Entirely A single measurement at a fixed time point collapses all What made it humbling, he notes, were the calls from patients' families asking to get into the trial. These are all business skills. And these are all skills that can be transferred." Join me and learn more about Kevin’s work and how he manages all his responsibilities. Dr.

experimentalists are more vital than ever How AlphaFold is shaking up structural biology—and where it still falls Trained initially as a biotechnology engineer, Jens discovered his true calling during an internship

He shares: "All my industry experience has been GPCR-focused." Falling in Love with GPCRs GPCR pharmacology captured his scientific curiosity. He built what others called the “happiest team at Alkermes,” showing that joy and scientific rigor aren

Only recently has the field established, with confidence, that adhesion GPCRs couple to G proteins at all Paper During his graduate studies, Boucard left an enzymatic reaction on his bench over a weekend — called 31:33 The underground restaurant in San Francisco, born out of an immigration emergency — and Chef's Table lab for students no one else was recruiting 01:00:00 Adhesion GPCRs — the receptor family that kept calling announcement "If you willingly put yourself in a situation where you're willing to take risks, things will fall

. 👉 Book a Free 30-min Strategy Call Select your Challenge... ↑ Pick your challenge to see tailored Book Your Free Strategy Call GPCR University Team Membership Dr. Book a Strategy Call → Our Core Support Areas Discovery Consulting & Strategy Expert guidance to de-risk

The realization — triggered by Andrew Brown sitting with a table of actives and inactives — was that "He just sat down with a table of what was active or inactive. So it turned out that the ligands were not the peptides at all." As a co-founder of Heptares Therapeutics , now called Sosei Heptares , a GPCR-focused drug discovery

A harder question surfaces underneath: how much of what we call a lab is its physical walls, and how The bioinformatics arm called it "heaven." "I wouldn't call it social distancing — I would call physical distancing… as a community, we are even

formats biotech teams can use • Streamline deliverables to reduce review cycles and accelerate go/no-go calls * Send Message or Book My Call Menu Home Services About Ready to collaborate? Let’s talk about how I support GPCR discovery, pharmacology strategy, and cross-functional execution GPCR Calendly ©2023-2025 All rights reserved by FindYooour, LLC & Dr.

In the fall, Julia will begin her MD/PhD training.

I then started my career at Evotec before moving to Domain Therapeutics (called Faust pharmaceutical

study the regulation and protein-protein interactions of GPCRs and a small family of accessory proteins called

A call to Sanofi produced a compound from a drawer, the experiment worked, and the pharmacological chaperone active receptor - to a mixed audience of pharmacologists and chemists, the pharmacologists wanted to call The chemists called it allosteric regulation and asked what was new. 04:44 A father's death at 39 from hypertension and the path toward receptor pharmacology 08:18 Cold-calling In this episode, you will hear us talk about it.

Running multiple libraries in parallel moves the effective diversity toward 10¹² — the idea Aaron calls because the biology is easier, but because new technology is rewarded most where the incumbents have stalled

Bottlenecks in Your GPCR Pipeline ❌ Overwhelming pharmacology Data ❌ Suboptimal CRO Partnerships ❌ Stalled Let's Talk Discovery What Partners Say Here’s what it’s like to work together — from people I’ve supported Book Book My 30 Minutes Strategy Call Menu Home Services About News Ready to collaborate? Let’s talk about how I support GPCR discovery, pharmacology strategy, and cross-functional execution GPCR Calendly ©2023-2025 All rights reserved by FindYooour, LLC & Dr.

His numerous awards include: 2008 Sato Award; 2009 Medicinal Chemistry Hall of Fame (American Chemical

This research has led to a first-author Cell article on the development of a new biosensor platform called

His team also works on so-called non-canonical GPCRs — receptors once dismissed as non-functional because Cell context, assay choice, and receptor conformational heterogeneity all contribute to outcomes. intrabody raised against the active conformation of beta-arrestin-1 bound to the vasopressin receptor tail

At the height of curiosity, a seemingly naïve idea at the dinner table led to a side project by which

I was part of a study that identified the receptors of a novel human gut microbe-derived metabolite called most ubiquitous class of plasma membrane receptors and serve as targets for more than one-third of all prescribed drugs currently used in the treatment of human diseases all over the world.

signaling is not a GPCR-specific phenomenon but an evolutionarily conserved principle present across all it wrong, he called his graduate advisor. The advice he received - that if all controls have been run appropriately and the result still holds, What pharmacologists bring to drug discovery that nobody else does SELECTED QUOTES "If you've done all controls appropriately, and you've done the experiments to the best of your ability, and you've asked all

Sakmar recounts how a fateful phone call from Bruce Merrifield decades ago inspired his lifelong focus If you’re working on GPCRs, this is your call to leverage these tools , ask new questions, and help unlock

Yamina Berchiche: Why don't we start by you introducing yourself and telling us about what you're working Yamina Berchiche: Let’s talk about your PhD project. What was the core idea behind your research? Some papers call them hybrid receptors, others call them chimeric receptors, and sometimes they’re just We eventually created a publicly available database called GPCR ChimeraDB , which collects known hybrid