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extracellular domain, which contains the hormone-binding site and is linked to the transmembrane domain by the hinge

HLGR2 RNAi led to a low pupation rate (45.00%), body malformation, abnormal wing expansion, failed cuticle Conclusion: HLGR2 is essential for the growth and development and wing expansion and maturation in H.

  (3) Fan, J.; Toth, I.; Stephenson, R. J.

Welcome back GPCR fans, If your drug discovery strategy still relies on static GPCR models, you’re already

Welcome GPCR Fans,   In GPCR-targeted drug discovery, precision isn’t optional—it’s a requirement.

Graeme Milligan for receiving the Order of British Empire from King Charles III in recognition of his Graeme Milligan was awarded the Order of British Empire by King Charles III for services to Biochemical

Lu GPCR-BSD: a database of binding sites of human G-protein coupled receptors under diverse states Fan

Hey GPCR Fans, This week's breakthroughs are crucial for staying ahead in the rapidly evolving landscape

Welcome GPCR Fans,   Every discovery-phase decision you make shapes your entire pipeline trajectory—and

Welcome back GPCR fans, The pace of GPCR innovation is accelerating at a rate that can be difficult to

HH controls SMO subcellular localization and activity in a polarized epithelium using the Drosophila wing

Join our fantastic tribe today by becoming a DrGPCR Premium Member ! GPCR community members Build connections with other GPCR fans :) So much more to come!

GPCR community members Join the GPCR fan club and geek out with fellows! So much more to come!

We have explored hydrophobic groups of different sizes on both sides of the five-membered ring scaffold

Mariachi song: I typically do not sing to these since they are dear to Mexican childhood memories, and Don’t be surprised if you find yourself singing Daddy Yankee’s “Gasolina” from the top of your lungs

besides changing the chemical structure of the ligand, as it is generally introduced into aromatic rings

New Tools for Getting Drugs Inside Cells All of this hinges on a simple question: can your compound get

data into insights for drug discovery Hi GPCR Friends, Every week, critical decisions in GPCR research hinge

and dynamics simulation studies GPCRs in Neuroscience Neuronal cell populations in circumoral nerve ring

The Neuromedin U system: pharmacological implications for the treatment of obesity and binge eating behavior

A rational drug discovery campaign hinges on a deep understanding of how distinct molecules interact

Morgan Healthcare Conference Andrew Hopkins appointed CBE by HM King Charles III Voyager Therapeutics

Secure Your Spot for the October 30 AMA Why Terry’s Corner The efficiency of your pipeline doesn’t hinge

C., Ring, A.

Ping, Y.-Q., et al., Structural basis for the tethered peptide activation of adhesion GPCRs.

the observed phenotype since many glycosyltransferases and the two TPSTs also carry O-glycosylation (King

states: methods and implications The formation of functional complexes involving GPCRs and β-arrestins hinges

All of the talks were fantastic, but Maria would love to highlight these three: -            First, Prof

Hi GPCR Fanatics,   This week’s insights will help you avoid wasted time, poor forecasts, and stalled

intermediate recognition site between CRS1 and CRS2, first described in the CXCR4-vCCL2 structure (Qin