Venetia Zachariou  introduced him to the power of RGS proteins — particularly RGS4  — in modulating pain RGS4 and the Unexpected Recovery Phenomenon One of the most compelling findings in Serafini’s experience was the spontaneous recovery observed in RGS4 knockout mice . mouse was starting to enter what we consider the chronic pain range, the mice that were constitutively RGS4 Serafini noted that RGS4 was especially intriguing because it was expressed robustly both in the peripheral

Another signaling pathway related to RGS4 involves the regulation of the immune response. RGS4 is expressed in various immune cells, including T cells and B cells, and has been shown to modulate RGS4 acts as a negative regulator of T cell activation, and its expression is upregulated in response Traynor, Differential modulation of mu- and delta-opioid receptor agonists by endogenous RGS4 protein Avrampou, K., et al., RGS4 Maintains Chronic Pain Symptoms in Rodent Models.

protein-coupled receptor regulates ischaemia-reperfusion injury GPCRs in Cardiology, Endocrinology, and Taste RGS4

Here, we sought to investigate the role of Regulator of G Protein Signaling 7 (RGS7) in hyperlipidemia-dependent

Regulator of G-Protein Signalling 4 (RGS4) negatively modulates nociceptin/orphanin FQ opioid receptor

Whether RGS2 and 5 redundantly control G protein signaling to maintain cardiovascular homeostasis is Here we examined how the dual absence of RGS2 and 5 (Rgs2/5 dbKO) affects blood pressure and cardiac

and PM-restricted αqQ209L, resulting in increased binding to βγ and decreased binding to regulator RGS2

control synaptic glutamate time course at hippocampal CA1 synapses Regulator of G protein signaling 6 (RGS6

Must-read publications:  From on stabilizing RGS2 via modulating its degradation (versus direct inhibition

A case for (mutant) G protein-coupled receptors Reviews, GPCRs, and more RGS2 and female common diseases

Strategy through Molecular Modeling Studies and Biological Assays GPCRs in Oncology and Immunology RGS5

quantitation of Gαolf expression and signaling in murine brain tissue Regulator of G protein signaling 6 (RGS6