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Shane Wright, Michel Bouvier, et al., for their work on Conformation- and activation-based BRET sensors

Maria Majellaro’s story, shared in Episode 168 of the Dr.

& GPR3 regulated by a negative allosteric modulator Terry's Corner – Determine GPCR MoA Early (and Right Those acting on the right signals today will shape tomorrow’s breakthroughs—and avoid delays others won

Funding models rewarded independence, not shared resources. Michelle was part of a cohort that joined as postgrads in shared facilities, pooling reagents, ideas, A shared environment lowers friction between these specialties, making innovation structurally inevitable The Monash model flipped that logic: Shared infrastructure, not duplicated equipment Centralized core Shared funding gave us leverage.

Clark, Paul Ehrlich, Sir James Black, and more—sharing the stories and setbacks that shaped today’s scientific

🧠Do you want to share your #GPCR knowledge? Come to Dr.

June 2022 "Ottawa, Canada, May 10, 2022 — Orion Biotechnology Canada Ltd, a drug discovery and development company unlocking the therapeutic potential of G Protein-Coupled Receptors (GPCRs), today announced that it will be presenting important new data at both LSX World Congress and TIDES USA 2022 conference, taking place this week – May 10-12, 2022. Dr. Oliver Hartley, Orion’s Vice-President Drug Discovery, will present Orion’s novel technology for targeting undrugged peptidergic GPCRs. His presentations will describe Orion’s drug discovery platform, one of the fastest drug discovery solutions in the industry for targeting peptidergic GPCRs. Dr. Hartley will also present new data on Orion’s CCR2 antagonist, OB-004, demonstrating the ability of this powerful platform to rapidly identify best-in-class GPCR drug candidates." Read more at the source #DrGPCR #GPCR #IndustryNews

Latrophilin-1 drives neuron morphogenesis and shapes chemo- and mechanosensation-dependent behavior in

If you need a plasmid for your research or you want to share your materials, this is the place to go.

This week, you will learn how to confirm equilibrium the right way, detect time-dependent occupancy and Learn how to choose fluorophores (brightness, stability, spectra), reduce background (far-red/near-IR Scale confidently:  Use bright, stable ligands for HTS and bias profiling. across nanodiscs, peptidiscs, SMALPs, SPR, ITC—plus how construct design and solubilization choices shape Those acting on the right signals today will shape tomorrow’s breakthroughs—and avoid delays others won

This week’s edition links ligand mechanism to the decisions that shape affinity, efficacy, selectivity pharmacology essentials to ligand binding site strategies, bench-ready tools, and industry momentum shaping “You’re changing how bright it is—and how long it glows.” tool  can be just as critical as the right target . Acting on the right signals today shapes tomorrow’s breakthroughs—and avoids slowdowns others won’t see

Choosing the Right Lab The lab you choose plays a pivotal role in shaping your PhD journey. However, with multiple great options, choosing the right lab wasn't easy. The right environment, paired with a supportive supervisor, laid the foundation for a fulfilling and The Role of Mentors and Supervisors Having the right mentor is indispensable for a successful PhD journey Supervisors not only guide your research but also shape your academic and professional growth.

These probes shift brightness and fluorescence lifetime as pH changes. They learned how to fine-tune both brightness and fluorescence lifetime. You’re just changing how bright it is—and how long it glows,” said Dr. Eric Trinquet. They constructed the platform, tested every variable—pKa, brightness, lifetime—and made decisions that “You start wide with chemistry, you narrow with biology, and at the end—if you did it right—you open

teams and scientists, staying ahead requires more than just reading papers—it demands access to the right the future of GPCR research and drug discovery right now. Amplify your research:  Contribute to a high-impact collection of work that will shape the future of The right information at the right time can mean the difference between a breakthrough and a dead end Those acting on the right signals today will shape tomorrow’s breakthroughs—and avoid delays others won

Breakthroughs this week:  Orphan receptor GPRC5B in neurogenesis; Septerna’s pill-based weight-loss strategy Upcoming events:  Global GPCR summits and pharmacology forums shaping 2026 priorities. And that matter shapes everything: selectivity, safety, efficacy, and innovation. She explains why. • Training Builds Innovation : Her lab model at Monash is shaping the next generation Those acting on the right signals today will shape tomorrow’s breakthroughs—and avoid delays others won

For the serotonin 5-HT2A receptor (5-HT2AR) with the Gαi/o family of transducers, Wright and colleagues narrowed the activation of Gαi/o protein subtypes from all except Gαi1 to only Gαz in a recent study by Wright Wright and colleagues [36] showed that these heterotrimer-based biosensors for the 5-HT7A/B receptors 5-HT2A receptor (5-HT2AR), and (C) muscarinic acetylcholine M3 receptor (M3R) in a recent study by Wright Wright SC, Avet C, Gaitonde SA, Muneta-Arrate I, Le Gouill C, Hogue M, et al.

When David later shared early data — including a moment where he realized he could image an entire islet It would later shape how he designed fluorescent probes, how he evaluated biological constraints, and Early images showed clean, bright labeling across whole pancreatic islets. milestone that demonstrated just how powerful well-engineered chemical tools can be when paired with the right by trust, shared energy, and a willingness to learn each other’s language.

Imagine you're navigating a vast terrain—not on foot, but through the shape-shifting world of GPCRs. With the right lens, you’ll see why efficacy is more than signal strength: it's a fingerprint of conformational

This week, Terry’s Corner takes you beyond curve shapes into the kinetic and mechanistic realities that lipid droplets; novel atypical GPCR-arrestin complexes; Lilly's oral GLP-1, orforglipron, delivers weight Gain a competitive edge by asking the right questions about binding kinetics and experimental constraints Those acting on the right signals today will shape tomorrow’s breakthroughs—and avoid delays others won Join the community of informed, empowered GPCR professionals who are shaping the future of drug discovery

GPCR , we’re focusing on the hidden risks that undermine progress and how the right frameworks can keep To Terry's Corner ➤ Why the Myth of Multiple Affinity Sites Slows You Down Traditional models that shaped At this international meeting, leaders shared next-gen strategies shaping modern drug discovery: Prof GPCR Premium is designed for scientists who need the right intelligence, fast—without noise, distractions Those acting on the right insights now will define the next wave of discovery.

Why Misreading Antagonism Delays GPCR Drug Discovery If a dose-response curve shifts to the right, you In other words, you can’t diagnose mechanism from curve shape alone . DR curves shift to the right with no loss of maximal effect. He challenges the idea that curve shape alone is diagnostic, pointing out how features like receptor One shifts neatly to the right without dropping the maximum.

Hello GPCR Innovators ,   We’re preparing to launch Terry’s Corner, a new knowledge hub shaped by Dr. Novo Nordisk’s amycretin showed up to 24% weight loss, CagriSema delivered 22.7% in Phase 3, and semaglutide Maria Majellaro shares her story of innovation and listening-driven science.  

GPCR, it was with a simple goal: to connect people who shared a passion for GPCR science and discovery directly to the researchers who use them , empowering scientists to move their work forward with the right Our Ambassador Program empowers community members to share Dr. We’ll share how to apply — and the details — soon. Community and Connection Dr. helps shape what comes next for Dr.

With the right tools, bold ideas, and powerful collaborations, you’re not just keeping pace. You’re actively shaping what’s next.

Kevin Wright on his new position as Director of Targeted and Immuno-oncology at GPCR Therapeutics, our Kevin Wright Joins GPCR Therapeutics as Director of Targeted and Immuno-oncology Sosei Heptares Adds

The Log(IC50) change in time was fitted with equation  3  and k given is the weighted average from 3  (A)  or 4  (B)  experiments with weighted SD The Ki values were calculated based on the IC50 values, Fluorescence and bright-field images of total (left panels) and non-specific binding (central panels) of CELT-419 to live HEK293-D3R cells and to SKOV3 cells without D3 receptors (right panels). The contrast of fluorescence and bright-field images was enhanced for presentation purposes only, the

Assay sensitivity is like adjusting the brightness on a microscope—set it right, and hidden details jump What emerges is not just more data—it’s the right data, positioned to inform strategic decision-making

Without the right model, it’s like staring at identical twins—you can’t tell them apart until you see With the right model, you can separate lookalikes and prevent an entire program from being misclassified Here’s the uncomfortable truth: you can never prove a model “right.” They need the right data . Only when the data were fit to the right model did the picture snap into focus.

In this podcast, he lays out the mindset that helped shape products used across biotech and academia—and Originally developed as ultra-bright lanthanide probes, the team realized they could tune these molecules Dual control: not just brightness but fluorescence lifetime, with drastic shifts as pH drops. It’s a mindset shaped by decades in the lab—but it’s also a warning.

Ready for your GPCR quest, so bold and bright? Join us now, and let's explore with all our might! Let's make your brand shine like never before! in Neuroscience Ventral tegmental area amylin / calcitonin receptor signaling suppresses feeding and weight