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Thomas P. Sakmar on how the molecular studies of rhodopsin paved the way to understanding #GPCRs Be sure to subscribe

November 2021 "So proud and grateful to receive honorary doctorate yesterday from Karolinska Institute and celebrate with my family in Stockholm." Read more at the source #DrGPCR #GPCR #IndustryNews

This Week’s Highlights: Celebrating Excellence: Hyoungjun Ham , Yamina Berchiche , Thomas Sakmar , Vladimir mutations in a G protein identify signaling cross-talk in T cells Victoria Saca , Colin Burdette , and Thomas Sakmar for their excellent study on GPCR Biosensors to Study Conformational Dynamics and Signaling

for their work on GPCR gene variants and human genetic disease Ilana Kotliar , Thomas Sakmar , et al.

Tom Sakmar points to a largely overlooked mechanism  in disease: autoantibodies that don’t block receptors A New Role for GPCRs in Disease Sakmar highlights how endothelial cells, which express a wide array of “Some of these antibodies actually activate the receptor and cause pathological signaling.” — Tom Sakmar Sakmar and Kotliar’s system is multiplexed and scalable , able to test hundreds of interactions from

Tom Sakmar didn’t set out to map GPCR-RAMP interactions across hundreds of receptors. In fact, it all began with a phone call (from Bruce Merrifield, no less) encouraging Sakmar to work on A Long-Term Obsession, Reframed Sakmar’s lab had been focused on the secretin receptor family  for decades “The beauty of multiplexing is that you can do many things with one pot of samples.” — Tom Sakmar Enter

Sakmar reflects on a generational shift in training. Building for the Future The Sakmar lab built a system to meet that need: Dual-epitope tagged constructs This delivers all three.” — Tom Sakmar A Use Case for Every Angle Beyond RAMPs, this platform can study

Explore the partnership Multiplexing GPCR Discovery - Sakmar Lab’s Toolkit Goes Public The latest podcast Tom Sakmar, Emily Lorenzen, and Ilana Kotliar about creating a multiplex system with DUET-tagged constructs

Bryan Roth, Peter Gmeiner, and Thomas P. Sakmar this week. For Dr.

Thomas P. Sakmar and his team used 'bioluminescence resonance energy transfer to measure cell-surface expression

Thomas P. Sakmar, Debbie L. Hay, Lukas Grätz, and more.

Tom Sakmar and Dr.

-A., Thomas, T., Nguyen, T. D., Muñoz, L. L., Gregory, K. J., White, P. J., Sexton, P.

contributor article Canonical chemokine receptors as scavenging “decoys” Shivani Sachdev, Brendan Creemer, Thomas

Thomas Südhof, but did not start working on them right away.

phosphosulfate (PAPS) donor to the hydroxyl group of a tyrosine residue of the protein chain (Seibert C and Sakmar

towards previously established chemical space, limiting their ability to identify truly novel chemotypes”(Thomas

Aylin Hanyaloglu, Caroline Gorvin, and Alejandra Tomas.

Alejandra Tomas, et al. for their research on Engineered mini-G proteins block the internalization of

ß-arrestin functional specificity at C-X-C chemokine receptor 5 (CXCR5) Panjamaporn Sangwung , Alejandra Tomas

Alejandra Tomas, et al. for their study on Lipid regulation of the glucagon receptor family Drs.