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It turns out that it was signal transduction, and he worked on the signaling cascades involved in heart His encounter and interest in signaling in the context of GPCRs during his postdoctoral training in Dr Today, John and his team focus on understanding how signal transduction cascades downstream of the opioid receptors work, including the unique organization of chaperone protein Hsp90 modulation of opioid signaling

Committee Sponsors GPCR Retreat Program < Back to schedule Regulation and role of mitochondria delta opioid pharmacology and has published seminal papers where he used various approaches to describe the role of opioid pain and anagesia as well as to study the mechanisms involved in the cellular trafficking of the delta opioid

Paul Clarck , where she studied opioid receptors. She then returned to academia and worked on opioids as a postdoctoral trainee with Dr. Brigitte Kieffer , where she studied ligand-directed signaling at the delta-opioid receptor. Amynah studied how arrestins regulate ligand-directed signaling at delta-opioid receptors, and it is Andrew Charles that who specialized in animal models of migraine and delta-opioid receptors as a therapeutic

Postdoc with Graeme Henderson (Bristol, opioids and Ca signaling) and Mac Christie (Sydney, opioids in Grant-funded independent research positions from 2001 at University of Sydney (opioids and sensory neurons visiting scientist with Ed McCleskey, sensory neuron properties); Pain Management Research Institute (more opioids Focus on study of drugs and toxins on GPCR (opioid, cannabinoid receptor) and ion channel (K, Ca, TRP

Catherine Demery shares how she found clarity and purpose in academic opioid research. Fentanyl and xylazine are pushing the opioid crisis into dangerous new territory, and Catherine Demery Her research combines cutting-edge GPCR signaling studies with real-time public health data from Michigan Why This Matters Fentanyl : Potent synthetic opioid that decreases inhalation rate. Why xylazine is an emerging overdose threat and how it differs mechanistically from opioids.

Graciela has done extensive work on the molecular pharmacology of opioid receptors, exploring their signaling , trafficking, and their ability to activate different signaling pathways and signaling bias.

the regulation of axonal transport by tricyclic antidepressants (M.Sc.) and molecular pharmacology of opioid The Tiberi Lab pursues the study of the molecular, structural, pharmacological and signaling features More specifically, we investigate the druggability potential of new signaling partners we identified

My interests in research are primarily directed towards methods that study GPCRs and GPCR signaling, In my current research project I use iPSC-derived cardiac fibroblasts to examine cellular signaling in GPCR Title: Characterization of Novel Opioid-Neurotensin Bifunctional Ligands Designed to Target Pain protein-coupled receptors (GPCRs) ligands for the treatment of chronic pain but also in deciphering cellular signaling Synapse-Associated Protein 102 and Post-Synaptic Density 95 Differentially Shape Dopamine D1 Receptor Signaling

pain pathway What it means to “teach AI protein dynamics,” and how Superluminal is using it to predict signaling /PhD, a rejection letter pivoted him into a PhD program at the University of Iowa, where he studied opioid Driven by the opioid crisis and the lack of non-addictive pain treatments, Ajay co-founded Blue Therapeutics company using machine learning to explore GPCR structure-function relationships and predict biased signaling

GPCR scientist Ben Clements shares how positive allosteric modulators could transform opioid therapy GPCRs and the Opioid Crisis: A New Pharmacological Frontier Now at the University of Michigan, Ben focuses on positive allosteric modulators (PAMs) targeting opioid receptors. “We’re enhancing the powerful pain-relieving effects of opioids while limiting respiratory depression uses in vitro and in vivo models to discover and characterize novel treatments for chronic pain and opioid

Sudarshan Rajagopal Ligand-biased signalling and location bias; two faces of functional selectivity Dr Polina Isaikina Gz-Enhanced Signal Transduction assaY (GzESTY) for GPCR deorphanization Dr. Cesare Orlandi Accurate Mechanistic Calculation of μ Opioid Receptor Signaling Efficacy - Poster Presentation Being able to pause and re-watch complex presentations on signaling pathways has been crucial for advancing

These ligands stimulate receptor β-arrestin recruitment without activating canonical G protein signaling Because BAMs engage less well-conserved allosteric sites and exert pathway-specific effects on receptor signaling , they are exciting tools for linking distinct signaling pathways with their physiological effects and selectivity can be leveraged in the development of safe and effective treatments for stimulant and opioid

He has been also studying what aspects of GPCR signaling are regulated in a sex-selective manner and Thomas Sakmar’s laboratory at The Rockefeller University, where she study’s the signaling and degradation She is currently working to understand the signaling and degradation of GPCRs in disease states to help lab where she helped to investigate the role of various ATP-sensitive potassium channels in pain and opioid

Terry Kenakin ’s hands-on workshop, The Practical Assessment of Signaling Bias . Didn’t sign up? Highlights of the Week How Ligands Achieve Biased Signaling toward Arrestins Stéphanie Gaillard , Neha obesity drug discovery: Cell-based assays for GLP-1 and the G-Suite March 17 - 21, 2025 | 2nd GPCR signaling Principal Scientist, Medicinal Chemistry PhD fellowship in GPCR mechanosensing GPCR Activation and Signaling g , MC4R , docking , opioid , peptide ligand design , protein design , Ca2+ oscillation , GPCRs , basal

She has done extensive work on the molecular pharmacology of opioid receptors and is currently focusing

These ligands stimulate receptor β-arrestin recruitment without activating canonical G protein signaling Because BAMs engage less well-conserved allosteric sites and exert pathway-specific effects on receptor signaling , they are exciting tools for linking distinct signaling pathways with their physiological effects and selectivity can be leveraged in the development of safe and effective treatments for stimulant and opioid

John Traynor , Kathryn worked to develop and understand first-in-class allosteric modulators of opioid

Back to Full Agenda Session I Tethered agonist - dependent/independent activation mechanism in AGPCRs Signaling Region with Transmembrane Domain in a Holo-Adhesion GPCR Demet Araç Heterogeneity of Tethered Agonist Signaling It has been suggested that the TA can regulate receptor signaling without coming out of the GAIN domain The TA peptide remains at its original position and is not involved in signaling. As an undergraduate, he studied opioid receptor trafficking and G protein conformational dynamics in

Whether you’re decoding signaling pathways or designing the next generation of therapeutics, Revvity it doesn't emit a strong signal when bound to the surface. TRF detection, which effectively filters out short-lived background signals. pathway, from ligand binding and G-protein activation to intracellular signaling readouts. All four formats are validated in well-established models like GLP1R and Mu opioid receptor (MOR), and

Registration Logo Contest Committee Sponsors GPCR Retreat Program < Back to schedule Targeting adenosine signaling for immuno-oncology Date & Time Friday, November 3rd / 4:35 PM Abstract "Adenosine (ADO) signaling through Potent inhibitors of ADO signaling are currently being tested in cancer patients, including in randomized I will present our recent work on adenosine-producing ectonucleotidases and adenosine signaling and discuss

"I wasn't able to get stronger pain meds because of the opioid epidemic," he recalls. Serafini found himself repeatedly drawn to them, or more precisely, to RGS (Regulators of G protein Signaling him to BSL-3 labs to study persistent pain after SARS-CoV-2 infection, revealing novel immune-neuron signaling

Sponsors GPCR Retreat Program < Back to schedule Biochemical Mechanisms Underlying Location Bias in GPCR Signaling His lab is also interested in identifying novel signal transduction mechanisms of GPCRs, such as the

Committee Sponsors GPCR Retreat Program < Back to schedule Unveiling Non-Canonical Functions for Gαq Signaling During this period and her doctoral thesis, she has deepened the regulatory mechanisms of GPCR signaling characterization of proteins that act at the level of G proteins and which are part of a multimolecular signaling complex (AGS, de “Activators of G-protein signaling). Ribas has characterized the existence of a new signaling pathway with a relevant role in cardiac hypertrophy

The Practical Assessment of Signaling Bias Dr. Terry Kenakin < Back Workshop Summary Join Dr. Terry Kenakin , a leading expert in pharmacology, as he unpacks the fascinating world of signaling bias how different ligands (compounds) can stabilize unique receptor conformations, leading to distinct signaling Key Highlights 🔍 Bias is Everywhere : Signaling bias naturally occurs in pharmacology—whether we look This allows for a side-by-side comparison of how different compounds influence receptor signaling. 📌

Contest Committee Sponsors GPCR Retreat Program < Back to schedule Using food perception and bioamine signaling laboratory focuses on how organisms perceive and respond to environmental stress though cell non autonomous signaling mechanisms, and how these signals affect the health and longevity of the animal."

Registration Logo Contest Committee Sponsors GPCR Retreat Program < Back to schedule Distinct sub-cellular signal Since 2001, he holds the Canada Research Chair in Signal Transduction and Molecular Pharmacology. He is a world-renowned expert in the field of cell signaling and GPCRs and made seminal contributions In addition to paradigm shifts including inverse agonism, biased signaling, and pharmacological chaperones

. << Back to podcast list Strategic Partner(s) How Lipid Rafts Organize GPCR Signaling This episode features database and reviews key findings from his research on D1 receptor desensitization and GRK isoform signaling Why This Matters How lipid raft microdomains selectively regulate GPCR signaling and internalization protein-coupled receptors and D1 receptor regulation—work that sparked his ongoing engagement with receptor signaling

Retreat Program < Back to schedule Interaction with the cell adhesion molecule NEGR1 affects mGluR5 cell signalling

Contest Committee Sponsors GPCR Retreat Program < Back to schedule Inhibition of Relaxin Autocrine Signaling Rottapel’s research interests lies in the elucidation of signal transduction pathways in cancer, immune

Michelle Halls reveals how organized GPCR signaling drives assay innovation and new therapeutic insights . << Back to podcast list Strategic Partner(s) Leadership, Impact, and GPCR Signaling with Dr. Michelle Halls shares how dissecting the spatial organization of GPCR signaling opens new doors in drug From early discoveries in cyclic AMP signaling to uncovering ultrasensitive receptor responses at femtomolar localized signaling events, how these mechanisms are hijacked in disease, and how they can be leveraged