Search Results

It's a great opportunity to get warmed up for the upcoming Summit starting the next Monday.

selectively targeting CB2 receptors with respect to schizophrenia, the studies discussed below could suggest

Promising preclinical data support the applicability of CB2 activation in autoimmune and inflammatory

calcium-permeable cation channel TRPM3 can be activated by heat and the endogenous steroid pregnenolone sulfate

Here we review the current knowledge regarding the molecular details of psychedelic drug actions and suggest

Emerging evidence suggests adenosine G protein-coupled receptors (GPCRs) are promising therapeutic targets In this review, we provide an accessible summary of the literature on Alzheimer's disease and the therapeutic strategies, including allosterism and the targeting of oligomers, which may increase drug discovery success

These data support the premise that GRK2 should be at the forefront of a novel investigative drug search GPCRs, describes the structure and functions of GRK2 in cardiac function and maladaptive pathology, and summarizes

Here, this review summarizes different PTMs in GPCR internalization and analyzes their significance in

Our analysis suggests that the structures of GPCRs bound to these interaction partners available today there are no generalizable GPCR conformations conducive to binding a particular type of partner; (ii) subtle

In summary, a potent and selective APJ agonist suitable for in vivo studies of APJ in peripheral tissues

tetramethylrhodamine (TAMRA)-labeled CCR2 ligands were designed, synthesized, and tested for their suitability

showed that activation of Gq/11 proteins by G-protein coupled receptors has pro-nociceptive properties, suggesting

application to cell-based kinetic studies "G protein-coupled receptors (GPCRs) are an important receptor superfamily As well, the GloSensor-22F biosensor had a superior signal-to-background ratio and the effect of temperature

This paradox solicits urgent attention to find a suitable justification for disturbed neurotransmission

Genetic variants in ITGA9, which encodes the α9 subunit of integrin α9β1, and SVEP1, a ligand for integrin

This review summarizes the roles of GRK2/β-arrestin2 in immune cell function and focuses on the pathological

Synaptamide suppressed osteoclastogenesis induced by receptor activator of nuclear factor-kappa B ligand But GPR110 knockout and subsequent rescue experiments revealed a pivotal role of GPR110 in the attenuation These results suggest that synaptamide/GPR110 signaling negatively regulates osteoclastogenesis. Our study suggested that ligands of GPR110, such as synaptamide, might be a useful drug for osteoporotic

August 2022 "Chemokines, a subgroup of cytokines along with their receptors, are involved in various of SDF-1 to CXCR4 initiates several intracellular signaling pathways, regulating cell proliferation, survival

August 2022 "GPR21 is an orphan and constitutively active receptor belonging to the superfamily of G-Protein

protein-coupled receptors (adhesion GPCRs), as a member of the G protein-coupled receptors (GPCRs) superfamily

August 2022 "Histamine exerts its physiological functions through its four receptor subtypes. In this work, we report the subcellular localization of histamine receptor 2 (H2R), a G protein-coupled

An analysis of mutual interactions of subunits in the C5aR1-G protein complex has provided new insights details of local and global changes in the transmembrane domain induced by interactions with the Gα subunit

August 2022 "G-protein-coupled receptors (GPCR) are present at the cell surface in different conformational used TIRF microscopy and a statistical method to track and classify the motion of different receptor subpopulations We showed a diversity of ligand-free forms of CCR5 at the cell surface constituted of various oligomeric These results suggest a link between receptor activation and immobilization.

Molecular dynamics simulations support the local conformational flexibilities and different stabilities

GPCR crystallography, inserting a fusion protein between transmembrane helices 5 and 6 is a highly successful determination of GPCRs alone without signaling protein, the critical determinants that make this approach successful

HTR1E stable cells with NF-α1/CPE increased pERK 1/2 and pCREB levels which prevented a decrease in pro-survival Cell survival assay in β-arrestin Knockout HEK293 cells showed that the NF-α1/CPE-5-HTR1E-mediated protection Immunofluorescence studies showed 5-HTR1E and NF-α1/CPE are highly expressed and co-localized on cell surface

GRK2 was shown to be expressed in human neutrophils and analysis of subcellular fractions revealed a

August 2022 "Emerging evidence suggests that G protein-coupled receptor (GPCR) kinases (GRKs) are associated Here, we determine that GRKs phosphorylate a non-canonical substrate, anterior pharynx-defective 1A (

Rho1 signaling is activated by G-protein-coupled receptor (GPCR) signaling at the cell surface. Our data support a model wherein Smog regulates distinct myosin pools and actin cytoskeleton in a ligand-dependent

glutathione-S-transferase) and analysis of the N267K mutation in the fibronectin type III domain 1 (FnIII.1) suggest Our data support the idea of a modulatory role of anosmin 1 in the biological effects controlled by the