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Results found for "GPCR webinar series"
- Pharmacological Properties and Function of PxOctβ3 Octopamine Receptor in Plutella xylostella (L.)
A series of octopamine receptor agonists and antagonists were tested against PxOctβ3. showed that the receptor is a member of the Octβ3 protein family, and an analysis using quantitative PCR Read more at the source #DrGPCR #GPCR #IndustryNews
- Odorant receptors – a bit of smell for drug discovery
function and expression landscape Odorant receptors (ORs) belong to the G protein-coupled receptor (GPCR OR51E1 and OR51E2, initially assumed to be GPCRs only expressed in prostate tissue, play a role in prostate compounds, there has been a growing interest from the scientific community to target this class of GPCRs expression of ORs is generally more technically challenging compared with expression of nonolfactory GPCRs Check the original article at https://pubmed.ncbi.nlm.nih.gov/35999088/ #GPCR #DrGPCR#Ecosystem
- Expression pattern and clinical significance of beta 2-adrenergic receptor in oral squamous cell...
Methods: Immunohistochemistry, western blot and quantitative real-time PCR techniques were used to analyze Read more at the source #DrGPCR #GPCR #IndustryNews
- Anosmin 1 N-terminal domains modulate prokineticin receptor 2 activation by prokineticin 2
Prokineticins (PKs) exert their biological functions through the activation of the G protein-coupled receptors (GPCRs Read more at the source #DrGPCR #GPCR #IndustryNews
- Enhanced membrane binding of oncogenic G protein αqQ209L confers resistance to inhibitor YM-254890
October 2022 "Heterotrimeric G proteins couple activated G protein-coupled receptors (GPCR) to intracellular They can also function independently of GPCR activation upon acquiring mutations that prevent GTPase YM-254890 (YM) can inhibit signaling by both GPCR-activated wild type αq and GPCR-independent αqQ209L GPCR-dependent signaling by PM-restricted wild type αq is strongly inhibited by YM, demonstrating that Read more at the source #DrGPCR #GPCR #IndustryNews
- GPCRS: AN ODYSSEY FROM STRUCTURE, SIGNALING AND REGULATION TO THERAPEUTICS
09, 2022 | | SNOWBIRD RESORT, UTAH, UNITED STATES The superfamily of G protein-coupled receptors (GPCRs mechanisms of GPCR function has revealed new paradigms with increasingly complex models of receptor Spatial-temporal signaling of GPCRs and physiological functions; 2. GPCRs as environmental sensors; 3. New approaches to GPCR drug discovery.
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- Structures of oxysterol sensor EBI2/GPR183, a key regulator of the immune response
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- Cell Surface Calcium-Sensing Receptor Heterodimers: Mutant Gene Dosage Affects Ca 2+ Sensing but...
Protein Interaction "The calcium-sensing receptor is a homodimeric class C G protein-coupled receptor (GPCR Read more at the source #DrGPCR #GPCR #IndustryNews
- Roles of Focal Adhesion Kinase PTK2 and Integrin αIIbβ3 Signaling in Collagen- and GPVI-Dependent...
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- Mechanistic Understanding of the Palmitoylation of Go Protein in the Allosteric Regulation of...
Protein in the Allosteric Regulation of Adhesion Receptor GPR97 "Adhesion G-protein-coupled receptors (aGPCRs )-a major family of GPCRs-play critical roles in the regulation of tissue development and cancer progression The orphan receptor GPR97, activated by glucocorticoid stress hormones, is a prototypical aGPCR. of the Go protein, and offers guidance for future drug design of aGPCRs." Read more at the source #DrGPCR #GPCR #IndustryNews
- Endocannabinoid System in the Neuroendocrine Response to Lipopolysaccharide-induced Immune Challenge
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- All About Addgene: More Open and Reproducible Science with Materials Sharing
GPCR Virtual Cafe? Register today! Addgene's Dr. Joanne Kamens is our guest. research or you want to share your materials, this is the place to go. https://www.ecosystem.drgpcr.com/dr-gpcr-virtual-cafe / #gpcr #drgpcr #virtualcafe #addgene
- Neuropeptide S Encodes Stimulus Salience in the Paraventricular Thalamus
Read more at the source #DrGPCR #GPCR #IndustryNews
- To probe the activation mechanism of the Delta opioid receptor by an agonist ADL5859 started from...
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- A Setmelanotide-like Effect at MC4R Is Achieved by MC4R Dimer Separation
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- Reversible Photocontrol of Dopaminergic Transmission in Wild-Type Animals
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- Viral G Protein-Coupled Receptors Encoded by β- and γ-Herpesviruses
acquired genes are transmembrane proteins and cytokines, such as viral G protein-coupled receptors (vGPCRs This review focuses on the vGPCRs encoded by the human β- and γ-herpesviruses. These include receptors from human cytomegalovirus, which encodes four vGPCRs: US27, US28, UL33, and We discuss ligand binding, signaling, and structures of the vGPCRs in light of robust differences from Read more at the source #DrGPCR #GPCR #IndustryNews
- Orthosteric vs Allosteric Interactions— and the pHSense Shift in Internalization
GPCR Weekly News Free Edition—your clear, credible signal in a noisy field. GPCR Forum to Biophysics; plus targeted summits for discovery teams planning 2025–2026. GPCR members save 50%+ (check your Weekly News code). Speed: faster GPCR target validation and assay development. The pace of GPCR innovation is accelerating.
- Isoforms of GPR35 have distinct extracellular N-termini that allosterically modify...
and mediate intracellular pathway bias "Within the intestine, the human G protein-coupled receptor (GPCR Read more at the source #DrGPCR #GPCR #IndustryNews
- Genome-wide identification of 216 G protein-coupled receptor (GPCR) genes from the marine water ...
Genome-wide identification of 216 G protein-coupled receptor (GPCR) genes from the marine water flea Diaphanosoma celebensis G protein-coupled receptors (GPCRs) are considered to have originated from early evolution of eukaryotic species, therefore, the genome-wide identification of GPCR genes can provide Here, we identified a total 216 full-length GPCR genes in the marine water flea Diaphanosoma celebensis In this study, these results may provide a better understanding on the evolution of GPCRs, and expand
- Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin...
epithelial-cell-derived antimicrobial peptides defensins activated orphan G-protein-coupled receptors (GPCRs Read more at the source #DrGPCR #GPCR #IndustryNews
- CCL25/CCR9 interaction promotes the malignant behavior of salivary adenoid cystic carcinoma via...
Methods Immunohistochemistry staining and RT–qPCR analyses were performed to detect the correlation of Western blot and RT–qPCR assays were carried out to measure the downstream factors of the interaction Read more at the source #DrGPCR #GPCR #IndustryNews
- Angiotensin-(1-7) improves cognitive function and reduces inflammation in mice following mild trauma
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- Differential binding of Δ9-tetrahydrocannabinol derivatives to type 1 cannabinoid receptors (CB1)
Introduction Cannabinoid receptors are GPCRs, and two main types exist, CB1R and CB2R. Figure 2.Assay Principle: TR-FRET assay using CELT-335, a dual (CB1/CB2) fluorescent ligand that serves for CB1R in live cells and the PHERAstar FSX is the ideal microplate reader for characterizing the GPCR-ligand
- Pharmacophore-guided Virtual Screening to Identify New β 3 -adrenergic Receptor Agonists
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- The Impact of CB1 Receptor on Nuclear Receptors in Skeletal Muscle Cells
Quantitative real-time probe-based polymerase chain reaction (qRT-PCR) assays are deployed in order to This can be deduced from the qRT-PCR assays; triggering CB1 receptors amplifies both NR4A1 and NR4A3 Read more at the source #DrGPCR #GPCR #IndustryNews
- Dynamic recognition of naloxone, morphine and endomorphin1 in the same pocket of µ-opioid receptors
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- Actions of Parathyroid Hormone Ligand Analogues in Humanized PTH1R Knockin Mice
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