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Results found for "GPCR research community"
- Neuropeptide S Encodes Stimulus Salience in the Paraventricular Thalamus
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- To probe the activation mechanism of the Delta opioid receptor by an agonist ADL5859 started from...
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- A Setmelanotide-like Effect at MC4R Is Achieved by MC4R Dimer Separation
increasing numbers of people with excess body weight, the MC4R has become a target of interest in the search Read more at the source #DrGPCR #GPCR #IndustryNews
- Reversible Photocontrol of Dopaminergic Transmission in Wild-Type Animals
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- Viral G Protein-Coupled Receptors Encoded by β- and γ-Herpesviruses
acquired genes are transmembrane proteins and cytokines, such as viral G protein-coupled receptors (vGPCRs This review focuses on the vGPCRs encoded by the human β- and γ-herpesviruses. These include receptors from human cytomegalovirus, which encodes four vGPCRs: US27, US28, UL33, and We discuss ligand binding, signaling, and structures of the vGPCRs in light of robust differences from Read more at the source #DrGPCR #GPCR #IndustryNews
- Isoforms of GPR35 have distinct extracellular N-termini that allosterically modify...
and mediate intracellular pathway bias "Within the intestine, the human G protein-coupled receptor (GPCR Read more at the source #DrGPCR #GPCR #IndustryNews
- Genome-wide identification of 216 G protein-coupled receptor (GPCR) genes from the marine water ...
Genome-wide identification of 216 G protein-coupled receptor (GPCR) genes from the marine water flea Diaphanosoma celebensis G protein-coupled receptors (GPCRs) are considered to have originated from early evolution of eukaryotic species, therefore, the genome-wide identification of GPCR genes can provide Here, we identified a total 216 full-length GPCR genes in the marine water flea Diaphanosoma celebensis In this study, these results may provide a better understanding on the evolution of GPCRs, and expand
- Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin...
epithelial-cell-derived antimicrobial peptides defensins activated orphan G-protein-coupled receptors (GPCRs Read more at the source #DrGPCR #GPCR #IndustryNews
- CCL25/CCR9 interaction promotes the malignant behavior of salivary adenoid cystic carcinoma via...
Methods Immunohistochemistry staining and RT–qPCR analyses were performed to detect the correlation of Western blot and RT–qPCR assays were carried out to measure the downstream factors of the interaction Read more at the source #DrGPCR #GPCR #IndustryNews
- Angiotensin-(1-7) improves cognitive function and reduces inflammation in mice following mild trauma
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- Glyco-sulfo hotspots in the chemokine receptor system
Further research will be needed to boost our understanding on the dynamics and biological relevance of Check the original article at https://pubmed.ncbi.nlm.nih.gov/36729338/ #GPCR #DrGPCR#Ecosystem
- Pharmacophore-guided Virtual Screening to Identify New β 3 -adrenergic Receptor Agonists
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- Dynamic recognition of naloxone, morphine and endomorphin1 in the same pocket of µ-opioid receptors
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- Actions of Parathyroid Hormone Ligand Analogues in Humanized PTH1R Knockin Mice
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- Differences across sexes on head-twitch behavior and 5-HT2A receptor signaling in C57BL/6J mice
understanding of psychedelic pharmacology is derived from rodent models, but most of this preclinical research mice, and support the importance of studying sex as a biological variable in preclinical psychedelic research Read more at the source #DrGPCR #GPCR #IndustryNews
- A robust and Efficient FRET-Based Assay for Cannabinoid Receptor Ligands Discovery.
GPCRs are not suitable for antibody use due to steric hindrance and reverse binding, thus, other strategies This modification is small enough to not affect GPCR expression or activity.[21–23] The Tag-lite® binding It has been applied to different GPCR binding assays, such as CXCR4, opioid receptors, CCK1 and CCK2. Cannabinoids as Anticancer Drugs: Current Status of Preclinical Research. Nucleic Acids Research 2021 , 49 (12), e72–e72. https://doi.org/10.1093/nar/gkab237 . (20) Degorce
- Structural perspectives on the mechanism of signal activation, ligand selectivity and allosteric...
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- Structural dynamics of Smoothened (SMO) in ciliary membrane and its interaction with membrane lipids
September 2022 "The Smoothened receptor (SMO, a 7 pass transmembrane domain, Class F GPCR family protein Read more at the source #DrGPCR #GPCR #IndustryNews
- SYnAbs is now officially accredited as a Research Tax Credit by the French Ministry of Higher...
August 2022 "We are proud to announce that SYnAbs is now officially accredited as a Research Tax Credit by the French Ministry of Higher Education and Research for 2022-2023-2024. #technology #lifescience #immunology #antibodies #medicine #cancer #innovation #gpcr #synabs #monoclonalantibodies #drugdiscovery #biotechnology #research #ionchannels #biologics #biotech #pharma #pharmaindustry #pharmaceuticals #oncology #healthcare #drugdevelopment" Read more at the source #DrGPCR #GPCR #IndustryNews
- Design and validation of recombinant protein standards for quantitative Western blot analysis of...
antibody-antigen interaction-based approaches for quantitative analysis of G protein-coupled receptor (GPCR GPCRs in general and cannabinoid CB1 receptor in particular show a progressive tendency to aggregate This renders full-length recombinant GPCRs useless for analytical purposes, a problem that can be overcome Read more at the source #DrGPCR #GPCR #IndustryNews
- Mechanism of enhanced sensitivity of mutated β-adrenergic-like octopamine receptor to amitraz in...
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- GPR84 signaling promotes intestinal mucosal inflammation via enhancing NLRP3 inflammasome activation
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- Regulator of G Protein Signaling 20 Correlates with Long Intergenic Non-Coding RNA (lincRNAs)...
Interestingly, RGS (Regulators of G protein signaling) proteins, which negatively regulate GPCR signaling Read more at the source #DrGPCR #GPCR #IndustryNews
- Dopamine activates astrocytes in prefrontal cortex via α1-adrenergic receptors
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- Divergent roles for the gut intraepithelial lymphocyte GLP-1R in control of metabolism, microbiota..
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- Cell-Type-Specific Effects of the Ovarian Cancer G-Protein Coupled Receptor (OGR1) on Inflammation..
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- Integrative model of the FSH receptor reveals the structural role of the flexible hinge region
receptor (FSHR) belongs to the glycoprotein hormone receptors, a subfamily of G-protein-coupled receptors (GPCRs models are expected to allow for testable hypotheses about signal transduction and drug development for GPHRs Read more at the source #DrGPCR #GPCR #IndustryNews
- GPCRs Are Optimal Regulators of Complex Biological Systems and Orchestrate the Interface between ...
GPCRs Are Optimal Regulators of Complex Biological Systems and Orchestrate the Interface between Health and Disease GPCRs arguably represent the most effective current therapeutic targets for a plethora of GPCRs also possess a pivotal role in the regulation of the physiological balance between healthy and GPCRs have been long considered as controllers of communication between tissues and cells. This communication involves the ligand-mediated control of cell surface receptors that then direct their
- Irreversible Drugs, Real Control: Design for Durable Target Engagement
Upcoming events: Membrane-mimetic screening; GPCR Forum 2025; GPCR-TDD Summit Europe. Membership Gives You: Proven frameworks used in real discovery programs On-demand lessons built for tight research operating system for discovery decisions, featuring practical frameworks, trusted curations, and a community Become a Premium Member today. ➤ 🎓 Full GPCR University + 🔬 200+ expert talks 🗞️ Weekly research, field 🧠 Designed for researchers at every career stage
- Decoding β-Arrestins: from Structure to function
Fine-tuning GPCR signaling: conformational dynamics and intracellular responses GPCR signaling is a complex Apart from G proteins, GPCRs engage other effectors for signaling modulation. GPCR kinases (GRKs) and β-arrestins are activated by agonist-bound GPCRs and interact with the receptor Recent years have seen cryo-EM dominate new GPCR structure determinations, offering insight into GPCR-effector dissociation of crucial effector proteins within distinct subcellular locations remains a fundamental research
