Search Results
Results found for "Haoqing Wang"
- Feeder or trigger – CCR2 as a scavenger and regulator of cell migration
Wang et al. 2009; R. J.
- Overview of adhesion GPCRs self-activation
Qian, Y., Ma, Z., Liu, C., Li, X., Zhu, X., Wang, N., Xu, Z., Xia, R., Liang, J., Duan, Y., Yin, H.,
- Hear the sounds: the role of G protein-coupled receptors in the cochlea
G protein-coupled receptors (GPCRs) are crucial receptors that regulate a wide range of physiological
- Advantages of Fluorescent Probes in GPCR Assays
This happens when prolonged exposure to light in the excitation range causes the emission signal to decrease wavelengths, where fluorescence from the cell components is minimal, as well as expanding the working range
- Fluorescent Ligands Targeting Intracellular Allosteric Binding Site of the Chemokine Receptor CCR2
ligands are versatile molecular tools to study G protein-coupled receptors (GPCRs) and can be used for a range
- Immunomodulatory Role of Neuropeptides in the Cornea
Corneal nerves produce various neuropeptides that have a wide range of functions on immune cells.
- β-arrestin1 and 2 exhibit distinct phosphorylation-dependent conformations when coupling to the...
associate with the active parathyroid hormone 1 receptor (PTH1R) in different complex configurations ("hanging
- In vivo detection of GPCR-dependent signaling using fiber photometry and FRET-based biosensors
Hence, it has wide applicability across a spectrum of neuroscience research, ranging from the study of
- Accelerating GPCR Drug Discovery With Conformation-Stabilizing VHHs
GPCRs respond to a wide variety of signals that range in size from photons to proteins (Foord et al.,
- Cholesterol-Dependent Dynamics of the Serotonin 1A Receptor Utilizing Single Particle Tracking....
2022 "G protein-coupled receptors (GPCRs) are signaling hubs in cell membranes that regulate a wide range
- Cholesterol-Dependent Dynamics of the Serotonin1A Receptor Utilizing Single Particle Tracking: ...
Modes "G protein-coupled receptors (GPCRs) are signaling hubs in cell membranes that regulate a wide range
- Targeted Therapies to Reduce Side Effects in Modern Drug Development
Modern drug development approaches include a range of techniques leveraging structural biology, immunology
- Newly launched antibody libraries put hard-to-drug targets within reach
The drugs also target relatively low-hanging fruit: like cytokines or tyrosine kinase receptors.
- Successful prednisolone or calcimimetic treatment of acquired hypocalciuric hypercalcemia caused...
diseases, (d) showed spontaneously fluctuating Ca levels from approximately normal to near fatally high ranges
- Identification of A2BAR as a potential target in colorectal cancer using novel fluorescent GPCR...
fluorescent GPCR ligands "G-protein coupled receptors (GPCRs) have been largely targeted in a wide range
- Structure-Based Discovery of Negative Allosteric Modulators of the Metabotropic Glutamate Receptor 5
fragment- and seven lead-like compounds were confirmed to bind to the allosteric site with affinities ranging
- Structure-Based Discovery of Negative Allosteric Modulators of the Metabotropic Glutamate Receptor 5
fragment- and seven lead-like compounds were confirmed to bind to the allosteric site with affinities ranging
- Intermolecular Interactions in G Protein-Coupled Receptor Allosteric Sites at the Membrane Interface
We show that besides classical hydrogen bonds, weak polar interactions such as O-HC, O-Br, and long-range
- Luciferase-based GloSensor™ cAMP assay: Temperature optimization and application to cell-based kinet
Nevertheless, the GloSensor™ cAMP assay can be applied to analyze signaling by a wide range of GPCRs
- GPCRs are not simple on-off switches: deep dive into GPCR-ligand interactions
GPCRs are present in a range of conformations, and the binding of a ligand, as well as interactions with desensitization), the same drug acting on the same receptor in the same cellular context can produce a range
- Using Live-cell High-Content Screening to Characterize CB2 Ligands: Insights From 16 Synthetic Cannabinoids
50%) : Compounds including AAN488, AAN584, AAN705, AV19, AV31, AV61, AV64 The ~80–93% displacement range The resulting potencies spanned the low-nanomolar to submicromolar range: Most potent ligands : AAN396
- A Model for the Signal Initiation Complex Between Arrestin-3 and the Src Family Kinase Fgr
Arrestins regulate a wide range of signaling events, most notably when bound to active G protein-coupled
- GPCR Happy Hour – Boston, Sept 2025
support clients worldwide in identifying and optimizing new therapeutic opportunities across a wide range
- The development of modulators for lysophosphatidic acid receptors: A comprehensive review
Lysophosphatidic acids (LPAs) are bioactive phospholipids implicated in a wide range of cellular activities
- GPCRS: AN ODYSSEY FROM STRUCTURE, SIGNALING AND REGULATION TO THERAPEUTICS
Coupled with their ability to respond to a highly diverse range of chemical stimuli, they represent the
- Applications of Fluorescent Probes in Confocal Imaging of GPCRs: From Live to Fixed Cells
Jang W, Senarath K, Feinberg G, Lu S, Lambert NA.
- Radioligands vs. Fluorescent Ligands: Binding Assays
Fluorescent ligands can be used at a broader range of concentration without losing accuracy, as well
- Chemical signaling regulates axon regeneration via the GPCR-Gqα pathway in Caenorhabditis elegans
Chemical communication controls a wide range of behaviors via conserved signaling networks.
- Fluorescence Polarization in GPCR Research
Adapted from: Zhang Y, Tang H, Chen W, Zhang J.
- Constitutive, Basal, and β-Alanine-Mediated Activation of the Human Mas-Related G Protein-Coupled ..
Consequently, the dynamic range for IL-6 detection as an assay for β-alanine-mediated activation of MRGPRD
