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Must-read publications:  A structural modeling study revealing non-canonical mechanisms of chemokine-driven

effectors along the Gαq/Phospholipase C (PLC) pathway, which results in an IkB kinases (IKK)-mediated canonical

non-cognate G proteins can enhance the coupling efficiency of cognate G proteins to GPCRs, thereby amplifying canonical

genes unveiled via RNA polymerase II degradation Growth factor-dependent phosphorylation of Gαi shapes canonical

Activation and Signaling Pathophysiological significance and modulation of the transient receptor potential canonical

pharmacology' Yao Lu and colleagues work on 'Molecular insights into orphan GPCRs relevant to schizophrenia' Carole

Industry News Professor Dame Carol Robinson Received 2023 ASMS John.B.Fenn Award Exscientia Announces

Carbon dioxide-induced decrease in extracellular pH enhances the production of extracellular matrix components

of titratable residues spans from the extracellular surface to the transmembrane area, linking with canonical

Small-molecule targeting of GPCR-independent non-canonical G protein signaling inhibits cancer progression

We’ve also highlighted the latest research on non-canonical internalization mechanisms of mGlu receptors

Leukotriene B4 receptor 2 governs macrophage migration during tissue inflammation From odor to oncology: non-canonical

Chemistry GPCR Activation and Signaling SNX9 family mediates βarrestin-independent GPCR endocytosis A non-canonical

spatially selective GPCR signaling GRK5 promoted renal fibrosis via HDAC5/Smad3 signaling pathway Non-canonical

experimental design, wet lab work is performed to acquire high-content cell images, which then require several canonical

Non-canonical Golgi-compartmentalized Gβγ signaling: mechanisms, functions, and therapeutic targets.