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Results found for "GPCR Research"
- Prostaglandin signaling in ciliogenesis and development
Many G-protein-coupled receptors (GPCRs) including EP4 are localized in cilia for modulating cAMP signaling
- Deficiency of β-arrestin2 alleviates apoptosis through GRP78-ATF6-CHOP signaling pathway in ...
is a key protein that mediates desensitization and internalization of G protein-coupled receptors (GPCRs This research further clarified the underlying role of β-arrestin2 and provided an experimental foundation
- Applications of Cryo-EM in small molecule and biologics drug design
cryo-EM has enabled insights into important drug target families such as G protein-coupled receptors (GPCRs
- Engineered synaptic tools reveal localized cAMP signaling in synapse assembly
Given that postsynaptic latrophilin adhesion-GPCRs drive synapse formation and produce cAMP, we suggest
- Disentangling bias between G q, GRK2, and arrestin3 recruitment to the M 3 muscarinic acetylcholine
G protein-coupled receptors (GPCRs) transmit extracellular signals to the inside by activation of intracellular
- On-cell nuclear magnetic resonance spectroscopy to probe cell surface interactions
characterize ligand interactions with cell surface membrane proteins such as G-protein coupled receptors (GPCRs
- Target Residence Time: The Hidden Driver of In Vivo Efficacy
And when receptors are dense (like GPCRs on membranes), this rebinding hits the collisional limit , where
- Free-Energy Simulations Support a Lipophilic Binding Route for Melatonin Receptors
"The effects of the neurohormone melatonin are mediated by the activation of the GPCRs MT1 and MT2 in
- Odorant G protein-coupled receptors as potential therapeutic targets for adult diffuse gliomas ...
and review Odorant receptors (ORs) account for about 60% of all human G protein-coupled receptors (GPCRs
- Synaptic integration of subquantal neurotransmission by co-localized G protein coupled receptors in
Colocalization of different actions of GPCRs provide synaptic integration within presynaptic terminals
- HBx induces hepatocellular carcinogenesis through ARRB1-mediated autophagy to drive the G 1/S cycle
dependent kinase inhibitor 1B; CQ: chloroquine; E2F1: E2F transcription factor 1; FBS: fetal bovine serum; GPCRs
- Exendin-4 Attenuates Remodeling in the Remote Myocardium of Rats After an Acute Myocardial ...
Exendin-4, and possibly through G protein-coupled receptors (GPCRs), increases levels of cAMP and upregulates
- New role of β-arrestins in MOR signaling
Opioid receptors belong to class A of G protein-coupled receptors or GPCRs and signaled mainly through
- Early Stage Biotech Hiring: What Really Holds a Team Together When the Science Starts to Drift
In teams working on complex biology like GPCR targets, this kind of drift is not unusual.
- Reflections on My PhD Journey: Lessons Learned
environment, paired with a supportive supervisor, laid the foundation for a fulfilling and productive research Supervisors not only guide your research but also shape your academic and professional growth. These mini "journal clubs" kept me informed about the latest research and sharpened my critical thinking choose a lab and mentor that align with your values and goals, embrace the discipline of structured research challenges will test your resolve, but every small victory along the way shapes you into a stronger researcher
- From Lab Logic to Leadership: How Scientific Thinking Holds Back Biotech Operations
. 👉 Most founders don’t even realize they’re still running their company like an academic research group scientific thinking can become a leadership liability and what mindset shifts are needed to evolve from research In research, acting on incomplete or shaky data can destroy your credibility. Startups Play by Different Rules — and Most Scientific Founders Miss That A research lab is designed Founders who keep operating like researchers often create internal confusion.
- Understanding Orthosteric Binding: The Key to Drug Action
This foundational knowledge guides researchers in the development of new therapeutics. By considering factors like the Langmuir adsorption isotherm and binding curves, researchers can better
- SLAS2022 International Conference and Exhibition
Don't miss the chance to present your innovative research at this year's conference.
- TeachOpenCADD - A teaching platform for computer-aided drug design
both the theoretical as well as practical aspect of these topics, the platform addresses students and researchers
- How to Avoid the Most Common Gaps in Your Biotech Pitch
But your audience isn’t evaluating you as a researcher.
- Why Biotech Fundraising Fails Due to Intellectual Property Gaps
Patents focused on one indication, while the business story targets another 👉 Claims that protect research
- The Real Cost of Strategic Overload in Biotech
A grant opportunity aligns with ongoing research. A potential partner shows interest.
- Biotech Startup Failure: Why Teams Drift Off Course Without a Single Wrong Decision
They search for flawed assumptions, weak data, or execution gaps. But drift does not live there. Research advances. New initiatives start. Additional questions are explored.








