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- HBx induces hepatocellular carcinogenesis through ARRB1-mediated autophagy to drive the G 1/S cycle
dependent kinase inhibitor 1B; CQ: chloroquine; E2F1: E2F transcription factor 1; FBS: fetal bovine serum; GPCRs
- New role of β-arrestins in MOR signaling
Opioid receptors belong to class A of G protein-coupled receptors or GPCRs and signaled mainly through However, opioids that prevent recruiting β-arrestin 2 do not address the problem since ligands that only
- Exendin-4 Attenuates Remodeling in the Remote Myocardium of Rats After an Acute Myocardial ...
Exendin-4, and possibly through G protein-coupled receptors (GPCRs), increases levels of cAMP and upregulates
- FDA Approval Is a Strategy Obstacle, Not a Paperwork Problem
It’s about building forward with fewer surprises, fewer iterations, and fewer expensive course corrections
- The Five Traps of Ignoring Kinetics
No more blind spots, only decisions rooted in reality. Think of it like catching a train: two passengers have tickets (affinity), but only the one who sprints Unlock “Kinetics: Advanced Applications” Only in Terry’s Corner Why Terry’s Corner Most pharmacology
- What If Your Data is Lying to You? The Calcium Assay Dilemma
Imagine running a calcium assay and discovering your compound shows only weak activity.
- Reflections on My PhD Journey: Lessons Learned
Supervisors not only guide your research but also shape your academic and professional growth. This approach not only ensures that you remain on top of your findings but also makes the thesis-writing
- Conjugation Strategies for Probe Development
NHS esters are not very stable even in aqueous environment but they only need a slightly basic medium Not only do they work in aqueous medium, but also in aprotic solvents like DMF, where you will need to
- Curve Shifts Don’t Lie, But Your Eyes Might
No more guesswork, only decisions you can trust. Unlock “Statistical Analysis” now Only in Terry’s Corner Why Terry’s Corner Your work demands clarity
- From Lab Logic to Leadership: How Scientific Thinking Holds Back Biotech Operations
unpack the three core “rules” most scientific founders unconsciously carry into their companies: 1️⃣ “Only 👉 Bottom line: Scientific thinking is invaluable, but only when it’s reframed for the role you’re
- The Hidden Burn: How Internal Misalignment Drains Your Biotech’s Runway
The team only finds out when timelines shift. It does not go away with more meetings, louder all-hands sessions, or rewritten pitch decks. 👉 It only
- TeachOpenCADD - A teaching platform for computer-aided drug design
While documentation for such tools is available, only few freely accessible examples teach underlying
- Canonical chemokine receptors as scavenging “decoys”
Although less characterized, canonical CKRs have also been shown to not only directly regulate migration
- Scientific Isolation: The Real Reason Early Biotechs Lose Traction
. ✅ If you can’t do that, you’re isolated. 2️⃣ Internal Decision Systems (Do decisions only happen when
