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in high-resolution techniques to investigate peptidergic transmission and expression throughout the brain

This compound has vastly reduced brain penetration and is devoid of significant off-target liability.

Crinetics hires people with big brains and small egos.”

The adenosine A1 and A2A receptors are expressed in the human brain and have a proposed involvement in

The adenosine A1 and A2A receptors are expressed in the human brain and have a proposed involvement in

In other brain regions, astrocytes sense diverse neurotransmitters and neuromodulators and, in turn,

Mouse models have provided invaluable information on the roles for PKA subunits in brain and key metabolic

mechanisms N. meningitidis employ to manipulate the immune system, translocate the mucosal and blood-brain

TGR5 is widely distributed in the brain, lung, heart, liver, spleen, pancreas, kidney, stomach, jejunum

accumbens shell and structures in the prefrontal cortex and amygdala, which were previously linked to the brain

immune system, including neutrophils, monocytes, and macrophages in the periphery and microglia in the brain

treatment of neuropathic pain, a debilitating condition caused by damage to the nerves outside of the brain

New Insights into MRP3 Transporter Function "Glioblastoma is the most common and aggressive primary brain

quantitative Western blot analysis of CB1 receptor expression on crude synaptosomes of the adult rat brain

G-protein coupled receptors (GPCRs) play a paramount role in diverse brain functions.

GnIH) system in the European sea bass, Dicentrarchus labrax, which exerted an inhibitory action on the brain-pituitary-gonadal

We found that Adgra1 is highly and exclusively expressed in the brain, suggesting that Adgra1 may be

However, the pharmacokinetic properties of DOI differed among sexes - brain and plasma concentrations

Recordings in brain slices have shown that co-activation using saturating concentrations of agonists

and mGluR2-mediated increase in pathogenic tau but also show that β-arrestin1 levels are increased in brains

In structured, diffusion-restricted environments (e.g. brain, tumors), drugs don't just leave slowly;

CB1R are mainly found in the central nervous system (CNS) and the brain.

shows data from risperidone, comparing offset rates in open compartments vs. restricted ones like the brain

Mouse Models of Social Interaction and Cognitive Impairment GPCRs in Neuroscience The Drosophila blood-brain

Bryan Roth, Sudarshan Rajagopal, and Graeme Milligan. Save the date! Dr.

Neuroscience Dopaminergic Input Regulates the Sensitivity of Indirect Pathway Striatal Spiny Neurons to Brain-Derived

Bryan Roth, Peter Gmeiner, and Thomas P. Sakmar this week. For Dr.

Bryan Roth's work on "Built-in functional selectivity in neurons is mediated by the neuronal protein,

Understanding Neuropeptide Transmission in the Brain by Optical Uncaging and Release.

protein-coupled receptors: A target for microbial metabolites and a mechanistic link to microbiome-immune-brain