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treatment of neuropathic pain, a debilitating condition caused by damage to the nerves outside of the brain

distinct GPCR phosphorylation patterns, which influence their conformational states and functions (Matthees role in determining the formation of protein complexes and their functions within specific tissues (Matthees

New Insights into MRP3 Transporter Function "Glioblastoma is the most common and aggressive primary brain

quantitative Western blot analysis of CB1 receptor expression on crude synaptosomes of the adult rat brain

GnIH) system in the European sea bass, Dicentrarchus labrax, which exerted an inhibitory action on the brain-pituitary-gonadal

G-protein coupled receptors (GPCRs) play a paramount role in diverse brain functions.

We found that Adgra1 is highly and exclusively expressed in the brain, suggesting that Adgra1 may be

However, the pharmacokinetic properties of DOI differed among sexes - brain and plasma concentrations

Sridharan R, Zuber J, Connelly SM, Mathew E, Dumont ME.

Recordings in brain slices have shown that co-activation using saturating concentrations of agonists

and mGluR2-mediated increase in pathogenic tau but also show that β-arrestin1 levels are increased in brains

you with the kinetic models and biological context needed to design drugs that actually work where it matters In structured, diffusion-restricted environments (e.g. brain, tumors), drugs don't just leave slowly;

I’m running into a problem and I know you work on something similar — can I pick your brain for one minute

CB1R are mainly found in the central nervous system (CNS) and the brain.

shows data from risperidone, comparing offset rates in open compartments vs. restricted ones like the brain Same Affinity, Different Outcomes: Why Residence Time Matters More Two ligands.

company mantra Investor communication feels reactive and apologetic Key documents live in the CEO’s brain It causes a slow erosion of everything that matters. 1️⃣ External Trust Collapses Quietly Investors requires: A crisp BD trajectory that evolves every quarter A 1–2 page positioning document (“Why This Matters

Metabolic Disease and GLP-1 After his PhD, Hodson entered neuroendocrinology — the “interface” between brain Sometimes the experiments you almost quit are the ones that matter most. Why it matters: Personalizing care depends on understanding biological variability. Why it matters: Muscle mass shapes longevity, resilience, and overall metabolic health. Why it matters: Cell-specific delivery reduces off-target effects and boosts efficacy.

Mouse Models of Social Interaction and Cognitive Impairment GPCRs in Neuroscience The Drosophila blood-brain

Bryan Roth, Sudarshan Rajagopal, and Graeme Milligan. Save the date! Dr.

Neuroscience Dopaminergic Input Regulates the Sensitivity of Indirect Pathway Striatal Spiny Neurons to Brain-Derived

Bryan Roth, Peter Gmeiner, and Thomas P. Sakmar this week. For Dr.

Bryan Roth's work on "Built-in functional selectivity in neurons is mediated by the neuronal protein,

Bryan L Roth study on Illuminating the understudied GPCR-ome Save the dates: February 8 - 29: Dr.

Understanding Neuropeptide Transmission in the Brain by Optical Uncaging and Release.

GPR84 is a Gi‐coupled class A GPCR mainly expressed in immune cells and microglia in the brain (Wojciechowicz

essential for developing new treatments for these disorders and advancing our understanding of the brain

History and function of the lactate receptor GPR81/HCAR1 in the brain: a putative therapeutic target

GPCRs in Neuroscience Physiological Condition Dependent Changes in Ciliary GPCR Localization in the Brain

INSL5 chimeric peptide ligand for NanoBiT complementation binding assays Generation of a deep mouse brain

GPCRs in Neuroscience Physiological Condition-Dependent Changes in Ciliary GPCR Localization in the Brain