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G-protein coupled receptors (GPCRs) play a paramount role in diverse brain functions.

GnIH) system in the European sea bass, Dicentrarchus labrax, which exerted an inhibitory action on the brain-pituitary-gonadal

We found that Adgra1 is highly and exclusively expressed in the brain, suggesting that Adgra1 may be

However, the pharmacokinetic properties of DOI differed among sexes - brain and plasma concentrations

Recordings in brain slices have shown that co-activation using saturating concentrations of agonists

and mGluR2-mediated increase in pathogenic tau but also show that β-arrestin1 levels are increased in brains

Sridharan R, Zuber J, Connelly SM, Mathew E, Dumont ME.

you with the kinetic models and biological context needed to design drugs that actually work where it matters In structured, diffusion-restricted environments (e.g. brain, tumors), drugs don't just leave slowly;

CB1R are mainly found in the central nervous system (CNS) and the brain.

shows data from risperidone, comparing offset rates in open compartments vs. restricted ones like the brain Same Affinity, Different Outcomes: Why Residence Time Matters More Two ligands.

Mouse Models of Social Interaction and Cognitive Impairment GPCRs in Neuroscience The Drosophila blood-brain

Bryan Roth, Sudarshan Rajagopal, and Graeme Milligan. Save the date! Dr.

Neuroscience Dopaminergic Input Regulates the Sensitivity of Indirect Pathway Striatal Spiny Neurons to Brain-Derived

Bryan Roth, Peter Gmeiner, and Thomas P. Sakmar this week. For Dr.

Bryan Roth's work on "Built-in functional selectivity in neurons is mediated by the neuronal protein,

Understanding Neuropeptide Transmission in the Brain by Optical Uncaging and Release.

Bryan L Roth study on Illuminating the understudied GPCR-ome Save the dates: February 8 - 29: Dr.

GPR84 is a Gi‐coupled class A GPCR mainly expressed in immune cells and microglia in the brain (Wojciechowicz

essential for developing new treatments for these disorders and advancing our understanding of the brain

History and function of the lactate receptor GPR81/HCAR1 in the brain: a putative therapeutic target

GPCRs in Neuroscience Physiological Condition Dependent Changes in Ciliary GPCR Localization in the Brain

INSL5 chimeric peptide ligand for NanoBiT complementation binding assays Generation of a deep mouse brain

GPCRs in Neuroscience Physiological Condition-Dependent Changes in Ciliary GPCR Localization in the Brain

Methods & Updates in GPCR Research Illuminating the brain-genetically encoded single wavelength fluorescent

Superconserved receptors expressed in the brain: Expression, function, motifs and evolution of an orphan

Therapy Research Structure Therapeutics Receives R&D Achievement of the Year Award for GPCR Research Bryan

perspectives of GPCR-based genetically encoded fluorescent indicators for neuromodulators Illuminating the brain-genetically

members of the RGS family are selective for certain GPCRs, as a proof RGS4 which is expressed in the brain

Opioid Receptor-Mediated Regulation of Neurotransmission in the Brain.

finesse dilemma:  When orthosterics hijack the signal vs. when allosterics fine-tune (and why that matters breakthrough: pHSense , a reagent designed to make receptor trafficking visible in the systems that matter Why It Matters Instead of imaging-heavy workflows, pHSense offers a no-wash, plate-reader–ready, high-throughput Subtype specificity:  selectively track receptor subtypes in complex brain tissue. Why It Matters In the CNS, where receptor localization and real-time signaling shape therapeutic outcomes