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David Gloriam and his team present GproteinDb in 2024 Are you looking to hire?

Physiology or Medicine was awarded jointly to Ragnar Arthur Granit, Haldan Keffer Hartline, and George David Shampo, M. A. & Kyle, R. A. Sir Bernard Katz--winner of Nobel Prize in physiology or medicine. Ekaterini Tiligada, C., Tiligada, E. & Ennis, M.

This week's highlight includes congrats to: Makaía M Papasergi-Scott, Peter Gmeiner, Brian K Kobilka,

Continuing Study Addex Therapeutics in the 23rd BioEquity Europe Conference Simon Bekker-Jensen and Mette M

Magdalena M Scharf, Antonella Di Pizio, Ines Liebscher, Hannes Schihada, and Gunnar Schulte et al. on

Devki D Sukhtankar and Pina M Cardarelli's research: Burixafor Hydrobromide (GPC-100) effects on hematopoietic

Kathleen M Caron and her team studied the GPER/GPR30 complex with β1-adrenergic receptor and AKAP5 in

K ´ onigstorfer, M. Mozhayeva, Y. Sara, T.C. Südhof, and ¨ E.T. Kavalali. 2001.

Non-Peptide Small Molecule GLP-1 Receptor Agonist GSBR-1290 Crinetics Pharmaceuticals Appoints Robert M.

José Labandeira-García , Rafael Franco Endomembrane GPCR signaling: 15 years on, the quest continues Davide

Greetings, avid readers! Nayara Braga Emidio, Ross Cheloha, Laura M Wingler, et al. for their work on Nanobody-Mediated Dualsteric

is quite stable, the number of ORs expressed in different human tissues is highly variable from more than genito-urinary system, the activation of ORs was shown to influence the motility of spermatozoa (Spehr M.

Working closely with Professor David Parker of Durham University, Trinquet’s group cracked the scaffold

Maziarz, M., et al., Revealing the Activity of Trimeric G-proteins in Live Cells with a Versatile Biosensor

a GPCR Paper with his team: Targeted Drug Design through GPCR Mutagenesis: Insights from β2AR China M

insights into G protein coupling specificity at a class A GPCR Jianjun Cao, Arthur Christopoulos, Patrick M.

highlighted a new hydrophobic conserved motif composed of phenylalanine (F)/leucine (L) and methionine (M) each G protein with the receptor showed that there are more polar interactions in Gq/Gs engagements than

Another produces a larger shift in EC₅₀ in one system than another, and we assume we’ve found therapeutic It prevents discovery teams from advancing compounds based on artifacts of expression systems rather than A development decision may hinge on assay sensitivity rather than molecular behavior. practical solution: use a potency metric that incorporates both efficacy and EC₅₀ (log maximal response divided Strategic Implications for Drug Hunters Quantifying receptor selectivity correctly does more than refine

Rather than focusing solely on explaining receptor behavior post hoc, his group began developing workflows Carlsson notes that it’s easier to find pharmacologists to run assays than it is to persuade chemists former students now work in industry, where their ability to bridge the computational-experimental divide

GPCRs are divided into six classes based on amino acid sequence similarities, but only four of the classes

Gq, Gs, Gi, G12 and G13 engagements with GPR110 reveals details of G-protein engagement, including a dividing

These receptors have much larger binding pockets than the majority of GPCRs that have been successfully ’ interaction ensures that all molecules in the library are specific for the target receptor rather than either G protein signaling or arrestin signaling, and superagonists with signaling activity higher than Orion’s CCR2 antagonist analog (OB-004), discovered in only 6 months, is considerably more potent than Library-based screening methodology for engineering small protein GPCR ligands Paolini-Bertrand, M.

robustly both in the peripheral nervous system and in central circuits like the prefrontal cortex and thalamus despite these targets falling short clinically: “The downstream cascade is probably a little bit weaker than hitting a GPCR... and honestly, like with the trials, they were not really that sufficiently better than

This may be broadly divided into studies focused on obtaining detailed molecular information in the intracellular

Drawing on more than 25 years of GPCR expertise, Eurofins DiscoverX delivers one of the industry’s most “They offer more than assays—they build true scientific partnerships that help teams get the most from With more than 25 years of expertise and coverage of over 90% of the human GPCRome, Eurofins DiscoverX

With street-level contamination rising faster than medicine can adapt, Catherine’s work shows why overdose A Crisis That’s Redefining Overdose In 2023, more than 107,000 Americans died from drug overdoses , the The insight is simple but urgent: the drug supply evolves faster than medicine.   The Urgency Ahead Every overdose today is more complicated than the last. And the illicit supply is moving faster than clinical medicine can adjust.

Her story is about more than experiments or data points. Rather than treating opioid pharmacology as a purely theoretical exercise, she collaborates with harm-reduction Academic success is less about prestige than about impact. That urgency, more than titles, positions, or prestige, is what sustains a lasting career in science. Catherine’s story shows that when purpose drives research, science becomes more than a job—it becomes

But that is exactly why they matter more than we think. ever wondered why effort does not always translate into results, the answer often lives much earlier than 👉 Milestones, progress signals, and success criteria are often assumed rather than agreed upon. Tradeoffs feel intentional rather than painful. has room to shape behavior rather than react to it.

Milestones are chosen for narrative strength rather than strategic leverage. recent round, this is an opportunity to recognize where pressure may already be shaping decisions more than Milestones are selected for narrative clarity rather than strategic necessity. What helps the raise starts to matter more than what strengthens the company. 👉 In practice, biotech quality under pressure. 👉 As fundraising intensity increases, they slow down decision-making rather than

Rather than carving out turf, they grew by designing around collective capacity . environment lowers friction between these specialties, making innovation structurally inevitable rather than The structure you train in often matters more than the experiment you start with. Weekly seminars were mandatory but lightweight, designed to connect  rather than perform.