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Be sure to signup for the next Virtual Cafe of Dr. GPCR on the 24th of June! This time, the GPCRdb team ( Dr. David Gloriam , Dr. Reserve your spot for free at: https://www.ecosystem.drgpcr.com/dr-gpcr-virtual-cafe/ #GPCR #GPCRs #DrGPCR

Join us for a fantastic introduction to GPCRdb with Dr. David Gloriam and Dr. Albert Kooistra. Register today: https://www.ecosystem.drgpcr.com/dr-gpcr-virtual-cafe/ #gpcr #drgpcr #virtualcafe

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Join us for the first virtual cafe talk to hear about the amazing work that Dr. Brian Arey is doing. https://www.ecosystem.drgpcr.com/dr-gpcr-virtual-cafe/ #gpcr #drgpcr #virtualcafe

September 2022 "Morphine, the most widely used analgesic, relieves severe pain by activating the μ-opioid receptor (MOR), whereas naloxone, with only slight structural changes compared to morphine, exhibits inhibitory effect, and is used to treat opioid abuse. The mechanism by which the MOR distinguishes between the two is unclear. Molecular dynamics (MD) simulations on a 1-μs time scale and metadynamics-enhanced conformational sampling are used here to determine the different interactions of these two ligands with MOR: morphine adjusted its pose by continuously flipping deeper into the pocket, whereas naloxone failed to penetrate deeper because its allyl group conflicts with several residues of MOR. The endogenous peptide ligand endomorphin-1 (EM-1) underwent almost no significant conformational changes during the MD simulations. To validate these processes, we employed GIRK4S143T, a MOR-activated Gβγ-protein effector, in combination with mutagenesis and electrophysiological recordings. We verified the role of some key residues in the dynamic recognition of naloxone and morphine and identified the key residue I322, which leads to differential recognition of morphine and naloxone while assisting EM-1 in activating MOR. Reducing the side chain size of I322 (MORI322A) transformed naloxone from an inhibitor directly into an agonist of MOR, and I322A also significantly attenuated the potency of MOR on EM-1, confirming that binding deep in the pocket is critical for the agonistic effect of MOR. This finding reveals a dynamic mechanism for the response of MOR to different ligands and provides a basis for the discovery of new ligands for MOR at the atomic level." Read more at the source #DrGPCR #GPCR #IndustryNews

This week at Dr. Dr. Led by Dr. Tom Sakmar and Dr. Modulator for Non-Addictive Pain Relief   A Cell-Permeable Fluorescent Probe Illuminates Early PI(4,5)P₂

This insight from Dr. Tom Sakmar points to a largely overlooked mechanism  in disease: autoantibodies that don’t block receptors A New Role for GPCRs in Disease Sakmar highlights how endothelial cells, which express a wide array of “Some of these antibodies actually activate the receptor and cause pathological signaling.” — Tom Sakmar Sakmar and Kotliar’s system is multiplexed and scalable , able to test hundreds of interactions from

Dr. Tom Sakmar didn’t set out to map GPCR-RAMP interactions across hundreds of receptors. In fact, it all began with a phone call (from Bruce Merrifield, no less) encouraging Sakmar to work on A Long-Term Obsession, Reframed Sakmar’s lab had been focused on the secretin receptor family  for decades “The beauty of multiplexing is that you can do many things with one pot of samples.” — Tom Sakmar Enter Keyword Cloud : GPCR-RAMP interactions , Family B GPCRs , GPCR scientist network , GPCR data platform , Dr

Check out GPCR papers featuring Drs. Bryan Roth, Peter Gmeiner, and Thomas P. Sakmar this week. For Dr. GPCR News, please subscribe to our monthly newsletter. Research Associate Lab Manager Vice President, Medical Affairs Associate Scientist - Technology Explore Dr

This Week’s Highlights: Celebrating Excellence: Hyoungjun Ham , Yamina Berchiche , Thomas Sakmar , Vladimir mutations in a G protein identify signaling cross-talk in T cells Victoria Saca , Colin Burdette , and Thomas Sakmar for their excellent study on GPCR Biosensors to Study Conformational Dynamics and Signaling Gain access to over 500 minutes of recorded classes in our  GPCR courses   taught by Drs. Join us for a stimulating conversation with Dr.

In Episode 167, Dr. Sakmar reflects on a generational shift in training. Building for the Future The Sakmar lab built a system to meet that need: Dual-epitope tagged constructs This delivers all three.” — Tom Sakmar A Use Case for Every Angle Beyond RAMPs, this platform can study

Premium Sneak Peak:  Human Substance P–NK1R interactions observed by NMR; Endocrine Metabolic GPCRs 2026 In this Terry’s Corner lesson, Dr. Hudson 🎧 Catch up on Part 2 with Dr. GPCR Year in Review: Carrying Better Experiments Into 2026 As 2025 closes, the Dr. Beyond access, Premium sustains the nonprofit mission behind Dr.

Dr. GPCR Ecosystem; Dr. P., Macdonald, C. B., Mehrota, E., Grimes, P. R., ... & Manglik, A. (2024).

biosensors reveals distinct conformational signatures of β-arrestin1 and 2 when bound to active PTH1R (P-R Here, we show differences between conformational changes that are induced by P-R* or R* receptor states Read more at the source #DrGPCR #GPCR #IndustryNews Subscribe to the Dr. GPCR Newsletter

This week's highlight includes congrats to: Inês Pinheiro, for her Dr. contributor article Canonical chemokine receptors as scavenging “decoys” Shivani Sachdev, Brendan Creemer, Thomas GPCR University We are excited to announce that Dr. Dr. GPCR Podcast Episode 154 of the Dr. GPCR Podcast on Self-Learning, Collaboration, and Delegation in Science with Dr.

This week's highlight: Drs. Last Friday was our final Dr. GPCR Symposium for the year, focusing on GPCRs in Immunology and Oncology, concluding the Dr. Sign up for Dr. GPCR Newsletter and stay ahead of the curve with news on the Dr. challenge in the Dahl SS rat GPCRs in Neuroscience Neurokinin-2 receptor negatively modulates substance P

It's spring break at Dr. Learn more about Live Masterclasses ➤ Partner Webinars Eurofins DiscoverX (Dr. GeneTex (Dr. Alex Ball)  — A reagent gap that holds back the biology. Details coming soon. Next Week in Boston The Dr. GPCR community gathers in person next week. Come find us ➤ About Dr. GPCR Dr. GPCR is the intelligence and community for GPCR scientists.

Plus, check out the latest Dr. GPCR tools and key moves in the biotech world. Dr. Become a Dr. GPCR Ambassador - Share & refer with Dr. GPCR.   Join the Affiliate Program     Your Shortcut to Dr. The Dr. Best wishes, The Dr. GPCR Team

In Episode 168 of the Dr. GPCR Podcast, Dr. And that mindset is precisely what makes their new partnership with Dr. GPCR so powerful. ” — Dr. That’s the mission. ” — Dr. Maria Majellaro Now, as official partners of the Dr. Keyword Cloud:   GPCR data platform , fluorescent ligands , assay development , GPCR research community , Dr

Dr. Maria Majellaro’s story, shared in Episode 168 of the Dr. ” — Dr. Maria Majellaro Maria didn’t always know she’d end up in a startup. ” — Dr. With the new  Dr. . 👉 Explore Celtarys’ tools and partnership with Dr.

Hello Sweet GPCR Enthusiasts, This week at Dr. GPCR: a new podcast episode with Dr. Ben Clements, a tour of our official Dr. Scroll down for the science, the strategy, and the sweet stuff 🍬 Dr. The official Dr. GPCR Store is live! Best wishes, The Dr. GPCR Team

receptors, data mapper, structure similarity search and models of physiological ligand complexes Luis P Dr. GPCR Kicked Off as a Podcast... go for a Premium Membership , you'll not only back our mission but also snag fantastic perks like: Dr Direct line to the Dr. Jude Children's Research Hospital Welcomes Dr.

, we’re spotlighting Celtarys Research, our newest partner, featured in a blog and podcast with CSO Dr After 40+ years and 250 publications, Dr. Dr. Explore Terry's Corner From Chemistry Lab to GPCR Partner – New Podcast with Celtarys Dr. Stay curious, The Dr. GPCR Team

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As a valued Dr. featuring:   A short, focused video A concise written summary with key takeaways Handpicked references by Dr Your Exclusive Premium Member Benefit:   As a thank you for your continued support of the Dr. GPCR Ecosystem, we're giving Dr. Warmest Regards, The Dr. GPCR Team & Terry’s Desk

This week's highlight includes congrats to: Dr. Jürgen Wess and Liu Liu for their study on A novel function of the M2 muscarinic receptor Drs. GPCR University We are excited to announce that Dr.  Dr. GPCR Podcast The 155th episode of the Dr. Aylin Hanyaloglu, Caroline Gorvin, and Alejandra Tomas.

GPCR Podcast: Leadership, Impact, and GPCR Signaling with Dr. Dr. Yamina’s open letter reflects on how Dr. I wish Dr. No matter where you are in your GPCR journey, Dr.

The Corner comes will live monthly AMA sessions with Dr. Kenakin. GPCR Updates Learn Pharmacology That Drives Discovery  – From Dr. Explore Dr. This blog post breaks down Dr. Stay curious,   The Dr. GPCR Team

Nat Rev Neurosci, 2001. 2 (4): p. 274-86. 3.          Pharmacol Rev, 2016. 68 (4): p. 954-1013. 6.          Nature Communications, 2024. 15 (1): p. 4390. 7.          Mol Pharmacol, 2012. 81 (3): p. 309-18. 9.          Chem Rev, 2017. 117 (1): p. 111-138.

Secure Your Access Now ➤ 🗣️ “Thank you for bringing this (Principles of Pharmacology I) course with Dr I wish Dr. best for the sake of promoting more educational opportunities that are sorely needed in the field” — Dr GPCR University Learner Dr. GPCR Podcast - Surviving Discovery’s Gauntlet Dr. The Dr. GPCR Team Read Full Edition ➤