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antibody showing preclinical efficacy against all COVID-19 variants, including the delta and omicron mutations

cancer treatment through network pharmacology and molecular docking The Effect of Cancer-Associated Mutations protein-coupled receptor complexes for cryo-EM structure determination Molecular Basis of MC1R Activation: Mutation-Induced

Point mutations are in the C-tail of PAR4 PH-binding domain; F347 L and D349A, but not E346A, abrogate

It’s a curated room of GPCR biotech leaders, scientists, and investor professionals  — and space is limited

interacts with arrestin-3 at multiple sites and is consistent with the locations of disease-associated Fgr mutations

Our site-directed mutagenesis results show that mutations of this interface impact the function of the

Using select point mutations, we studied the molecular characteristics that determine the ability of

receptors leads to facilitation of GIRK channel currents, augmenting both amplitude and prolonging the duration

Furthermore, we investigated whether the impact of point mutations, already shown to have deleterious

When does onset rate dictate therapeutic onset, and when does offset rate predict duration?

for:  drug discovery teams, pharmacologists refining their toolkit, and scientists who need trusted, curated

Terry Kenakin Monthly Ask-Me-Anything sessions A growing, curated on-demand library Opportunities to

Furthermore, the activating mutation in egl-30 encoding Gqα suppresses axon regeneration defective phenotype

in GPCR Research Generation of CRISPR/Cas9 modified human iPSC line with correction of heterozygous mutation

Notably, the Y320F mutation restored some signaling capabilities, emphasizing Tyr320's role in membrane

GPCRs in Oncology and Immunology Pan-cancer functional analysis of somatic mutations in G protein-coupled

norepinephrine transporters and their AlphaFold2 predicted water-soluble QTY variants and uncovering the natural mutations

This Week’s Highlights: Harnessing Deep Mutational Scanning for Enhanced Drug Discovery Cam Sinh Lu

In this edition, we have curated eight GPCR papers, five industry news, and two job ads.

Mutations: ML methods can determine stabilising mutations that enable structure determination and can

Unlike orthosterics, they can discriminate between agonists, pathways, and even durations of action.

Heterodimers revolutionize the field of metabotropic glutamate receptors Molecular Basis of MC1R Activation: Mutation-Induced

We have some exciting news, this week we’ve curated 13 GPCR papers, 4 industry news, and 3  job opportunities

This week, we've curated 12 GPCR papers.

Another example is the cannabinoid receptor 1 with a total of 248 SNPs, where 190 missense mutations

Eiken syndrome with parathyroid hormone resistance due to a novel parathyroid hormone receptor type 1 mutation

Pharmaceuticals Announces Positive Phase 3 Results Showing Mavorixafor Reduced the Rate, Severity, and Duration

fibroblast-associated diseases Ultrasensitive dose-response for asbestos cancer risk implied by new inflammation-mutation

Adhesion GPCRs Downstream signaling of the disease associated mutations on GPR56/ADGRG1.

We’ve curated 18 GPCR papers, 8 industry news, and 2 GPCR job offers!