In this foundational lesson, Terry Kenakin dives deep into a widely used, often misunderstood tool in interpretive tools to ask smarter questions, avoid missteps, and use calcium assays with strategic clarity. 📍 Foundational

31 December 2022 Addex Raises $5.0 Million in Equity Financing Testing the limits of SMILES-based de novo

These painstaking manual workflows laid the foundation for what would become the evolution of GPCR research Where once a well-run assay was the pinnacle, now it’s the foundation — a starting point for more ambitious Mini Timeline: Manual assay years — technical rigor as foundation Technology boom — scaling curiosity

Terry Kenakin’s newest foundational lesson in Terry's Corner  cuts straight to it:   Why models are vital

In the newest foundational lesson from Terry Kenakin’s Pharmacology Vault , we unlock the visual language

In the foundational lesson of Terry’s Corner , Dr. Terry Kenakin invites us to challenge outdated assumptions and step into a new era of drug discovery.

In this foundational-level  lesson, Terry unpacks the real-life process behind discovering new drugs,

In this exclusive foundational-level lecture, Dr.

De novo drug design: AI algorithms can generate new molecules with desired properties, such as binding

The Ames test, a foundational bacterial assay, surfaces as an early alert for DNA-modifying liabilities As GPCR science and pharmacological innovation accelerate, timely guidance from foundational to advanced

It was the foundation for his next opportunity: helping launch Cerevel from the ground up. __________

kinetics quietly change about the affinity you think you measured Understanding Orthosteric Binding Foundations Terry Kenakin give scientists an uncommon advantage: the ability to interrogate foundational assumptions ✅ Deep-dive learning paths  — Structured progression from foundational concepts to emerging and expert-level

This innovation emerged from years of foundational work in photophysics and GPCR pharmacology. This was the foundation of a new set of assay tools.

His work highlights how foundational GPCR science can drive therapeutic innovation.

Interpreting Schild Plots — Curves and Slopes Schild analysis remains foundational, but interpretation Use statistics to arbitrate interpretation Design assays deliberately Interpretive discipline is the foundation

Exploring the foundational stages of scientific breakthroughs with Eric Trinquet, highlighting that true It reflects decades of foundational R&D—from the fluorescent probes of Cisbio’s early days to the receptor-targeting

This shift does not mean founders need more patents or heavier legal work. Founders often present patents as proof of strength, while investors read them as indicators of risk Investors then have to fill in the gaps themselves, and that rarely works in the founder's favor. Even experienced founders underestimate how sensitive investors are to ownership details. Importantly, this is rarely about bad decisions by founders.

This collaboration would become the foundation of a GPCR imaging breakthrough that neither of them anticipated excitable tissues and reveal mechanisms driving hormone secretion.That shift in perspective became foundational

The research team, led by Brandon Novy and colleagues, utilized an innovative APEX2/AUR biosensor that

This foundational knowledge guides researchers in the development of new therapeutics.

Founders love the idea that a new year, or a new quarter, will reset the company. the default version Accidental Cadence , the rhythm the company falls into when urgency, science, and founder The Three Components of an Effective Operating Cadence 👉 If you’re a biotech founder, your operating The question is whether you  chose it. 👉 Founders don’t drift because they lack discipline. Attila runs focused strategy consultations for biotech founders  who are ready to lead with clarity,

Mark:  “Have you found this to be accurate?” Beth:  “Yes.  Top candidates will have a solid foundation in GPCR pharmacology as well as some experience in drug discovery

They’re cracks in the foundation. And cracks don’t stay small for long.

modulation of isoform- and ligand specific aGPCR functions using unique tools, and thus establishes a foundation

Founded as a spinout from the University of Dundee on 20 July 2012, Exscientia pioneered the design of patients with advanced haematological cancers, international partnerships with pharma and healthcare foundations

Structured lessons are the foundation.

That discipline—paying attention to the internal spark—became the foundation of his scientific communication

And uncertainty, even when the science is strong, slows biotech fundraising more than most founders expect Why Founders Rationalize Strategic Overload 👉 Strategic overload rarely feels like a mistake. Founders in biotech operate under real pressure. Scientific opportunity is rarely linear. Founders often justify this strain through ambition. The science supports it. Attila runs focused strategy consultations for biotech founders who are ready to lead with clarity, not

Terry Kenakin, with structured lessons as the foundation and live AMAs and workshops where the thinking

While AlphaFold provides an excellent foundation for generating hypotheses in drug discovery, it is not