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At a median follow-up interval of 67.1 months, a significant trend towards reduced distant metastasis-free

expression of each transgenic Gγ in rod cells and restoration of Gαt1 expression, which is greatly reduced

Procrastination may seem tempting, but tackling your work incrementally will save time and reduce stress

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Increased β-arrestin1 in turn drives the accumulation of pathogenic tau, whereas reduced ARRB1 alleviates

phagocytosis, and clathrin-mediated endocytosis (CME) as well as siRNA KD of S2R/TMEM97 significantly reduced

As expected, the ligand affinities of hTAS1R2-VFT were drastically reduced through the introduction of

It’s reversible under non-reducing conditions. [ 4]     Other strategies include click chemistry,  more

When technology reduced the cost of failure, scientists could push boundaries faster.

Constitutive activity of the dopamine receptor D5R, highly expressed in CA1 hippocampal neurons, selectively reduces

A strong agonist, fails to reduce binding of a labeled NAM—not because of irreversibility, but because

heterozygous familial hypocalciuric hypercalcemia type-1 (FHH-1), supported maximal signaling with reduced

these studies identify a new WHIM syndrome mutant, CXCR4-S339fs5, that promotes enhanced signaling, reduced

Results: The complementary DNA (cDNA) sequence and deduced amino acids of HLGR2 were obtained and analyzed

studies of the receptor focused on the potential therapeutic ability for growth hormone (GH) release to reduce

suggest that the melatonin MT2 receptor is expressed in ASM, and modulates airway smooth muscle tone via reduced

Why it matters: Cell-specific delivery reduces off-target effects and boosts efficacy.

GPCR the best for the sake of promoting more educational opportunities that are sorely needed in the

If your team is designing covalent or tight-binding candidates, these principles reduce surprises and

Interestingly, FLNA absence reduced the basal number of hetero-dimers (-36.8 ± 6.3% reduction of PLA

This can be deduced from the qRT-PCR assays; triggering CB1 receptors amplifies both NR4A1 and NR4A3

resistance, to no-wash internalization detection tools, to HTRF ligand optimization techniques that reduce

This means no washing steps are needed to reduce background signal. Figure 1.

GPCRs in Oncology and Immunology Molecular characterization of breast cancer cell pools with normal or reduced

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For drug discovery executives, the message is clear: predictive modeling can shorten timelines, reduce

Terry Kenakin's educational initiative this fall!

By making receptor behavior computationally predictable, Ajay and his team are working to reduce the

demonstrate in male and female rats that GABAB receptors receptors alter Pr, whereas 5-HT1B receptors reduce