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To exert their functions requiring high sensibility and specificity, T cells need to integrate different

We discuss ligand binding, signaling, and structures of the vGPCRs in light of robust differences from

Depending on which ligand activates a receptor, it can engage different intracellular transducers.

and clinical trials to treat idiopathic pulmonary fibrosis are currently ongoing using ligands with differing

These 5HT2C isoforms display differences in constitutive activity, agonist/inverse agonist potencies,

The distinct molecular actions are ascribed to the differences in ligand recognition and dissociation

October 2022 "The role of different G protein-coupled receptors (GPCRs) in the cardiovascular system

protein-coupled receptors (GPCRs) are crucial receptors that regulate a wide range of physiological functions in different

Here, we address this shortcoming by exploring different fusion protein designs, which lead to structures

The choice of pathway can result in different cellular responses, underscoring the criticality of precise several high-throughput screening (HTS) assays for ERK activation have been developed, each utilising different

receptors "Serotonin (or 5-hydroxytryptamine, 5-HT) is an important neurotransmitter that activates 12 different

Previous findings suggest that parallel pathways independently relay innate threat signals from different

The distinct molecular actions are ascribed to the differences in ligand recognition and dissociation

Distinct Ligand Activation in NMBR Simulations show how two ligands differently activate class A GPCR

Recent advances in the structure determination of GPCRs bound to different types of allosteric modulators

The observed differences in the binding affinity and cooperativity arise from the functional groups that

versatile molecular tools to study G protein-coupled receptors (GPCRs) and can be used for a range of different

site-directed) approaches, mutagenesis can provide a comprehensive understanding of how drugs interact with different Furthermore, probing species- or subtype-selectivity introduces complexities due to the differing contexts

Likewise, the relative importance of receptor activation state and ligand function differences have also The distributions of ligand RMSD values were not statistically different for these two conditions, according

By comparing two C5aR receptors C5aR1 and C5aR2 we explained differences between their signaling pathways

This suggests differences in the regulatory function of PI(4,5)P2 between class A and class B GPCRs."

Multiple 14-3-3 isoforms exist, and a GPCR can differentially interact with different 14-3-3 isoforms

and described interactions within its key regions and the bounded ligands to identify their notable differences

TRPM3 expression patterns differ between species and change during development.

September 2022 "The bioactive lysophospholipid sphingosine-1-phosphate (S1P) acts via five different

Several recent studies have demonstrated that TGR5 exerts inconsistent effects in different cancer cells

It has been applied to different GPCR binding assays, such as CXCR4, opioid receptors, CCK1 and CCK2. Discussion The saturation experiments revealed a lower 2-fold difference in the Kd for each CBR receptor A graphic highlighting these differences can be found in Figure 7 . Figure 7. It highlights the difference in affinity of compounds such as SCRAs and other synthetic cannabinoids. Indeed, the difference is lower than 1pKi value between both experiments.

We have explored hydrophobic groups of different sizes on both sides of the five-membered ring scaffold

Colocalization of different actions of GPCRs provide synaptic integration within presynaptic terminals Their effects are profoundly different.

dairy fat biomarker, stimulates insulin secretion and activates G protein-coupled receptors with a different GPCRs in Neuroscience Fine-tuning GPCR-mediated neuromodulation by biasing signaling through different