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Here’s what I bring: Biology-First Strategy I’ve designed GPCR assays, led collaborations across research environments, and translated complex data into action. Firms  – Looking to accelerate, troubleshoot, or validate GPCR assets in their portfolio. ✅ Contract Research

In research, including the GPCR world collaboration isn’t a luxury. It’s survival. The GPCR Collaboration Mindset Behind Breakthrough Science Most researchers have a story about the moment And some simply misled entire research programs. The result was a set of chemical probes that finally allowed researchers to visualize where receptors The Future of GPCR Collaboration in Metabolic Research The next decade of metabolic research won’t hinge

importance of functional selectivity/biased signaling has led to the discovery of biased compounds as both research We discuss the importance of understanding the translatability of cell and animal models to have more

Membership Gives You: Proven frameworks used in real discovery programs On-demand lessons built for tight research GPCR scientists, translational pharmacologists, biotech discovery teams, and decision-makers who need Become a Premium Member today. ➤ 🎓 Full GPCR University + 🔬 200+ expert talks 🗞️ Weekly research, networking, AMAs & matchmaking 💡 Support open resources for the global GPCR field 🧠 Designed for researchers

target-based  discovery is powerful, but can miss the forest for the trees The critical importance of translation

. 👉 Most founders don’t even realize they’re still running their company like an academic research group scientific thinking can become a leadership liability and what mindset shifts are needed to evolve from research In research, acting on incomplete or shaky data can destroy your credibility. Startups Play by Different Rules — and Most Scientific Founders Miss That   A research lab is designed Founders who keep operating like researchers often create internal confusion.

At one point, he even questioned whether research was the right career for him. Still, early research internships were rocky. Discovering Modeling (and GPCRs) by Accident That interest led him to pursue a thesis at Scripps Research For Carlsson, this marked a shift in how his lab approached GPCR research. He came to see that effective GPCR research requires true interdisciplinary integration.

From Bench to Breakthrough: Why pHSense Matters Decades of GPCR research have relied heavily on engineered probes become brighter and have a longer lifespan as internalized receptors enter acidic endosomes—translating behind-the-scenes access to GPCR innovators, exclusive deep-dives, and practical tools to accelerate your research

Over the years, we’ve built a global network of researchers, biotech leaders, and pharma innovators who These sessions bridge structural biology , computational modeling , and clinical translation  — with Scientist GPCR pathways intersect with oncology, CNS, metabolic, cardiovascular, immunology, and fibrosis research

Matthew Eddy and lab research on GPCR signaling mechanisms using NMR spectroscopy with labeled receptors metabolites and a mechanistic link to microbiome-immune-brain interactions Methods & Updates in GPCR Research Scientist NEW In Vitro Biologist/Molecular Pharmacologist Senior Vice President, Oncology Clinical Research Scientist (level I or II) Research Fellow Research Technician II - Surgery Post-Doc Research Associate Research Technician Explore Dr.

Sandra Berndt, Ines Liebscher, and Susanne Horn et. al for their for their research on adhesion GPCR Cryo-electron microscopy for GPCR research and drug discovery in endocrinology and metabolism Reviews World Congress of Basic and Clinical Pharmacology 2026 GPCR Jobs Senior Scientist- Internal Medicine Research Unit Postdoctoral Scholar – Synaptic physiology, optical imaging, substance use disorder, pharmacology Research - Single-molecule Imaging Center Scientific Assistant Postdoctoral Fellowship- Mechanistic Biology Research

How does this translate into a clear safety margin? These aren’t just documentation issues. 6️⃣ Long-term viability signals: Does your data hint at durability, repeatability, or translatability manufacturing processes with scale-up and CMC documentation  in mind You assess safety signals based on their translatability

dissects how spatial GPCR signaling shifts discovery—and how leadership, mentorship, and vision shape translational GPCR scientists, translational pharmacologists, biotech drug discovery teams, and decision-makers who

Keep up-to-date with the latest research and advancements in the field with our convenient, weekly news Methods & Updates in GPCR Research Small Molecule Tools to Study Cellular Target Engagement for the Intracellular Twist Bioscience and Astellas Enter into Multitarget Antibody Discovery Research Collaboration Neurocrine Molecular Pharmacology, Discovery Biology Staff Scientist/Senior Staff Scientist, Disease Biology and Translational

These GPCR pharmacology insights become critical when translating in vitro behavior to tissue environments Translation requires understanding where the ligand sits on the operational curve—not just where it sits Kenakin revealed  the decision workflow for ranking agonists with translational intent.

with its receptor, the consequences ripple across assay development, SAR interpretation, and clinical translation Why now:  GPCR research is accelerating—and the projects that succeed will be those built on clear, accurate

advanced AI models like AlphaFold3, which can predict complex protein-molecule interactions and post-translational The lack of transparency surrounding its operations and usage constraints restricts extensive academic Additionally, transparency in AI models and their operations is crucial for building trust and allowing screening and large-scale data analysis, paving the way for a new era in precision medicine and medical research

grounded understanding of tissue heterogeneity, signal variability, and the biology that makes GPCR research capture receptor dynamics in intact tissue and live animals, expanding what’s possible in both basic research and translational settings. conversation is part of a three episode series produced in collaboration with our partners at Celtarys Research

By systematically mutating every amino acid in the protein and assessing the resulting phenotype, researchers By examining how mutations in the target protein affect its interaction with the drug, researchers can Certain systems might not replicate the natural environment or post-translational modifications observed resources, including time, financial investment, and specialised expertise, limiting accessibility for some research

Recent research has unveiled the emergence of G-protein-independent pathways, particularly those involving Once activated, ERKs translocate to the nucleus, phosphorylating various transcription factors, including The nuclear pathway typically involves ERK translocating into the nucleus to regulate gene expression By understanding the intricacies of GPCR signaling and utilising advanced assay technologies, researchers Current Chemical Genomics and Translational Medicine, 7, 9. Kenakin, T. (2019).

Keep up-to-date with the latest research and advancements in the field with our convenient, weekly news GPCR Activation and Signaling New simulation insights on the structural transition mechanism of Bovine first-line treatment The Lundbeck Foundation is awarding DKK 174 million in grants to seven ‘mind-bending’ research Molecular Pharmacology, Discovery Biology Staff Scientist/Senior Staff Scientist, Disease Biology and Translational

April 2022 "By Sophie Bradley | Apr 12, 2022 Summary Sophie Bradley, Translational Sciences Associate

April 2022 "By Cliona MacSweeney | Apr 20, 2022 Cliona MacSweeney, a project director in our Translational

Schild analysis translates that language. It encourages skepticism—forcing researchers to prove competition before quantifying it.

You don’t need more data—you need a way to translate snapshots into predictions. They take descriptive data from one system and translate it into parameters that can be applied to others

Our study provides mechanistic insights into the regulation of aGPCRs via post-translational modifications

While more work is needed to further elucidate the translational value of selectively targeting CB2 receptors

"New team focused on expanding its GPCR-focused structure-based drug design platform and enhancing translational

In addition, the molecular mechanisms underlying GPCR-induced post-translational signaling regulation

Erythrocytes are terminally differentiated anuclear cells with no transcription and limited translation