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opportunities:  Senior/Principal Scientist—GPCR Pharmacology; Principal Scientist—In Vitro Pharmacology; Research Johannes Broichhagen Reliable imaging tools change how researchers see receptor behavior. This feature from Celtarys Research outlines how to structure an HCS workflow that avoids batch effects It’s a system-aware resource built for researchers who need clarity fast—reinforcing system-level GPCR Weekly research, careers, and industry intelligence; GPCR University; 200+ expert talks; networking;

November 2022 "Neuropeptides produce robust effects on behavior across species, and recent research has Neuropeptides exhibit distinct characteristics which includes their post-translational processing, release Current research has focused on isolating when and how neuropeptide transmission occurs, as well as the

Meanwhile, researchers in the building across the way turned off the lights at 6 PM. Hodson made what seemed like a purely tactical decision: choose a research elective to focus on exams That choice led him to immunology research on pigs — and, eventually, to a PhD. For real translational understanding, you need to see  the receptor in context. That partnership eventually produced fluorescent GPCR tools  that allow researchers to visualize GPCR

The Hidden Lever in GPCR Research In GPCR pharmacology, the conversation often centers on ligand properties—affinity By reducing receptor density, researchers can transform full agonists into partial ones—allowing comparative An assay that reveals drug properties earlier in the pipeline translates directly into better prioritization Assay volume control becomes a tool for risk management, translational prediction, and mechanistic insight

Kenakin’s newest foundational lesson in Terry's Corner  cuts straight to it:   Why models are vital for translating

We have gathered 24 new research papers on GPCRs and updates on industry news related to GPCRs. Kawthar Belkacemi, Philippe Rondard, Jean-Philippe Pin, and Laurent Prézeau, for their research on Heterodimers receptor Astrocytic GPCR signaling in the anterior cingulate cortex modulates decision making in rats Translation-independent ACKR3 Revealed by Single-Molecule Analysis of their Conformational Landscapes Methods & Updates in GPCR Research HIGHLIGHT Principal Scientist, In vitro pharmacology Post-Doctoral Scientist- Molecular Pharmacology (FDE) Research

This week, we focus on integration — how to align scientific disciplines before costly translational These sessions span foundational pharmacology, receptor biology, modeling, translational strategy, and entered a strategic partnership with Eurofins DiscoverX , a global provider of GPCR assay platforms and translational

August 2022 "A confluence of factors has renewed interest in the scientific understanding and translational desire for additional approaches to mental health care, incremental progress in basic and clinical research

relied on: Antibodies of inconsistent specificity Fixed tissue sections Indirect signaling readouts Researchers It’s about how translation happens. Experiments fail for reasons that contain information. conversation is part of a three episode series produced in collaboration with our partners at Celtarys Research

Here’s what I bring: Biology-First Strategy I’ve designed GPCR assays, led collaborations across research environments, and translated complex data into action. Firms  – Looking to accelerate, troubleshoot, or validate GPCR assets in their portfolio. ✅ Contract Research

In research, including the GPCR world collaboration isn’t a luxury. It’s survival. The GPCR Collaboration Mindset Behind Breakthrough Science Most researchers have a story about the moment And some simply misled entire research programs. The result was a set of chemical probes that finally allowed researchers to visualize where receptors The Future of GPCR Collaboration in Metabolic Research The next decade of metabolic research won’t hinge

Also this week: Terry Hébert previews his April 16 session on iPSC-derived translational models, and GPCR University iPSC-Derived Systems for GPCR Signaling and Translation HEK293 systems are powerful tools unconventional ligand classes address long-standing challenges in selectivity, efficacy, and clinical translation

As a receptor's physiological role is clarified through this process, it transitions from an unknown From In Vitro to In Vivo: Closing the Translational Gap in GPCR Pharmacology Even a well-characterized ligand in a cell-based assay faces the challenge of translation to complex biological systems.   pharmacology  occurs in the context of receptor crosstalk, tissue-specific expression patterns, post-translational remain are not whether biased agonism  matters, but how reliably it can be engineered, predicted, and translated

The guidelines will aid consistency and clarity, as the basic receptor research and drug discovery communities and should benefit from and contribute to the implementation of the guidelines, together improving translation

and biosensor-based assays introduce models that better preserve tissue and disease context, and the translational access this session along with 21+ additional masterclasses. iPSC-Derived Systems for GPCR Signaling and Translation iPSC and organoid models enable alignment between signaling profiles and disease-relevant phenotypes Translational

Membership Gives You: Proven frameworks used in real discovery programs On-demand lessons built for tight research GPCR scientists, translational pharmacologists, biotech discovery teams, and decision-makers who need Become a Premium Member today. ➤ 🎓 Full GPCR University + 🔬 200+ expert talks 🗞️ Weekly research, networking, AMAs & matchmaking 💡 Support open resources for the global GPCR field 🧠 Designed for researchers

importance of functional selectivity/biased signaling has led to the discovery of biased compounds as both research We discuss the importance of understanding the translatability of cell and animal models to have more

. 👉 Most founders don’t even realize they’re still running their company like an academic research group scientific thinking can become a leadership liability and what mindset shifts are needed to evolve from research In research, acting on incomplete or shaky data can destroy your credibility. Startups Play by Different Rules — and Most Scientific Founders Miss That   A research lab is designed Founders who keep operating like researchers often create internal confusion.

target-based  discovery is powerful, but can miss the forest for the trees The critical importance of translation

At one point, he even questioned whether research was the right career for him. Still, early research internships were rocky. Discovering Modeling (and GPCRs) by Accident That interest led him to pursue a thesis at Scripps Research For Carlsson, this marked a shift in how his lab approached GPCR research. He came to see that effective GPCR research requires true interdisciplinary integration.

From Bench to Breakthrough: Why pHSense Matters Decades of GPCR research have relied heavily on engineered probes become brighter and have a longer lifespan as internalized receptors enter acidic endosomes—translating behind-the-scenes access to GPCR innovators, exclusive deep-dives, and practical tools to accelerate your research

They fail because the interpretation of that data did not translate to biology outside the assay system In this session, you’ll gain: How pharmacology translates assay signals into biological predictions Why Pharmacology Principles in Action Drug discovery pharmacology principles revolve around one core idea: translation

Over the years, we’ve built a global network of researchers, biotech leaders, and pharma innovators who These sessions bridge structural biology , computational modeling , and clinical translation  — with Scientist GPCR pathways intersect with oncology, CNS, metabolic, cardiovascular, immunology, and fibrosis research

Sandra Berndt, Ines Liebscher, and Susanne Horn et. al for their for their research on adhesion GPCR Cryo-electron microscopy for GPCR research and drug discovery in endocrinology and metabolism Reviews World Congress of Basic and Clinical Pharmacology 2026 GPCR Jobs Senior Scientist- Internal Medicine Research Unit Postdoctoral Scholar – Synaptic physiology, optical imaging, substance use disorder, pharmacology Research - Single-molecule Imaging Center Scientific Assistant Postdoctoral Fellowship- Mechanistic Biology Research

How does this translate into a clear safety margin? These aren’t just documentation issues. 6️⃣ Long-term viability signals: Does your data hint at durability, repeatability, or translatability manufacturing processes with scale-up and CMC documentation  in mind You assess safety signals based on their translatability

Matthew Eddy and lab research on GPCR signaling mechanisms using NMR spectroscopy with labeled receptors metabolites and a mechanistic link to microbiome-immune-brain interactions Methods & Updates in GPCR Research Scientist NEW In Vitro Biologist/Molecular Pharmacologist Senior Vice President, Oncology Clinical Research Scientist (level I or II) Research Fellow Research Technician II - Surgery Post-Doc Research Associate Research Technician Explore Dr.

dissects how spatial GPCR signaling shifts discovery—and how leadership, mentorship, and vision shape translational GPCR scientists, translational pharmacologists, biotech drug discovery teams, and decision-makers who

Reserve your spot ➤ iPSC-Derived Systems for GPCR Signaling and Translation Heterologous systems such live masterclasses, full replays, and access to the complete Masterclass Library, alongside curated research

These GPCR pharmacology insights become critical when translating in vitro behavior to tissue environments Translation requires understanding where the ligand sits on the operational curve—not just where it sits Kenakin revealed  the decision workflow for ranking agonists with translational intent.

Keep up-to-date with the latest research and advancements in the field with our convenient, weekly news Methods & Updates in GPCR Research Small Molecule Tools to Study Cellular Target Engagement for the Intracellular Twist Bioscience and Astellas Enter into Multitarget Antibody Discovery Research Collaboration Neurocrine Molecular Pharmacology, Discovery Biology Staff Scientist/Senior Staff Scientist, Disease Biology and Translational