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Not possible when nothing’s built to surface the right  insights early. I install simple tools that surface insights, align your team, and keep momentum moving. My Consulting Philosophy Every successful GPCR program is a blend of scientific excellence  and operational need clarity ✅ Yamina’s Corner helps teams move from data chaos to decisive action ✅ This is hands-on support

receptor antagonists at BMS to opioid receptor research at Alkermes and early-stage work at Cerevel and Superluminal

team fit , not just credentials He designed lab workflows that encouraged curiosity without burnout He supported Sokhom knew this instinctively and built a system to support it.

Watch Episode 169 What if you could earn a PhD while supporting a family and working full time in drug

Plus: must-read chemokine and PTH1R papers, and new momentum across biotech—from Superluminal to Neurocrine Terry Kenakin with short videos, clear summaries, and curated references. execution, and scalable systems, it turns scattered data into decisions, accelerating your path to a successful

You'll learn why some agonists succeed in sensitive tissues but fail elsewhere—and how this knowledge

Here’s the surprising truth: up to 80% of GPCR-targeted drugs fail—not because of poor chemistry, but

Whether supporting CROs, academic labs, or pharma teams, Celtarys engages deeply with collaborators to chemical probes and make assay development faster, cheaper, and more customizable. 👉 See how Celtarys can support

Subscribe to The Kenakin Brief below to stay in the know. development contexts Advance with nuanced lessons on allostery, residence time, and translational PK/PD   Subscribe CXCR4 oligomerization  sustains oncogenic signaling in lymphoid neoplasms, and its disruption boosts

Watch Episode 168 Success in science is rarely linear. In fact, her early decisions were based on curiosity, instinct, and a surprising love of cooking (yes

Kotliar sums it up best: “We went from one receptor to many… and now, from many, we can go back to one

Research develops high-quality, fluorescently labeled ligands and innovative chemical biology tools to support “We’re excited to support the GPCR community with tools that deliver clarity, sensitivity, and speed,

Watch Episode 167 What started with a single receptor became a toolset for an entire superfamily.

Knowing the difference is survival.

• Leadership that supports academic career paths • A team that communicates under pressure • Space

Show off your receptor pride and support the mission. The official Dr. GPCR Store is live! A stunning cryo-EM structure of the sweet taste receptor (TAS1R2–TAS1R3) shows how aspartame and sucralose From sugar-sensing structures to strategic partnerships—GPCRs remain at the center of it all.

Every insight you share helps us build a smarter, more supportive GPCR community—together. It’s a simple way to share valuable resources and support the field—one connection at a time.  

spotlighting breakthroughs that challenge dogma and deepen our view of receptor dynamics, from the surprising

of GPCR signalling from subcellular compartments in previous studies [44, 47-49]. Trends in clinical success rates and therapeutic focus. Estimation of clinical trial success rates and related parameters. Rational design of allosteric modulators: Challenges and successes. Shen S, Zhao C, Wu C, Sun S, Li Z, Yan W, et al.

We’d love to hear your thoughts on our website and its features  so that we can continue to support your Drug Discovery March 12 - 14, 2025 | NextGen Biomed 2025 March 25 - 28, 2025 | 10th German Pharm-Tox Summit 2025 April 14 - 17, 2025 | 20th Drug Discovery Chemistry April 24 - 27, 2025 | American Physiology Summit vomeronasal neuroepithelium reveals a differential endoplasmic reticulum environment amongst neuronal subtypes

and transmembrane domains modulates holo-adhesion GPCR function Szymon P Kordon , Kristina Cechova , Sumit We are bursting with pride in sharing it with you, and we sincerely want to thank you for your support Drug Discovery March 12 - 14, 2025 | NextGen Biomed 2025 March 25 - 28, 2025 | 10th German Pharm-Tox Summit 2025 April 14 - 17, 2025 | 20th Drug Discovery Chemistry April 24 - 27, 2025 | American Physiology Summit Corticotropin-releasing factor-like diuretic hormone 44 and five corresponding GPCRs in Drosophila suzukii

Levitz , Ben Jones , Johannes Broichhagen Design of allosteric modulators that change GPCR G protein subtype GPCR University 🎥 Recorded GPCR Courses and Symposia / Summit 💲 Special Pricing on GPCR courses It's like having a treasure map to academic success! Thanks for understanding and supporting us! 2025 April 14 - 17, 2025 | 20th Drug Discovery Chemistry April 24 - 27, 2025 | American Physiology Summit

GPCR University 🎥 Recorded GPCR Courses and Symposia / Summit 💲 Special Pricing on GPCR courses This will support our operations and community growth. Thank you for your understanding and support! Drug Discovery March 12 - 14, 2025 | NextGen Biomed 2025 March 25 - 28, 2025 | 10th German Pharm-Tox Summit 2025 April 14 - 17, 2025 | 20th Drug Discovery Chemistry April 24 - 27, 2025 | American Physiology Summit

What ultimately made the difference was my PhD supervisor’s initiative to reach out. The right environment, paired with a supportive supervisor, laid the foundation for a fulfilling and The Role of Mentors and Supervisors Having the right mentor is indispensable for a successful PhD journey Supervisors not only guide your research but also shape your academic and professional growth. My supervisors played an instrumental role in my growth.

Embrace the excitement of supporting us and unlocking incredible perks such as: Dr. 27, 2024 | 1st Virtual GPCR Forum Conference November 26 - 28, 2024 | GPCRs-Targeted Drug Discovery Summit 2025 April 14 - 17, 2025 | 20th Drug Discovery Chemistry April 24 - 27, 2025 | American Physiology Summit AML cells through the calcium/calcineurin pro-survival pathway and confers chemoresistance by mediating inhibitor, suppresses the TGF-α-induced migration of hepatocellular carcinoma cells via inhibition of

This strategic decision to limit free content is essential as we need to increase revenue to support Events, Meetings, and Webinars NEW November 18 - 20, 2024 | 7th CB1 & CB2 Targeting Drug Development Summit 27, 2024 | 1st Virtual GPCR Forum Conference November 26 - 28, 2024 | GPCRs-Targeted Drug Discovery Summit Drug Discovery March 12 - 14, 2025 | NextGen Biomed 2025 March 25 - 28, 2025 | 10th German Pharm-Tox Summit 2025 April 14 - 17, 2025 | 20th Drug Discovery Chemistry April 24 - 27, 2025 | American Physiology Summit

The result suggested that, in contrast to other proton-sensitive channels and receptors, GPR68 did not Instead, a collection of titratable residues spans from the extracellular surface to the transmembrane Specifically, the study revealed that the protonation of key residues surrounding an extracellular facing By evaluating a broad spectrum of mutations, DMS can help predict which patient subpopulations will respond to a drug and which might suffer adverse effects.

Get your space suits on, GPCR cadets! 🚀✨ This Week’s Highlights: Congrats to: Ya-Tzu Li , our notable contributor, for her superb undergrad Gi-protein: Insights into internal water channel dynamics within dopamine receptor D3 from in silico submolecular 27, 2024 | 1st Virtual GPCR Forum Conference November 26 - 28, 2024 | GPCRs-Targeted Drug Discovery Summit April 14 - 17, 2025 | 20th Drug Discovery Chemistry NEW   April 24 - 27, 2025 | American Physiology Summit

The 11th Adhesion GPCR Workshop 2024 was a successful event that brought together experts, researchers 27, 2024 | 1st Virtual GPCR Forum Conference November 26 - 28, 2024 | GPCRs-Targeted Drug Discovery Summit Precursor Cells Derived from Patients Diagnosed with Schizophrenia Sphingosine 1-phosphate receptor subtype

Class B1 GPCRs are an important subclass of GPCRs that include 15 receptors involved in regulating body Recent studies suggest that class B1 GPCRs can form both homodimers and heterodimers, which may play Such findings suggest that dimerization is critical for regulating GPCR function, particularly with respect In summary, dimerization in class B1 GPCRs is an emerging area of research that has far-reaching implications While class B1 GPCRs were initially thought to function primarily as monomers, mounting evidence suggests