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Biomed Pharmacother. 2018 Feb;98:222-232. doi: 10.1016/j.biopha.2017.12.056 Azam S, Haque ME, Jakaria

This Week’s GPCR Intelligence: From Set-Point Pharmacology to No-Wash Internalization Assays This week structure-encoded location-biased signaling, GPCR signaling in metabolism, and future directions in biased ligand pharmacology GPCR scientists, translational pharmacologists, biotech discovery teams, and decision-makers who need

Career opportunities:  Snapshot of roles spanning PhD entry points to senior translational pharmacology—Protein Expression, Drug Discovery Scientist, and Staff Scientist in Molecular Pharmacology—curated with notes GPCR scientists, translational pharmacologists, biotech discovery teams, and decision-makers who need

Nordisk looks to next generation of obesity, diabetes drugs with $550M Replicate research deal; Rhythm Pharmaceuticals Associate; Senior Scientist, Data Science—curated roles aligned to GPCR discovery and translational pharmacology GPCR scientists, translational pharmacologists, biotech discovery teams, platform company leaders, and Access this week’s full Premium Edition here ➤ What our members say 🗣️ "The best pharmacology teacher Also super-valuable for those of us learning how to teach pharmacology." — DrGPCR University Attendee

. -            Biased signaling detection Biased pharmacophores may be used in conjunction with fluorescent Flow Cytometry validation performed in the Oncological Pharmacology Laboratory of the University of Turin

By the end, you’ll know how to use pharmacological models to separate lookalikes, explain puzzling outcomes When Two Mechanisms Look the Same Some of the most difficult calls in pharmacology happen when two different Built for discovery-phase teams, pharmacologists refining fundamentals, scientists challenging legacy

His work spans deep academic research, startup life, and the application of machine learning and pharmacology Superluminal Medicines: AI/ML Meets GPCR Pharmacology As Ajay continued to explore how GPCR signaling Despite decades of progress in structural biology and pharmacology, predicting how  a GPCR will respond

for proteins: Tracking the motions of cell receptors; A Better Way to Treat Obesity; Unlocking the pharmacological climbing the spotlight; new tools tracking receptor motion; obesity drug strategies shifting; antibody pharmacology Ajay Yekkirala shares the journey from academic pharmacologist to biotech entrepreneur—bridging curiosity GPCR scientists, translational pharmacologists, biotech discovery teams, and decision-makers who need

This is why fluorescent tags, both attached to the protein or to pharmacophores, are so interesting. In the case of fluorescent ligands , where a fluorescent tag is attached to a pharmacophore , the receptor studies, it facilitates the structural context necessary to map receptor localization in defined states (pharmacological Br J Pharmacol. 2023 Dec 12. doi: 10.1111/bph.16297. 

Terry's Corner - The Truth About Allosteric Displacement Allosteric binding isn’t just a twist in the pharmacology GPCR scientists, translational pharmacologists, biotech discovery teams, and decision-makers who need

Understand the synergistic mechanisms driving the escalating opioid crisis and the crucial role of GPCR pharmacology Problem Solved:  Gain a deeper understanding of the pharmacological underpinnings of opioid overdose, Listen now to understand how two mechanisms intersect—and why pharmacologists are critical in addressing GPCR scientists, translational pharmacologists, biotech discovery teams, and decision-makers who need Access this week’s full Premium Edition here ➤ What our members say 🗣️ “The best pharmacology teacher

They provide rapid and scalable assessment of pharmacological parameters.

Fluorescent Probes in GPCR assays over other methods Fluorescent ligands are made by choosing an adequate pharmacophore They can also further pharmacological and structural studies, as they can be used to determine receptor Our portfolio also includes all kinds of dyes, such as pharmacophores conjugated to near-infrared fluorophores Biomed Pharmacother. 2022 Sep;153:113408. doi: 10.1016/j.biopha.2022.113408. Br J Pharmacol. 2020 Mar;177(5):978-991. doi: 10.1111/bph.14953.

This new learning hub is your go-to space to revisit core pharmacology concepts, master new ones, and Explore Terry's Corner Better decisions start with better pharmacology.

binding pockets —sites that only exist briefly in certain receptor states—can drastically alter the pharmacokinetics Terry’s Pharmacology Corner  delivers trusted, razor-sharp insight to help drug discovery professionals Unlock “GPCRs as Allosteric Machines” Now Only in Terry’s Corner Why Terry’s Corner Terry’s Pharmacology growing, curated on-demand library Opportunities to shape future topics Built for discovery-phase teams, pharmacologists

understanding why intracellular drug access changes everything: from target residence time to diffusion-driven pharmacodynamics accessible from inside the cell ✅ Tools for evaluating scaffold permeability using modern, cost-effective pharmacokinetic In this protected environment, pharmacokinetics can decouple from plasma clearance. This opens up a new pharmacological space—and a reason to revisit “failed” targets with fresh eyes. Persistent binding isn’t just about longer half-lives—it’s about smarter pharmacology.

Born near Venice and trained as a pharmaceutical chemist, Alessandro never imagined himself working at The Early Days: Molecules and Mentors Alessandro began his academic life studying pharmaceutical chemistry

In this eye-opening module, Terry Kenakin explores a concept that could change how you interpret pharmacological

the core mediator  — demonstrating the reach of these signaling pathways beyond classical receptor pharmacology

The Importance of Binding in Drug Action In pharmacology, binding must happen before any drug effect potency, but this isn't always the case due to various biological factors. 📚 Whether you're new to pharmacology You'll gain valuable insights into the critical role binding plays in pharmacology. Understanding the intricate details of drug-receptor interactions transforms how we approach pharmacology

For over two decades, my work has centered on GPCR pharmacology . My Approach: Biology, Execution, Systems My consulting approach uniquely blends deep pharmacology expertise

He was tasked with building an in vitro pharmacology group from scratch , including infrastructure, hiring

Terry walks you through real-world experiments, decades of receptor pharmacology wisdom, and the cutting-edge 🔓 Find the lesson in Terry’s Pharmacology Vault: “Efficacy and System Sensitivity Unlock "Agonism &

What if the way we've been studying GPCRs—arguably the most important drug targets in pharmacology—has

It will bridge foundational receptor theory with today’s most pressing pharmacological questions, from gives you timeless and timely tools to improve selectivity, model efficacy, and design smarter GPCR pharmacology

Terry Kenakin , a veteran pharmacologist with over 40 years of industry experience. If you're just beginning your pharmacology journey… This is the lesson that will connect the dots. You’ll leave with the language, logic, and big-picture view that underpins all future learning in pharmacology

She studied pharmacy with a specialization in pharmaceutical chemistry, a degree that allowed her to

platform enables rapid generation of conjugates, such as labeled ligands, with excellent affinity and pharmacological

that these small, single-transmembrane proteins weren’t just chaperones; they actively shaped receptor pharmacology

“Explaining pharmacology to a new student makes you relearn the basics. It sharpens everything.”