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17th, 2024 Industry News Centessa Launches Phase 2 Trial of ORX750 for Narcolepsy and IH Crinetics Pharmaceuticals to GPCR Drug Discovery March 12 - 14, 2025 | NextGen Biomed 2025 March 25 - 28, 2025 | 10th German Pharm-Tox | BIO International Convention 2025 July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology Principal Scientist, Medicinal Chemistry PhD fellowship in GPCR mechanosensing Senior Scientist, GPCR Pharmacology Research Associate - Professor Graeme Milligan Postdoc in Molecular Pharmacology - The Hauser Group

GPCR University course, 'Applying Pharmacology to Drug Discovery,' led by Dr. and more Nanobody-Mediated Dualsteric Engagement of the Angiotensin Receptor Broadens Biased Ligand Pharmacology Pharmacological characterization and radiolabeling of VUF15485, a high-affinity small-molecule agonist and Drug Discovery March 13 - 15 | 9th German Pharm-Tox Summit March 23 - 24, 2024 | Ligand Recognition 2026 GPCR Jobs NEW Research Fellow NEW  Postdoctoral Fellow – Molecular Pharmacology of Feeding Behavior

GPCR University We're thrilled to share that all spots for the Applying Pharmacology to Drug Discovery Exhibition February 11 - 14, 2024 | 2024 BPS Annual Meeting NEW February 20, 2024 | Career Opportunities in Pharmacology and Drug Discovery March 13 - 15 | 9th German Pharm-Tox Summit March 23 - 24, 2024 | Ligand Recognition , 2024 | 11th Adhesion GPCR Workshop July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology

GPCR University course, Applying Pharmacology to Drug Discovery, led by Dr. The course covers basic pharmacology in four weekly segments and is open to all with a free site membership Conference and Exhibition February 11 - 14, 2024 | 2024 BPS Annual Meeting NEW March 13 - 15 | 9th German Pharm-Tox , 2024 | 11th Adhesion GPCR Workshop July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology

with Domain Therapeutics and Université de Montréal for GPCR-Targeted Drug Discovery "Apr.19.2022 Ono Pharmaceutical

GPCR University This week marks the beginning of our first Dr.GPCR University course, 'Applying Pharmacology Webinars February 11 - 14, 2024 | 2024 BPS Annual Meeting February 20, 2024 | Career Opportunities in Pharmacology and Drug Discovery March 13 - 15 | 9th German Pharm-Tox Summit March 23 - 24, 2024 | Ligand Recognition , 2024 | 11th Adhesion GPCR Workshop July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology

July 2022 "Not even a PIPE financing could save X4 Pharmaceuticals from enacting layoffs and trimming

June 2022 "CRN04894 Selected for Oral Presentation SAN DIEGO, June 8, 2022 — Crinetics Pharmaceuticals

Trevena Announces Submission of New Drug Application in China for OLINVYK® by its Partner Jiangsu Nhwa Pharmaceutical The NDA was submitted by Trevena’s partner, Jiangsu Nhwa Pharmaceutical, and follows completion by Nhwa

Pharmacological chaperones are cell-permeant small molecules that engage nascent mutant GPCRs in the Therefore, CAN1404 acts as a pharmacological chaperone and can rescue cell surface expression and function effects of genetic mutations on GPCR function and provide a proof of therapeutic principle for FSHR pharmacological

GPCRs Are Optimal Regulators of Complex Biological Systems and Orchestrate the Interface between Health and Disease GPCRs arguably represent the most effective current therapeutic targets for a plethora of diseases. GPCRs also possess a pivotal role in the regulation of the physiological balance between healthy and pathological conditions; thus, their importance in systems biology cannot be underestimated. The molecular diversity of GPCR signaling systems is likely to be closely associated with disease-associated changes in organismal tissue complexity and compartmentalization, thus enabling a nuanced GPCR-based capacity to interdict multiple disease pathomechanisms at a systemic level. GPCRs have been long considered as controllers of communication between tissues and cells. This communication involves the ligand-mediated control of cell surface receptors that then direct their stimuli to impact cell physiology. Given the tremendous success of GPCRs as therapeutic targets, considerable focus has been placed on the ability of these therapeutics to modulate diseases by acting at cell surface receptors. In the past decade, however, attention has focused upon how stable multiprotein GPCR superstructures, termed receptorsomes, both at the cell surface membrane and in the intracellular domain dictate and condition long-term GPCR activities associated with the regulation of protein expression patterns, cellular stress responses and DNA integrity management. The ability of these receptorsomes (often in the absence of typical cell surface ligands) to control complex cellular activities implicates them as key controllers of the functional balance between health and disease. A greater understanding of this function of GPCRs is likely to significantly augment our ability to further employ these proteins in a multitude of diseases. Read full article

provides a valuable window into receptor activity and has become a cornerstone of GPCR screening and pharmacological intracellular signals, making calcium mobilization a highly sensitive functional readout for studying GPCR pharmacology calcium responses within these systems, enabling researchers to investigate multiple aspects of GPCR pharmacology makes calcium assays particularly effective for identifying weak agonists and compounds with modest pharmacological The signal amplification that makes calcium assays highly sensitive can occasionally complicate pharmacological

The pharmacology is unusual. No gene encodes a dedicated amylin receptor. One core receptor, three identities, each with distinct pharmacological properties that must be measured Three subtypes, three pharmacologies This heteromeric architecture is the reason amylin-directed drug Because so many programs now pursue combination, dual, and triple-agonist approaches, profiling amylin pharmacology reports calcitonin instead of amylin, and how the team built a line that finally reads real amylin pharmacology

models that better preserve tissue and disease context, and the translational interpretation of receptor pharmacology Together they illustrate how purinergic pharmacology approaches inflammatory pathology from two directions HEK293 systems are powerful tools for scalable pharmacological screening, but they have a structural cells (iPSCs), iPSC-derived cardiomyocytes, organoid systems, and biosensor-based assays extend GPCR pharmacology Key implications: Signaling outputs depend on biological context, not only receptor pharmacology iPSC

Using a similar pharmacophore  to the one present in the A 2A AR probe CELT-300 , new fluorescent ligands Using a similar pharmacophore  to the one present in the A 2A AR probe CELT-300 , new fluorescent ligands Pharmacological Reviews   2025 , 77  (6), 100092. https://doi.org/10.1016/j.pharmr.2025.100092 . (2) British J Pharmacology 2022, 179 (14), 3496–3511. https://doi.org/10.1111/bph.15103 . (5) Borrmann, T Pharmacol. 2000, 362, 382-391. https://doi.org/10.1007/s002100000315 (7) Jacobson, K. A.

Terry’s Pharmacology Corner is built around that reality. continuous learning environment — supporting scientific reasoning as programs mature, rather than treating pharmacology Why Terry’s Pharmacology Corner Mechanistic understanding evolves. Terry’s Pharmacology Corner provides a structured environment for that evolution: Weekly advanced pharmacology Forty years of pharmacological expertise — organized into a year-round learning framework for serious

risks for safety profiles Proactive detection methodology arms discovery teams with actionable insight Pharmacokinetic Pharmacokinetic approaches are adapted, sometimes employing exotic carriers or solvents to maximize exposure Purpose-driven exposure strategies enhance detection Unique pharmacokinetics may be required for robust design cycles Computational prediction complements biological screening Why Terry’s Corner Terry’s Pharmacology As GPCR science and pharmacological innovation accelerate, timely guidance from foundational to advanced

Orthosteric binding experiments remain a cornerstone of pharmacology, but they demand rigor. Complex Two-Stage Biology Behind Orthosteric Binding GPCR pharmacology rarely follows the neat Langmuir Why Terry’s Corner Weekly pharmacology sessions with Dr. Built for pharmacologists strengthening fundamentals, program teams navigating bottlenecks, and leaders

They unlocked pharmacologically relevant insights that were previously inaccessible.

Despite its therapeutic potential, CB2 pharmacology remains difficult to interrogate with confidence. For researchers working in cannabinoid pharmacology, inflammation, or GPCR-mediated analgesia, these

what they weren’t built for, JB’s group engineered fluorescent ligands based on known GLP-1 and GIP pharmacology They’re team problems — the kind that require chemistry, physiology, pharmacology, structural biology

where receptor trafficking, spatial dynamics, and context-dependent signaling significantly influence pharmacology for Modern Screening Needs Radioligand binding assays have historically been the standard for GPCR pharmacology , preserving receptor conformation, trafficking, and native membrane context—key variables for GPCR pharmacology For teams working in GPCR pharmacology or cannabinoid research, these tools accelerate hit validation

agricultural settings inspired him to train in veterinary medicine, where he was introduced to physiology and pharmacology

Upcoming events:  GPCR-TDD Europe; Pharmacology 2026. Researchers navigating complex datasets, balancing innovation with assay rigor, or working across chemistry–pharmacology–physiology GPCR scientists, translational pharmacologists, biotech discovery teams, and decision-makers who need

What emerged wasn’t just another pharmacology group — it became a collaborative engine for GPCR discovery Turning Silos into Systems The early 2000s were not kind to exploratory pharmacology. But at Monash Institute of Pharmaceutical Sciences, a different idea took root: what if collaboration Why This Matters GPCR research demands integration — pharmacology, structural biology, signaling pathways

Welcome GPCR Fans, Most pharmacologists are trained to chase targets. Upcoming events:  Global GPCR summits and pharmacology forums shaping 2026 priorities. Innovation : Her lab model at Monash is shaping the next generation of GPCR scientists. 👉 Dive into spatial pharmacology GPCR scientists, translational pharmacologists, biotech drug discovery teams, and decision-makers who

the chemical matter  interacting with that target lacks the right properties to produce meaningful pharmacology In this lesson, you’ll gain: A strategic view of how chemical scaffolds shape pharmacologic outcomes It was early structure-based pharmacology. Dr. They are mainstream pharmacology. Advances in formulation and delivery have overcome earlier pharmacokinetic limitations.

GPCRs demanded something different: the integration of modeling, medicinal chemistry, and pharmacology Pharmacologists know they aren’t being oversold. A pharmacologist who understands docking, or a modeler who knows assay constraints, will collaborate

This innovation emerged from years of foundational work in photophysics and GPCR pharmacology.

Allosteric GPCR Binding Sites and Their Ligandability Potential Today, we started the Principles of Pharmacology Emerging Voices in GPCR Biology in Special Issue of Molecular Pharmacology GPCR Events, Meetings, and GPCRs-Targeted Drug Discovery Summit Europe July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology GPCR Jobs Scientist I Cell Biology - Tectonic Therapeutic Senior Scientist, GPCR Pharmacology Research Associate - Professor Graeme Milligan Postdoc in Molecular Pharmacology - The Hauser Group Postdoctoral